Hemodynamic Effects of Muscle Relaxants a Comparative Study between Pancuronium and Vecuronium

Physiology of neuromuscular transmission: The transmission of impulses from nerve to muscle is mediated by Acetylcholine ,released by depolarization of nerve terminal. Acetylcholine ABSTRACT: BACKGROUND: The cardiac effects of equipotent doses of pancuronium and vecuronium were compared in 90 patients, anaesthetized with thiopentone and maintenance with halothane. Heart rate and arterial pressure were recorded from simultaneous tracings of ECG and pulse oximeter and automatic noninvasive monitor respectively. Pancuronium (0000 mg/kg) caused a significant increase in heart rate and significant changes in arterial pressure.The equipotent dose of vecuronium (0009 mg/kg) caused no significant changes in heart rate and arterial pressure. OBJECTIVE: The study was designed to determine the comparison between Pancuronium Bromide &Vecuronium Bromide according to cardiovascular effects in young adult patients undergo different variety of surgical operation under general anaesthesia. METHODS : Fifty adult patients (ASA class I and II ) were allocated to 2 subgroups: Group A (n=29) received pancuronium bromide 0000mg/Kg Group B (n=29)received vecuronium bromide 0009mg/Kg Anaesthesia was induced with Fentanyl (%μg/Kg), Sodium thiopentone (4-6mg/Kg) and maintained with Halothane %1 in Oxygen.The neuromuscular blocking agents were given and after 2-3 minutes tracheal intubation was performed with ease in all patients. Heart rate and mean arterial pressure were recorded every%0minutes in all patients for40 minutes. RESULT: There was significant differences in mean heart rate and mean arterial blood pressure in group A (p<0009). There was no significant differences in mean heart rate and mean blood pressure in group B (p<0009). CONCLUSION: From this study, it can be concluded that: %The use of pancuronium as a muscle relaxant cause significant increase in heart rate and mean blood pressure in anaesthetized patients. 2The use of vecuronium as a muscle relaxant cause insignificant changes in heart rate and mean blood pressure in anaesthetized patients that lead us to prefer vecuronium on pancuronium for hemodynamic stability. KEYWORD: pancuronium,vecuronium,fentanyl,thiopentone,halothane.

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