Simulation model for overloaded monoclonal antibody variants separations in ion-exchange chromatography.
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Massimo Morbidelli | Marco Lattuada | Pascal Valax | Guido Ströhlein | M. Morbidelli | G. Ströhlein | M. Lattuada | P. Valax | Bertrand Guélat | Lydia Delegrange | Bertrand Guélat | L. Delegrange
[1] D. Davies,et al. The three-dimensional structure at 6 A resolution of a human gamma Gl immunoglobulin molecule. , 1971, The Journal of biological chemistry.
[2] Y. Sun,et al. Thermodynamic model for nonlinear electrostatic adsorption equilibrium of protein , 2006 .
[3] C. Horváth,et al. Theory for electrostatic interaction chromatography of proteins. , 1991, Analytical chemistry.
[4] B. Kabakoff,et al. Identification of multiple sources of charge heterogeneity in a recombinant antibody. , 2001, Journal of chromatography. B, Biomedical sciences and applications.
[5] Anita M. Katti,et al. Fundamentals of Preparative and Nonlinear Chromatography , 1994 .
[6] Steven M Cramer,et al. Investigation of protein binding affinity and preferred orientations in ion exchange systems using a homologous protein library , 2009, Biotechnology and bioengineering.
[7] N Avdalovic,et al. Protein variant separations by cation-exchange chromatography on tentacle-type polymeric stationary phases. , 1998, Journal of chromatography. A.
[8] D. Anderson,et al. Gradient chromatofocusing high-performance liquid chromatography. I. Practical aspects. , 1997, Journal of chromatography. A.
[9] L. Sluyterman,et al. Chromatofocusing: Isoelectric focusing on ion-exchange columns : I. General Principles , 1978 .
[10] Tony Cano,et al. Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography. , 2011, Journal of chromatography. A.
[11] L. Sluyterman,et al. Chromatofocusing: Isoelectric focusing on ion-exchange columns : II. Experimental verification☆ , 1978 .
[12] A. Rozhkova. Quantitative analysis of monoclonal antibodies by cation-exchange chromatofocusing. , 2009, Journal of chromatography. A.
[13] M. Morbidelli,et al. Increasing the activity of monoclonal antibody therapeutics by continuous chromatography (MCSGP) , 2010, Biotechnology and bioengineering.
[14] D R Burton,et al. Crystallohydrodynamics for solving the hydration problem for multi-domain proteins: open physiological conformations for human IgG. , 2001, Biophysical chemistry.
[15] M. Morbidelli,et al. Model simulation and experimental verification of a cation-exchange IgG capture step in batch and continuous chromatography. , 2011, Journal of chromatography. A.
[16] D. Frey,et al. Experimental and numerical studies of the chromatofocusing of dilute proteins using retained pH gradients formed on a strong-base anion-exchange column. , 1997, Journal of chromatography. A.
[17] Massimo Morbidelli,et al. Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP) , 2008, Biotechnology and Bioengineering.
[18] L. Sluyterman,et al. Chromatofocusing : III. The properties of a deae-agarose anion exchanger and its suitability for protein separations , 1981 .
[19] Hongcheng Liu,et al. Heterogeneity of monoclonal antibodies. , 2008, Journal of pharmaceutical sciences.
[20] L. Sluyterman,et al. Chromatofocusing. IV. Properties of an agarose poly(ethyleneimine) ion exchanger and its suitability for protein separations , 1981 .
[21] Abraham M. Lenhoff,et al. Electrostatic and van der Waals contributions to protein adsorption: computation of equilibrium constants , 1993 .
[22] Giorgio Carta,et al. pH transitions in cation exchange chromatographic columns containing weak acid groups. , 2007, Journal of chromatography. A.
[23] Massimo Morbidelli,et al. Preparative weak cation-exchange chromatography of monoclonal antibody variants I. Single-component adsorption. , 2008, Journal of chromatography. A.
[24] Massimo Morbidelli,et al. A continuous, counter-current multi-column chromatographic process incorporating modifier gradients for ternary separations. , 2006, Journal of chromatography. A.
[25] C. Roth,et al. Electrostatic and van der Waals Contributions to Protein Adsorption: Comparison of Theory and Experiment , 1995 .
[26] D. Farnan,et al. Multiproduct high-resolution monoclonal antibody charge variant separations by pH gradient ion-exchange chromatography. , 2009, Analytical chemistry.
[27] C. Roth,et al. Van der Waals interactions involving proteins. , 1996, Biophysical journal.
[28] A. Lenhoff,et al. Protein Adsorption Isotherms through Colloidal Energetics , 1999 .
[29] Massimo Morbidelli,et al. Electrostatic model for protein adsorption in ion-exchange chromatography and application to monoclonal antibodies, lysozyme and chymotrypsinogen A. , 2010, Journal of chromatography. A.
[30] R. Ionescu,et al. Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods. , 2008, Current pharmaceutical biotechnology.
[31] M. Morbidelli,et al. Adsorption of monoclonal antibody variants on analytical cation-exchange resin. , 2007, Journal of chromatography. A.
[32] M. Morbidelli,et al. Chromatographic behavior of a polyclonal antibody mixture on a strong cation exchanger column. Part I: Adsorption characterization. , 2008, Journal of chromatography. A.
[33] V. Adrian Parsegian,et al. Van Der Waals Forces: A Handbook for Biologists, Chemists, Engineers, and Physicists , 2005 .
[34] P. C. Hiemenz,et al. Principles of colloid and surface chemistry , 1977 .