Preliminary Study on Auxiliary Value of Serum Basic Fetoprotein in Diagnosing Lung Cancer

To characterize basic fetoprotein (BFP) as a new tumor marker, we measured serum levels of BFP and 5 other tumor markers (CA19-9, CEA, NSE, SCC, and TPA) concomitantly in 65 patients with lung cancer, 57 patients with benign pulmonary disease, and 40 healthy volunteers. The sensitivity of BFP was 43%, the specificity 82% and the accuracy 61%. The positivity increased in relation to stage of the disease. There was no correlation between positivity of BFP and histologic type. On the whole, BFP appeared to be analogous to TPA in terms of broad spectrum and to have an auxiliary value in diagnosing lung cancer.

[1]  K. Gohji,et al.  Serum basic fetoprotein in patients with renal cell carcinoma , 1990, Cancer.

[2]  Y. Mizushima,et al.  Clinical significance of the number of positive tumor markers in assisting the diagnosis of lung cancer with multiple tumor marker assay. , 1990, Oncology.

[3]  S. Kamidono,et al.  Clinical evaluation of basic fetoprotein in testicular cancer. , 1987, The Journal of urology.

[4]  Y. Arakawa,et al.  Determination and significance of a new carbohydrate antigen CA19-9 in digestive system cancers. , 1985, Japanese journal of medicine.

[5]  T. Suchi,et al.  Evaluation of serum neuron-specific enolase as a tumor marker for carcinoma of the lung. , 1983, Gan.

[6]  M. Taniguchi,et al.  Production of Monoclonal Anti-Basic Fetoprotein (BFP) and Usefulness of Monoclonal Anti-BFP for Immunodiagnosis of Human Cancer , 1983 .

[7]  J. Minna,et al.  SERUM NEURON-SPECIFIC ENOLASE: A MARKER FOR DISEASE EXTENT AND RESPONSE TO THERAPY OF SMALL-CELL LUNG CANCER , 1982, The Lancet.

[8]  M. Herlyn,et al.  Colorectal carcinoma antigens detected by hybridoma antibodies , 1979, Somatic cell genetics.

[9]  W. Lane,et al.  The value of carcinoembryonic antigen in patients with carcinoma of the lung , 1979, Cancer.

[10]  D. Schmechel,et al.  Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells , 1978, Nature.

[11]  M. Ishii.  A New Carcinoembryonic Protein Characterized by Basic Property , 1978 .

[12]  H. Kato,et al.  Radioimmunoassay for tumor-antigen of human cervical squamous cell carcinoma. , 1977, Cellular and molecular biology, including cyto-enzymology.

[13]  P. Gold,et al.  SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM , 1965, The Journal of experimental medicine.

[14]  V. Björklund,et al.  Antigenicity of Pooled Human Malignant and Normal Tissues by Cyto-Immunological Technique: Presence of an Insoluble, Heat-Labile Tumor Antigen , 1957 .