COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia
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S. Brack | R. Hepler | R. Walter | J. Bertschinger | D. Saro | G. S. Laszlo | R. Santimaria | Vanessa Baeriswyl | A. Zumsteg | C. Gudgeon | K. Klupsch | C. Albani | Roland Scholz | W. Lembke | S. Wendelspiess | Ulrike von der Bey | Isabella Attinger-toller | J. Dannenberg | David Senn | Elena Kage | Susann König-Friedrich | Fanny Dupuy | Lucijana Dinkel | Robert Hepler | Roger Santimaria
[1] R. Walter. Investigational CD33-targeted therapeutics for acute myeloid leukemia , 2018, Expert opinion on investigational drugs.
[2] N. Gökbuget,et al. Clinical applications and safety evaluation of the new CD19 specific T-cell engager antibody construct blinatumomab , 2017, Expert opinion on drug safety.
[3] R. Gale,et al. Gemtuzumab ozogamicin in acute myeloid leukemia , 2017, Leukemia.
[4] A. Wolf,et al. Blinatumomab, a Bispecific T-cell Engager (BiTE®) for CD-19 Targeted Cancer Immunotherapy: Clinical Pharmacology and Its Implications , 2016, Clinical Pharmacokinetics.
[5] J. Guenot,et al. Characterization of CD33/CD3 Tetravalent Bispecific Tandem Diabodies (TandAbs) for the Treatment of Acute Myeloid Leukemia , 2016, Clinical Cancer Research.
[6] C. Klein,et al. A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors , 2016, Clinical Cancer Research.
[7] S. Brack,et al. A Bispecific HER2-Targeting FynomAb with Superior Antitumor Activity and Novel Mode of Action , 2014, Molecular Cancer Therapeutics.
[8] A. Henn,et al. Preclinical Characterization of AMG 330, a CD3/CD33-Bispecific T-Cell–Engaging Antibody with Potential for Treatment of Acute Myelogenous Leukemia , 2014, Molecular Cancer Therapeutics.
[9] W. Hiddemann,et al. CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330. , 2014, Blood.
[10] G. Ehninger,et al. Costimulation improves the killing capability of T cells redirected to tumor cells expressing low levels of CD33: description of a novel modular targeting system , 2014, Leukemia.
[11] A. Mackensen,et al. T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct , 2013, Leukemia.
[12] S. Raimondi,et al. Clinical Significance of CD33 Nonsynonymous Single-Nucleotide Polymorphisms in Pediatric Patients with Acute Myeloid Leukemia Treated with Gemtuzumab-Ozogamicin–Containing Chemotherapy , 2013, Clinical Cancer Research.
[13] W. Hiddemann,et al. MYELOID NEOPLASIA CD 33 target validation and sustained depletion of AML blasts in long-term cultures by the bispeci fi c T-cell – engaging antibody AMG 330 , 2013 .
[14] D. Banner,et al. Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain , 2012, mAbs.
[15] D. Neri,et al. A Novel, Non-immunogenic Fyn SH3-derived Binding Protein with Tumor Vascular Targeting Properties* , 2007, Journal of Biological Chemistry.
[16] H. Oettgen,et al. The T3/T cell receptor complex: antigenic distinction between the two 20‐kd T3 (T3‐delta and T3‐epsilon) subunits. , 1985, The EMBO journal.