Ontogenetic differences in sensitivity to LiCl- and amphetamine-induced taste avoidance in preweanling rats.

When amphetamine is associated with a tastant conditioned stimulus, rats learn to avoid the taste even when employing doses that promote conditioned place preference. One hypothesis raised to account for this effect proposes that taste avoidance induced by amphetamine may be motivated by fear. A sensitive period has been identified in the rat (until postnatal day 10) in which infants learn conditioned appetitive effects to stimuli to which aversions are conditioned after this period. Exogenous administration of corticosterone within this period reverses this effect, generating aversive conditioning. In the present study, we tested conditioning of aversions to amphetamine or LiCl, within and after the sensitive period (Experiments 1 and 2). A third experiment evaluated unconditioned rejection of an aversive quinine solution within the sensitive period. Finally, we tested whether corticosterone administration before conditioning modulates amphetamine-induced taste avoidance. After the sensitive period, infant rats rejected the solution paired with amphetamine or LiCl after 2 conditioning trials, but within the sensitive period, aversions were conditioned only by LiCl and after 4 conditioning trials. Amphetamine-induced taste avoidance was not observed even when corticosterone was administered before conditioning. Additionally, during the sensitive period, a low LiCl dose promoted conditioned taste preference. According to Experiment 3, parameters employed in this study were suitable to yield rejection of aversive solutions within the sensitive period. These results suggest that during the sensitive period, there is a notable resistance to the acquisition of taste avoidance induced by amphetamine. The present experimental framework may represent a useful tool for studying mechanisms underlying taste avoidance and aversion effects.

[1]  N. Spear,et al.  A comparison between taste avoidance and conditioned disgust reactions induced by ethanol and lithium chloride in preweanling rats. , 2010, Developmental psychobiology.

[2]  R. Sullivan,et al.  Defining age limits of the sensitive period for attachment learning in rat pups. , 2010, Developmental psychobiology.

[3]  N. Spear,et al.  Differential role of mu, delta and kappa opioid receptors in ethanol-mediated locomotor activation and ethanol intake in preweanling rats , 2010, Physiology & Behavior.

[4]  S. Reilly,et al.  Basolateral amygdala and morphine-induced taste avoidance in the rat , 2010, Physiology & Behavior.

[5]  M. Chotro,et al.  The effect of taste familiarity on intake and taste reactivity in infant rats. , 2009, Developmental psychobiology.

[6]  N. Spear,et al.  Binge ethanol exposure in late gestation induces ethanol aversion in the dam but enhances ethanol intake in the offspring and affects their postnatal learning about ethanol. , 2009, Alcohol.

[7]  N. Spear,et al.  Ethanol-mediated aversive learning as a function of locomotor activity in a novel environment in infant Sprague-Dawley rats , 2009, Pharmacology Biochemistry and Behavior.

[8]  S. Hsiao,et al.  Re-examination of amphetamine-induced conditioned suppression of tastant intake in rats: the task-dependent drug effects hypothesis. , 2008, Behavioral neuroscience.

[9]  A. Riley,et al.  Noradrenergic antagonism enhances the conditioned aversive effects of cocaine , 2008, Pharmacology Biochemistry and Behavior.

[10]  G. Laviola,et al.  Increased ethanol intake after prenatal ethanol exposure: Studies with animals , 2007, Neuroscience & Biobehavioral Reviews.

[11]  C. Arias,et al.  Ontogenetic difference in ethanol reinforcing properties: the role of the opioid system , 2007, Behavioural pharmacology.

[12]  N. Spear,et al.  Ethanol acceptance is high during early infancy and becomes still higher after previous ethanol ingestion. , 2007, Alcoholism, clinical and experimental research.

[13]  L. Parker,et al.  Effect of prior exposure to a lithium- and an amphetamine-paired flavor on the acoustic startle response in rats. , 2007, Journal of experimental psychology. Animal behavior processes.

[14]  S. Reilly,et al.  C-fos expression in the rat brain following lithium chloride-induced illness , 2007, Brain Research.

[15]  C. Arias,et al.  Interactions between prenatal ethanol exposure and postnatal learning about ethanol in rat pups. , 2006, Alcohol.

[16]  S. Moriceau,et al.  Maternal presence serves as a switch between learning fear and attraction in infancy , 2006, Nature Neuroscience.

[17]  S. Moriceau,et al.  Dual Circuitry for Odor–Shock Conditioning during Infancy: Corticosterone Switches between Fear and Attraction via Amygdala , 2006, The Journal of Neuroscience.

[18]  M. Chotro,et al.  Ethanol-induced preferences or aversions as a function of age in preweanling rats. , 2006, Behavioral neuroscience.

[19]  L. Parker.  The role of nausea in taste avoidance learning in rats and shrews , 2006, Autonomic Neuroscience.

[20]  M. Chotro,et al.  Increased palatability of ethanol after prenatal ethanol exposure is mediated by the opioid system , 2005, Pharmacology Biochemistry and Behavior.

[21]  N. Spear,et al.  Fetal or infantile exposure to ethanol promotes ethanol ingestion in adolescence and adulthood: a theoretical review. , 2005, Alcoholism, clinical and experimental research.

[22]  C. Reichel,et al.  The partial D2-like dopamine receptor agonist terguride acts as a functional antagonist in states of high and low dopaminergic tone: evidence from preweanling rats , 2005, Psychopharmacology.

[23]  S. Moriceau,et al.  Corticosterone controls the developmental emergence of fear and amygdala function to predator odors in infant rat pups , 2004, International Journal of Developmental Neuroscience.

[24]  S. Moriceau,et al.  Corticosterone influences on Mammalian neonatal sensitive-period learning. , 2004, Behavioral neuroscience.

[25]  C. M. Krall,et al.  Effects of a partial dopamine D2-like agonist on the cocaine-induced behavioral sensitization of preweanling rats , 2003, Pharmacology Biochemistry and Behavior.

[26]  L. Parker.  Taste avoidance and taste aversion: Evidence for two different processes , 2003, Learning & behavior.

[27]  G. Alonso,et al.  Stimulus preexposure reduces generalization of conditioned taste aversions between alcohol and non-alcohol flavors in infant rats. , 2003, Behavioral neuroscience.

[28]  S. Levine.  Primary social relationships influence the development of the hypothalamic–pituitary–adrenal axis in the rat , 2001, Physiology & Behavior.

[29]  C. Limebeer,et al.  The antiemetic drug ondansetron intereferes with lithium-induced conditioned rejection reactions, but not lithium induced taste avoidance in rats. , 2000 .

[30]  R. Sullivan,et al.  Neurophysiology: Good memories of bad events in infancy , 2000, Nature.

[31]  P. S. Grigson,et al.  Morphine-induced suppression of saccharin intake is correlated with elevated corticosterone levels , 2000, Brain Research.

[32]  K. Berridge.  Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns , 2000, Neuroscience & Biobehavioral Reviews.

[33]  P. S. Grigson.  Conditioned taste aversions and drugs of abuse: a reinterpretation. , 1997, Behavioral neuroscience.

[34]  L. Takahashi.  Glucocorticoids and the hippocampus , 1996, Molecular Neurobiology.

[35]  M. Roitman,et al.  c-Fos induction in rat brainstem in response to ethanol- and lithium chloride-induced conditioned taste aversions. , 1996, Alcoholism, clinical and experimental research.

[36]  M. Monda,et al.  EEG arousal, sympathetic activity, and brown adipose tissue thermogenesis after conditioned taste aversion , 1996, Physiology & Behavior.

[37]  Division on Earth.  Guide for the Care and Use of Laboratory Animals , 1996 .

[38]  L. Parker.  Rewarding drugs produce taste avoidance, but not taste aversion , 1995, Neuroscience & Biobehavioral Reviews.

[39]  T. Wolfle.  Institute of Laboratory Animal Resources. , 1995 .

[40]  B. Pearce,et al.  Principles and pitfalls in the analysis of prenatal treatment effects in multiparous species. , 1992, Neurotoxicology and teratology.

[41]  N. Spear,et al.  Ethanol-mediated taste aversions and state-dependency in preweanling (16-day-old) rats. , 1990, Behavioral and neural biology.

[42]  N. Spear,et al.  Ontogenetic differences in the association of gustatory and tactile cues with lithium chloride and footshock. , 1990, Behavioral and neural biology.

[43]  C. Kuhn,et al.  Anterior and posterior, but not cheek, intraoral cannulation procedures elevate serum corticosterone levels in neonatal rat pups. , 1989, Developmental psychobiology.

[44]  N. Spear,et al.  Ontogenetic differences in conditioning of an aversion to a gustatory CS with a peripheral US. , 1988, Behavioral and neural biology.

[45]  N. Spear,et al.  Further examination of ontogenetic limitations on conditioned taste aversion. , 1987, Developmental psychobiology.

[46]  Z. Amit,et al.  Conditioned taste aversion induced by self-administered drugs: Paradox revisited , 1987, Neuroscience & Biobehavioral Reviews.

[47]  R. Sapolsky,et al.  Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period , 1986, Brain Research Reviews.

[48]  N. Spear,et al.  Conditioning of an odor aversion in preweanlings with isolation from home nest as the unconditioned stimulus. , 1985, Developmental psychobiology.

[49]  John Garcia,et al.  A General Theory of Aversion Learning a , 1985, Annals of the New York Academy of Sciences.

[50]  E. Blass,et al.  Activation and odor conditioning of suckling behavior in 3-day-old albino rats. , 1982, Journal of experimental psychology. Animal behavior processes.

[51]  W. P. Smotherman,et al.  In utero taste/odor aversion conditioning in the rat , 1982, Physiology & Behavior.

[52]  B. Campbell,et al.  Ontogeny of amphetamine anorexia in rats: a behavioral analysis. , 1981, Journal of comparative and physiological psychology.

[53]  H. Cappell,et al.  Effects of amygdala lesions on taste aversions produced by amphetamine and LiCl , 1976, Pharmacology Biochemistry and Behavior.

[54]  V. G. Kassil',et al.  Conditioned reflex responses of the sympathetico-adrenal system to an aversive taste stimulus , 2006, Neuroscience and Behavioral Physiology.

[55]  R. Sullivan,et al.  Examining the role of endogenous opioids in learned odor-stroke associations in infant rats. , 2006, Developmental psychobiology.

[56]  N. White,et al.  Anatomical disassociation of amphetamine's rewarding and aversive effects: An intracranial microinjection study , 2004, Psychopharmacology.

[57]  C. Limebeer,et al.  The antiemetic drug ondansetron interferes with lithium-induced conditioned rejection reactions, but not lithium-induced taste avoidance in rats. , 2000, Journal of experimental psychology. Animal behavior processes.

[58]  S. A. McDougall,et al.  Ontogeny of dopamine agonist-induced sensitization: role of NMDA receptors , 1997, Psychopharmacology.

[59]  L. Takahashi.  Glucocorticoids and the hippocampus. Developmental interactions facilitating the expression of behavioral inhibition. , 1996, Molecular neurobiology.

[60]  P. Kehoe.  Opioids, Behavior, and Learning in Mammalian Development , 1988 .

[61]  G. Hale,et al.  National Research Council , 1923, Journal of the American Institute of Electrical Engineers.