Effect of Reducing Renal Arterial Blood Pressure by Balloon Catheter on Urate Excretion in the Dog.∗

Summary Reduction of mean renal arterial blood pressure of Dalmatian and mongrel dogs by inflating a balloon-tipped catheter inserted into the aorta just above the renal arteries resulted in a proportionate decrease in GFR, less decrease in CPAH, a precipitous fall in UNaV/FNa, no appreciable change in UKV/FK. In the Dalmatian, under conditions of net secretion of urate, UurateV/Furate was unchanged or rose somewhat. A comparable response of UurateV/Furate was obtained in mongrels under conditions of net reabsorption of urate, a result consistent with tubular secretion of urate masked by preponderant tubular reabsorption.