Gaboxadol, a selective extrasynaptic GABAA agonist, does not generalise to other sleep-enhancing drugs: A rat drug discrimination study

[1]  A. Foster,et al.  Indiplon Is a High-Affinity Positive Allosteric Modulator with Selectivity for α1 Subunit-Containing GABAA Receptors , 2006, Journal of Pharmacology and Experimental Therapeutics.

[2]  Signe í Stórustovu,et al.  Pharmacological Characterization of Agonists at δ-Containing GABAA Receptors: Functional Selectivity for Extrasynaptic Receptors Is Dependent on the Absence of γ2 , 2006, Journal of Pharmacology and Experimental Therapeutics.

[3]  K. Wafford,et al.  Gaboxadol--a new awakening in sleep. , 2006, Current opinion in pharmacology.

[4]  J. Lambert,et al.  Extrasynaptic GABAA Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics , 2005, The Journal of Neuroscience.

[5]  T. Roth,et al.  Efficacy and safety of eszopiclone across 6-weeks of treatment for primary insomnia , 2004, Current medical research and opinion.

[6]  M. Joppa,et al.  In Vivo Pharmacological Characterization of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic , 2004, Journal of Pharmacology and Experimental Therapeutics.

[7]  I. Tobler,et al.  Sleep EEG changes after zolpidem in mice , 2004, Neuroreport.

[8]  C. Sánchez,et al.  Rotarod studies in the rat of the GABAA receptor agonist gaboxadol: lack of ethanol potentiation and benzodiazepine cross-tolerance. , 2003, European journal of pharmacology.

[9]  R. Griffiths,et al.  Principles of drug abuse liability assessment in laboratory animals. , 2003, Drug and alcohol dependence.

[10]  M Danhof,et al.  Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of the Electroencephalogram Effects of GABAA Receptor Modulators: In Vitro-in Vivo Correlations , 2003, Journal of Pharmacology and Experimental Therapeutics.

[11]  B. Frølund,et al.  Characterization of GABAA receptor ligands in the rat cortical wedge preparation: evidence for action at extrasynaptic receptors? , 2002, British journal of pharmacology.

[12]  P. Whiting,et al.  Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors , 2002 .

[13]  C. Hiemke,et al.  Tiagabine, a γ-amino-butyric acid transporter inhibitor impairs spatial learning of rats in the Morris water-maze , 2002, Behavioural Brain Research.

[14]  R. Olsen,et al.  GABAA receptor changes in δ subunit‐deficient mice: Altered expression of α4 and γ2 subunits in the forebrain , 2002 .

[15]  C. Adkins,et al.  α4β3δ GABAAReceptors Characterized by Fluorescence Resonance Energy Transfer-derived Measurements of Membrane Potential* , 2001, The Journal of Biological Chemistry.

[16]  A. Steiger,et al.  Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects. , 2001, American journal of physiology. Endocrinology and metabolism.

[17]  K. Grant,et al.  Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone. , 2001, The Journal of pharmacology and experimental therapeutics.

[18]  J. Carlson,et al.  Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite. , 2001, European journal of pharmacology.

[19]  A. Steiger,et al.  The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects , 2001, Neurobiology of Aging.

[20]  V. Georgiev.  (S)-Zopiclone Sepracor. , 2001, Current opinion in investigational drugs.

[21]  U. Rudolph,et al.  Mechanism of action of the hypnotic zolpidem in vivo , 2000, British journal of pharmacology.

[22]  G. Sperk,et al.  GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain , 2000, Neuroscience.

[23]  I. Martin,et al.  Characterization of the Interaction of Zopiclone with γ-Aminobutyric Acid Type A Receptors , 2000 .

[24]  R. Spealman,et al.  Using behavior to elucidate receptor mechanisms: a review of the discriminative stimulus effects of benzodiazepines. , 2000, Experimental and clinical psychopharmacology.

[25]  R. Mckernan,et al.  Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype , 2000, Nature Neuroscience.

[26]  Masayoshi Tanaka,et al.  Comparison of the effects of zolpidem and zopiclone on nocturnal sleep and sleep latency in the morning: a cross-over study in healthy young volunteers. , 2000, Life sciences.

[27]  Y. Hishikawa,et al.  The effects of benzodiazepine (triazolam), cyclopyrrolone (zopiclone) and imidazopyridine (zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats 1 Presented at the XXth Collegium Internationale Neuro-Psychopharmacologicum Congress, 1996. 1 , 1999, European Neuropsychopharmacology.

[28]  L. Bristow,et al.  Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors , 1998, Neuropharmacology.

[29]  M. Lancel,et al.  Effect of the GABA uptake inhibitor tiagabine on sleep and EEG power spectra in the rat , 1998, British journal of pharmacology.

[30]  Peter Somogyi,et al.  Segregation of Different GABAA Receptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells , 1998, The Journal of Neuroscience.

[31]  H. Jones,et al.  Muscimol-Like Discriminative Stimulus Effects of GABA Agonists in Rats , 1998, Pharmacology Biochemistry and Behavior.

[32]  R. Mckernan,et al.  Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors. , 1997, Molecular pharmacology.

[33]  A. Steiger,et al.  The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans , 1997, Psychopharmacology.

[34]  R. Balster,et al.  The discriminative stimulus effects of muscimol in rats. , 1997, Psychopharmacology.

[35]  M. Lancel,et al.  The GABAA agonist THIP (gaboxadol) increases non‐REM sleep and enhances delta activity in the rat , 1996, Neuroreport.

[36]  M. Lancel,et al.  Role of GABAA Receptors in Sleep Regulation , 1996, Neuropsychopharmacology.

[37]  P. Suzdak,et al.  A Review of the Preclinical Pharmacology of Tiagabine: A Potent and Selective Anticonvulsant GABA Uptake Inhibitor , 1995, Epilepsia.

[38]  P. Suzdak.  Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment , 1994, Epilepsy Research.

[39]  N. Nelson,et al.  Structure, function and brain localization of neurotransmitter transporters. , 1994, The Journal of experimental biology.

[40]  R. Balster,et al.  Discriminative stimulus effects of presynaptic GABA agonists in pentobarbital-trained rats , 1994, Pharmacology Biochemistry and Behavior.

[41]  R. Pruneda,et al.  GABAergic drugs and conflict behavior in the rat: Lack of similarities with the actions of benzodiazepines , 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

[42]  D. Overton,et al.  Historical context of state dependent learning and discriminative drug effects. , 1991, Behavioural pharmacology.

[43]  P. Suzdak,et al.  Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. , 1991, European journal of pharmacology.

[44]  I. Stolerman,et al.  Midazolam cue in rats: effects of drugs acting on GABA and 5-hydroxytryptamine systems, anticonvulsants and sedatives , 1987, Journal of psychopharmacology.

[45]  R. Griffiths,et al.  Discriminative stimulus effects of atypical anxiolytics in baboons and rats. , 1986, The Journal of pharmacology and experimental therapeutics.

[46]  J. B. Appel,et al.  Benzodiazepine receptor mediated discriminative cues: effects of GABA-ergic drugs and inverse agonists. , 1983, Life sciences.

[47]  R. Maurer.  The GABA agonist THIP, a muscimol analogue, does not interfere with the benzodiazepine binding site on rats cortical membranes , 1979, Neuroscience Letters.

[48]  G. Keating,et al.  Zolpidem: a review of its use in the management of insomnia. , 2005, CNS drugs.

[49]  R. Balster,et al.  Pentobarbital-like discriminative stimulus effects of direct GABA agonists in rats , 2005, Psychopharmacology.

[50]  M. Cornfeldt,et al.  GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures , 2005, Psychopharmacology.

[51]  D. Sanger,et al.  The discriminative stimulus properties of zolpidem, a novel imidazopyridine hypnotic , 2004, Psychopharmacology.

[52]  J. Stutzmann,et al.  Pharmacological studies on zopiclone. , 1982, International pharmacopsychiatry.