Vertical optokinetic nystagmus and saccades in normal human subjects.

PURPOSE Optokinetic stimulation induces nystagmus that can be used to test the saccadic and visual-tracking systems in some patients with voluntary gaze palsies. The purpose of this study was to characterize vertical optokinetic nystagmus (OKN) in normal human subjects, comparing the dynamic properties of the quick phases with voluntary saccades of similar size and measuring the slow-phase responses to visual stimuli with a range of spatial and temporal frequencies. METHODS Vertical OKN and saccades were recorded in 10 healthy adult subjects (age range, 24-54 years) using the magnetic search coil technique. The optokinetic (OK) stimulus subtended 72 degrees horizontally and 60 degrees vertically, consisted of black-and-white stripes with a spatial frequency of 0.04, 0.08, or 0.16 cyc/deg, and moved vertically at 10 to 50 deg/s. Vertical and horizontal saccades to visual targets separated by 1 degrees to 10 degrees were also elicited. RESULTS Over 95% of quick phases were less than 10 degrees in amplitude; voluntary saccades of this amplitude range were slightly faster than quick phases of similar size. The amplitude-peak velocity relationships and amplitude-duration relationships of upward and downward fast movements (saccades or quick phases) were similar. Most vertical slow-phase OK responses showed greater gain for upward stimulus motion. OK gain decreased with increasing stimulus speed and increased spatial frequency, so that there was a general decrease in slow-phase velocity gain with increasing temporal frequency. CONCLUSIONS In this study, the best OK responses were obtained using stripes with lower spatial frequencies and lower stripe speeds (0.4 cyc/deg at 10 deg/s). The dynamic properties of vertical quick phases of nystagmus are similar enough to those of voluntary saccades for OK stimulation to be used as a clinical test of the vertical saccadic system in individuals with voluntary gaze palsy.

[1]  I Kato,et al.  Vertical optokinetic nystagmus in normal individuals. , 1996, Acta oto-laryngologica. Supplementum.

[2]  Nick Fogt,et al.  The Neurology of Eye Movements, 3rd ed. , 2000 .

[3]  Stimulus velocity dependence of human vertical optokinetic nystagmus and afternystagmus. , 1992, Journal of vestibular research : equilibrium & orientation.

[4]  M. Igarashi,et al.  Asymmetry of vertical optokinetic after-nystagmus in squirrel monkeys. , 1988, Acta oto-laryngologica.

[5]  D A Robinson.  The purpose of eye movements. , 1978, Investigative ophthalmology & visual science.

[6]  A. Fuchs,et al.  Saccadic, smooth pursuit, and optokinetic eye movements of the trained cat. , 1978, The Journal of physiology.

[7]  K. Hepp,et al.  Deficits in torsional and vertical rapid eye movements and shift of Listing's plane after uni- and bilateral lesions of the rostral interstitial nucleus of the medial longitudinal fasciculus , 2004, Experimental Brain Research.

[8]  R. Leigh,et al.  Conjugate ocular oscillations during shifts of the direction and depth of visual fixation. , 1999, Investigative ophthalmology & visual science.

[9]  R. Leigh,et al.  Pathophysiology of slow vertical saccades in progressive supranuclear palsy , 2001, Neurology.

[10]  J. Gibson.  The Senses Considered As Perceptual Systems , 1967 .

[11]  W. Skrandies.  The Upper and Lower Visual Field of Man: Electrophysiological and Functional Differences , 1987 .

[12]  R. Baloh,et al.  Vertical optokinetic nystagmus and optokinetic afternystagmus in humans. , 1990, Journal of vestibular research : equilibrium & orientation.

[13]  H. Collewijn,et al.  Binocular co‐ordination of human vertical saccadic eye movements. , 1988, The Journal of physiology.

[14]  J. K. O'Regan,et al.  Eye movements : from physiology to cognition : selected/edited proceedings of the Third European Conference on Eye Movements, Dourdan, France, September 1985 , 1987 .

[15]  R. Yee,et al.  Velocities of vertical saccades with different eye movement recording methods. , 1985, Investigative ophthalmology & visual science.

[16]  A. Bronstein,et al.  Reduced duration of a visual motion aftereffect in congenital nystagmus , 1998, Documenta Ophthalmologica.

[17]  S Sakurai,et al.  Horizontal and vertical optokinetic nystagmus in man. , 1978, ORL; journal for oto-rhino-laryngology and its related specialties.

[18]  R. Jell,et al.  Human vertical optokinetic nystagmus and after-response, and their dependence upon head orientation with respect to gravity. , 1994, Journal of vestibular research : equilibrium & orientation.

[19]  Han Collewijn,et al.  Directional asymmetries of human optokinetic nystagmus , 2004, Experimental Brain Research.

[20]  William F. Hughes,et al.  Functional Basis of Ocular Motility Disorders , 1984 .

[21]  H. Kornhuber,et al.  Natural and drug-induced variations of velocity and duration of human saccadic eye movements: Evidence for a control of the neural pulse generator by local feedback , 2004, Biological Cybernetics.

[22]  L F Dell'Osso,et al.  Saccades in extremes of lateral gaze. , 1979, Investigative ophthalmology & visual science.

[23]  J. Büttner-Ennever,et al.  Premotor neurons for vertical eye movements in the rostral mesencephalon of monkey and human: Histologic identification by parvalbumin immunostaining , 1998, The Journal of comparative neurology.

[24]  M. Correia,et al.  Effects of position change on optokinetic nystagmus and optokinetic after-nystagmus in man , 1983, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[25]  Vertical optokinetic nystagmus , 1962, Neurology.

[26]  M. Correia,et al.  Vertical optokinetic nystagmus and after-responses during backward tilt. , 1997, Aviation, space, and environmental medicine.

[27]  H. Collewijn,et al.  Binocular co‐ordination of human horizontal saccadic eye movements. , 1988, The Journal of physiology.

[28]  R. Leigh,et al.  A hypothetical scheme for the brainstem control of vertical gaze , 2000, Neurology.

[29]  Manning J. Correia,et al.  Further Observations on the Effects of Head Position on Vertical OKN and OKAN in Normal Subjects , 1987, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[30]  C. Prablanc,et al.  Kinematics of centrifugal and centripetal saccadic eye movements in man , 1988, Vision Research.

[31]  L. Hainline,et al.  Orientational asymmetries in small-field optokinetic nystagmus in human infants , 1984, Behavioural Brain Research.

[32]  N. Shimizu.  [Neurology of eye movements]. , 2000, Rinsho shinkeigaku = Clinical neurology.

[33]  B. Cohen,et al.  Vertical optokinetic nystagmus and vestibular nystagmus in the monkey: Up-down asymmetry and effects of gravity , 2004, Experimental Brain Research.

[34]  C. Darlot,et al.  Asymmetries of vertical vestibular nystagmus in the cat , 2004, Experimental Brain Research.

[35]  M. Jeannerod,et al.  Maturation of the optokinetic response: genetic and environmental factors. , 1974, Brain research.

[36]  R. Yee,et al.  Analysis of electro-oculographic artifact during vertical saccadic eye movements , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[37]  K. Hepp,et al.  On the generation of vertical and torsional rapid eye movements in the monkey , 2004, Experimental Brain Research.

[38]  W. E. Collins,et al.  Some characteristics of optokinetic eye-movement patterns: a comparative study. , 1970, Aerospace medicine.

[39]  The influence of preexiting oscillations on the binoculars optokinetic response , 1985 .

[40]  The influence of preexisting oscillations on the binocular optokinetic response. , 1985, Annals of neurology.

[41]  W. Becker,et al.  Human oblique saccades: Quantitative analysis of the relation between horizontal and vertical components , 1990, Vision Research.

[42]  I. P. Howard,et al.  Up-down asymmetry in human vertical optokinetic nystagmus and afternystagmus: contributions of the central and peripheral retinae , 2004, Experimental Brain Research.

[43]  B. Cohen,et al.  Vertical glaze paralysis and the rostral interstitial nucleus of the medial longitudinal fasciculus. , 1982, Brain : a journal of neurology.

[44]  J. L. Homick,et al.  Effect of macular ablation on vertical optokinetic nystagmus in the squirrel monkey. , 1978, ORL; journal for oto-rhino-laryngology and its related specialties.

[45]  B. Neville,et al.  A neurovisceral storage disease with vertical supranuclear ophthalmoplegia, and its relationship to Niemann-Pick disease. A report of nine patients. , 1973, Brain : a journal of neurology.

[46]  J. Sharpe,et al.  Vertical saccades in senescence. , 1993, Investigative ophthalmology & visual science.

[47]  C. Kennard,et al.  Predictive eye saccades are different from visually triggered saccades , 1987, Vision Research.

[48]  B. Cohen,et al.  Quantitative analysis of the velocity characteristics of optokinetic nystagmus and optokinetic after‐nystagmus , 1977, The Journal of physiology.

[49]  R. Leigh,et al.  Dynamic properties of horizontal and vertical eye movements in parkinsonian syndromes , 1996, Annals of neurology.

[50]  M Igarashi,et al.  Comparison of vertical and horizontal optokinetic nystagmus in the squirrel monkey. , 1977, ORL; journal for oto-rhino-laryngology and its related specialties.

[51]  D. Frost,et al.  Different programming modes of human saccadic eye movements as a function of stimulus eccentricity: Indications of a functional subdivision of the visual field , 1976, Biological Cybernetics.

[52]  R. John Leigh,et al.  Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease , 1997, Vision Research.

[53]  Effect of vestibulo-cerebellar lesions on asymmetry of vertical optokinetic functions in the squirrel monkey. , 1990, Acta oto-laryngologica.

[54]  R D Yee,et al.  The dynamics of vertical eye movements in normal human subjects. , 1983, Aviation, space, and environmental medicine.

[55]  R. Surtees,et al.  Vertical saccade palsy: a presenting sign of Niemann‐Pick type IIS , 1994, European journal of neurology.

[56]  A. Berthoz,et al.  Modifications of gain asymmetry and beating field of vertical optokinetic nystagmus in microgravity , 1986, Neuroscience Letters.

[57]  W. Thomson,et al.  AN ASYMMETRY IN THE OPTOKINETIC NYSTAGMUS RESPONSE IN NORMAL INDIVIDUALS , 1984, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[58]  D. Levi,et al.  Disturbances of small-field horizontal and vertical optokinetic nystagmus in amblyopia. , 1980, Investigative ophthalmology & visual science.