Trans-cranial opening of the blood-brain barrier in targeted regions using a stereotaxic brain atlas and focused ultrasound energy

[1]  W. Gedroyc,et al.  The Journal of Therapeutic Ultrasound , 2015, Journal of Therapeutic Ultrasound.

[2]  Chung-Chih Lin,et al.  Design and Experimental Evaluation of a 256-Channel Dual-Frequency Ultrasound Phased-Array System for Transcranial Blood–Brain Barrier Opening and Brain Drug Delivery , 2014, IEEE Transactions on Biomedical Engineering.

[3]  Lothar Lilge,et al.  Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[4]  Fabrice Marquet,et al.  Real-Time, Transcranial Monitoring of Safe Blood-Brain Barrier Opening in Non-Human Primates , 2012, 2012 IEEE International Ultrasonics Symposium.

[5]  M. Livingstone,et al.  Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring , 2012, PloS one.

[6]  Kullervo Hynynen,et al.  Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller. , 2012, Radiology.

[7]  Kullervo Hynynen,et al.  Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies. , 2011, Ultrasound in medicine & biology.

[8]  R. King,et al.  Development and characterization of a tissue-mimicking material for high-intensity focused ultrasound , 2011, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[9]  Kullervo Hynynen,et al.  Two-Photon Fluorescence Microscopy Study of Cerebrovascular Dynamics in Ultrasound-Induced Blood—Brain Barrier Opening , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[10]  K. Hynynen,et al.  Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate. , 2011, Ultrasound in medicine & biology.

[11]  T Deffieux,et al.  Numerical study of a simple transcranial focused ultrasound system applied to blood-brain barrier opening , 2010, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[12]  K. Hynynen,et al.  Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures. , 2010, ACS chemical neuroscience.

[13]  Hao-Li Liu,et al.  Opening of the blood-brain barrier by low-frequency (28-kHz) ultrasound: a novel pinhole-assisted mechanical scanning device. , 2010, Ultrasound in medicine & biology.

[14]  Richard Manasseh,et al.  Cavitation microstreaming and stress fields created by microbubbles. , 2010, Ultrasonics.

[15]  K. Nightingale,et al.  Blood-brain barrier (BBB) disruption using a diagnostic ultrasound scanner and Definity in Mice. , 2009, Ultrasound in medicine & biology.

[16]  Rajiv Chopra,et al.  An MRI-compatible system for focused ultrasound experiments in small animal models. , 2009, Medical physics.

[17]  K. Hynynen,et al.  Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. , 2008, Ultrasound in medicine & biology.

[18]  Hao-Li Liu,et al.  Design and Experimental Evaluations of a Low-Frequency Hemispherical Ultrasound Phased-Array System for Transcranial Blood–Brain Barrier Disruption , 2008, IEEE Transactions on Biomedical Engineering.

[19]  K. Hynynen,et al.  Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models , 2008, PloS one.

[20]  K. Hynynen,et al.  Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. , 2008, Ultrasound in medicine & biology.

[21]  Win-Li Lin,et al.  Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain-barrier disruption. , 2008, Ultrasonics sonochemistry.

[22]  Natalia Vykhodtseva,et al.  Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound , 2007, International journal of cancer.

[23]  Katherine W Ferrara,et al.  Acoustic response of compliable microvessels containing ultrasound contrast agents , 2006, Physics in medicine and biology.

[24]  Natalia Vykhodtseva,et al.  Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. , 2006, Journal of neurosurgery.

[25]  R. Egleton,et al.  Fluorescence imaging of blood–brain barrier disruption , 2006, Journal of Neuroscience Methods.

[26]  K. Hynynen,et al.  Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity , 2006, Physics in medicine and biology.

[27]  Natalia Vykhodtseva,et al.  MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. , 2005, Ultrasound in medicine & biology.

[28]  Ferenc A. Jolesz,et al.  Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications , 2005, NeuroImage.

[29]  K. Hynynen,et al.  MRI investigation of the threshold for thermally induced blood–brain barrier disruption and brain tissue damage in the rabbit brain , 2004, Magnetic resonance in medicine.

[30]  W. Pardridge Blood-brain barrier drug targeting: the future of brain drug development. , 2003, Molecular interventions.

[31]  H. Winn,et al.  High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo. , 2002, Ultrasound in medicine & biology.

[32]  K. Hynynen,et al.  Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. , 2001, Radiology.

[33]  G. Zaharchuk,et al.  Delivery of imaging agents into brain. , 1999, Advanced drug delivery reviews.

[34]  E. Neuwelt,et al.  Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. , 1998, Neurosurgery.

[35]  M. Pollay Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means , 1998 .

[36]  S. Ben‐Sasson,et al.  Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation , 1992, The Journal of cell biology.

[37]  Nicole Fruehauf,et al.  Theory And Practice Of Histotechnology , 2016 .

[38]  K. Hynynen,et al.  MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption. , 2011, Methods in molecular biology.

[39]  Yao-Sheng Tung,et al.  Microbubble-Size Dependence of Focused Ultrasound-Induced Blood–Brain Barrier Opening in Mice In Vivo , 2010, IEEE Transactions on Biomedical Engineering.

[40]  James J. Choi,et al.  Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice. , 2007, Ultrasound in medicine & biology.

[41]  P. Zhong,et al.  Dynamics of bubble oscillation in constrained media and mechanisms of vessel rupture in SWL. , 2001, Ultrasound in medicine & biology.

[42]  A. Woods,et al.  Laboratory histopathology : a complete reference , 1994 .

[43]  D. C. Sheehan,et al.  Theory and Practice of Histotechnology , 1980 .