Research on aging in Portugal

Abstract This review presents an analysis of the current state of gerontological and geriatric research in Portugal, and highlights the need for a national consensus and funding for age-related research projects. Such efforts must be multidisciplinary, since the process of aging encompasses biological, psychological, social, economic and cultural aspects. Demographic studies reveal a growing population of elderly in Portugal as a result of a healthier population in general. This increased life expectancy, however, is accompanied by a parallel increase in degenerative pathologies and care costs among the elderly. Preventive medicine is an important tool to reduce health care costs and avoid or abbreviate suffering from age-related syndromes, but such projects on a national basis neither exists, nor does gerontology or geriatrics receive funding to perform needed research. Consequently, research on aging depends on the initiative of individual investigators who, without funding or cohesive programs, can do little to improve the low scientific output in this area. The implementation of a national program, that can establish health care policy and priorities as well as fund the necessary research, will permit organized cooperation among the different scientific disciplines related to aging. This is a crucial step toward improving present knowledge, ensuring application of experimental and statistical results to the clinical care of the aging population, and attract young investigators to this field.

[1]  I. Santana,et al.  Apolipoprotein E ε4 Allele Is a Risk Factor for Alzheimer’s Disease: The Central Region of Portugal (Coimbra) as a Case Study , 1999, European Neurology.

[2]  J. Cunha-Vaz,et al.  Progression of retinopathy and alteration of the blood-retinal barrier in patients with type 2 diabetes: a 7-year prospective follow-up study , 1998, Graefe's Archive for Clinical and Experimental Ophthalmology.

[3]  P. Agostinho,et al.  Activity of Ionotropic Glutamate Receptors in Retinal Cells: Effect of Ascorbate/Fe2+‐Induced Oxidative Stress , 1996, Journal of neurochemistry.

[4]  A. Rego,et al.  Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress. , 1999, Free radical biology & medicine.

[5]  J. Cunha-Vaz,et al.  Mapping retinal fluorescein leakage with confocal scanning laser fluorometry of the human vitreous. , 1999, Archives of ophthalmology.

[6]  J. Ramalho,et al.  A technical approach to the evaluation of glucose oxidation: implications for diabetic cataract. , 1996, Ophthalmic research.

[7]  P. Greengard,et al.  Regulated cleavage of alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail , 1993, Neuroscience.

[8]  C. Oliveira,et al.  Involvement of Oxidative Stress on the Impairment of Energy Metabolism Induced by Aβ Peptides on PC12 Cells: Protection by Antioxidants , 1999, Neurobiology of Disease.

[9]  R. Cunha,et al.  Cross Talk Between A1 and A2A Adenosine Receptors in the Hippocampus and Cortex of Young Adult and Old Rats , 1999 .

[10]  R. Cunha,et al.  Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats , 2000, Neurochemistry International.

[11]  J. P. Andrade,et al.  Effects of age and sex on the water maze performance and hippocampal cholinergic fibers in rats , 1999, Neuroscience Letters.

[12]  P. Santana Ageing in Portugal: regional iniquities in health and health care. , 2000, Social science & medicine.

[13]  C. Oliveira,et al.  Mitochondrial function impairment induced by amyloid β‐peptide on PC12 cells , 1998 .

[14]  M. Lechner,et al.  Apolipoprotein E genotype of a Portuguese control population and Alzheimer's disease patients , 1997 .

[15]  S. De Henauw,et al.  Longitudinal changes in the intake of energy and macronutrients of elderly Europeans. SENECA Investigators. , 1996, European journal of clinical nutrition.

[16]  A. Rego,et al.  Adenosine Triphosphate Degradation Products After Oxidative Stress and Metabolic Dysfunction in Cultured Retinal Cells , 1997, Journal of neurochemistry.

[17]  A. de Mendonça,et al.  Adenosine and neuronal plasticity. , 1996, Life sciences.

[18]  P. Agostinho,et al.  Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: effect of antioxidants , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  C. P. de Groot,et al.  Consumption of unfiltered coffee brews in elderly Europeans. SENECA Investigators. , 1996, European journal of clinical nutrition.

[20]  N. Sousa,et al.  Effects of corticosterone treatment and rehabilitation on the hippocampal formation of neonatal and adult rats. An unbiased stereological study , 1998, Brain Research.

[21]  C. P. de Groot,et al.  Longitudinal changes in anthropometric characteristics of elderly Europeans. , 1996 .

[22]  C. Oliveira,et al.  Effects of apolipoprotein E genotype on blood lipid composition and membrane platelet fluidity in Alzheimer's disease. , 1999, Biochimica et biophysica acta.

[23]  J. Cunha-Vaz Diabetic Retinopathy: Surrogate Outcomes for Drug Development for Diabetic Retinopathy , 2000, Ophthalmologica.

[24]  P. Moreira,et al.  Effect of zinc ions on the cytotoxicity induced by the amyloid beta-peptide. , 2000, Antioxidants & redox signaling.

[25]  H. Girão,et al.  Cholesterol may act as an antioxidant in lens membranes. , 1999, Current eye research.

[26]  R. Cunha,et al.  Increase in the Number, G Protein Coupling, and Efficiency of Facilitatory Adenosine A2A Receptors in the Limbic Cortex, but not Striatum, of Aged Rats , 1999, Journal of neurochemistry.

[27]  E. Leite,et al.  Prevalence and surgical complications of pseudoexfoliation syndrome in Portuguese patients with senile cataract , 1996, Journal of cataract and refractive surgery.

[28]  E. Rocha,et al.  Age-related changes in the volume of somata and organelles of cerebellar granule cells , 1998, Neurobiology of Aging.

[29]  Maria Amália Botelho Autonomia funcional em idosos : caracterização multidimensional em idosos utentes de um centro de saúde urbano , 1999 .

[30]  C. Oliveira,et al.  Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress. , 1997, Free radical biology & medicine.

[31]  J. Cunha-Vaz Optical sensors for clinical ocular fluorometry , 1997, Progress in Retinal and Eye Research.

[32]  Paul Greengard,et al.  Inhibition of Protein Phosphatase 1 Stimulates Secretion of Alzheimer Amyloid Precursor Protein , 1995, Molecular medicine.

[33]  J. Ferro,et al.  Aphasia type, age and cerebral infarct localisation , 1997, Journal of Neurology.

[34]  J. Ramalho,et al.  An experimental model for the evaluation of lipid peroxidation in lens membranes. , 1996, Current eye research.

[35]  P. Moreira,et al.  Susceptibility to β-Amyloid-Induced Toxicity Is Decreased in Goto-Kakizaki Diabetic Rats: Involvement of Oxidative Stress , 2000, Experimental Neurology.

[36]  Z. Bashir,et al.  Endogenous Adenosine Attenuates Long-term Depression and Depotentiation in the CA1 Region of the Rat Hippocampus , 1997, Neuropharmacology.

[37]  M. Rocha,et al.  Does pulmonary tuberculosis change with ageing? , 1997, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[38]  J. P. Andrade,et al.  Arcuate nucleus of the hypothalamus: Effects of age and sex , 1998, The Journal of comparative neurology.

[39]  A. Rendas,et al.  Avaliação multidimensional de idosos : estudo piloto no ambulatório , 1997 .

[40]  F. Holsboer,et al.  Maintenance of hippocampal cell numbers in young and aged rats submitted to chronic unpredictable stress. Comparison with the effects of corticosterone treatment. , 1998, Stress.

[41]  J. Ramalho,et al.  Cholesterol oxides accumulate in human cataracts. , 1998, Experimental eye research.