Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

[1]  Marco Prinz,et al.  The role of peripheral immune cells in the CNS in steady state and disease , 2017, Nature Neuroscience.

[2]  R. Ransohoff.  A polarizing question: do M1 and M2 microglia exist? , 2016, Nature Neuroscience.

[3]  S. Linnarsson,et al.  Origin, fate and dynamics of macrophages at central nervous system interfaces , 2016, Nature Immunology.

[4]  G. Nolan,et al.  Automated Mapping of Phenotype Space with Single-Cell Data , 2016, Nature Methods.

[5]  A. Nimmerjahn,et al.  TAM receptors regulate multiple features of microglial physiology , 2016, Nature.

[6]  M. Prinz,et al.  Do not judge a cell by its cover—diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation , 2015, Seminars in Immunopathology.

[7]  Sean C. Bendall,et al.  An interactive reference framework for modeling a dynamic immune system , 2015, Science.

[8]  Burkhard Becher,et al.  Immune attack: the role of inflammation in Alzheimer disease , 2015, Nature Reviews Neuroscience.

[9]  Eli R. Zunder,et al.  Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm , 2015, Nature Protocols.

[10]  M. Graeber.  Neuroinflammation: No Rose by Any Other Name , 2014, Brain pathology.

[11]  A. McAllister,et al.  Alterations in Immune Cells and Mediators in the Brain: It's Not Always Neuroinflammation! , 2014, Brain pathology.

[12]  H. Weiner,et al.  Differential roles of microglia and monocytes in the inflamed central nervous system , 2014, The Journal of experimental medicine.

[13]  S. Beggs,et al.  Sublime Microglia: Expanding Roles for the Guardians of the CNS , 2014, Cell.

[14]  T. Owens,et al.  Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response , 2014, Journal of Neuroinflammation.

[15]  L. Steinman.  Immunology of relapse and remission in multiple sclerosis. , 2014, Annual review of immunology.

[16]  F. Gage,et al.  Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors , 2014, Nature Neuroscience.

[17]  S. Gygi,et al.  Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia , 2013, Nature Neuroscience.

[18]  R. Milner,et al.  Extensive vascular remodeling in the spinal cord of pre-symptomatic experimental autoimmune encephalomyelitis mice; increased vessel expression of fibronectin and the α5β1 integrin , 2013, Experimental Neurology.

[19]  C. Power,et al.  The regulation of reactive changes around multiple sclerosis lesions by phosphorylated signal transducer and activator of transcription. , 2013, Journal of neuropathology and experimental neurology.

[20]  T. Luedde,et al.  A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation , 2013, Nature Neuroscience.

[21]  S. Appel,et al.  Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis , 2013, Journal of Neuroimmune Pharmacology.

[22]  Sean C. Bendall,et al.  Normalization of mass cytometry data with bead standards , 2013, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[23]  L. Tran,et al.  Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease , 2013, Cell.

[24]  F. Schmitt,et al.  Neuroinflammatory phenotype in early Alzheimer's disease , 2013, Neurobiology of Aging.

[25]  A. Aguzzi,et al.  Microglia: Scapegoat, Saboteur, or Something Else? , 2013, Science.

[26]  L. Steinman.  The discovery of natalizumab, a potent therapeutic for multiple sclerosis , 2012, The Journal of cell biology.

[27]  Erin F. Simonds,et al.  A platinum‐based covalent viability reagent for single‐cell mass cytometry , 2012, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[28]  Sean C. Bendall,et al.  Extracting a Cellular Hierarchy from High-dimensional Cytometry Data with SPADE , 2011, Nature Biotechnology.

[29]  F. Rossi,et al.  Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool , 2011, Nature Neuroscience.

[30]  F. Ginhoux,et al.  [Microglia arise from extra-embryonic yolk sac primitive progenitors]. , 2011, Medecine sciences : M/S.

[31]  Erin F. Simonds,et al.  Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum , 2011, Science.

[32]  A. Cardona,et al.  Isolation of brain and spinal cord mononuclear cells using percoll gradients. , 2011, Journal of visualized experiments : JoVE.

[33]  B. Hemmer,et al.  Repetitive Pertussis Toxin Promotes Development of Regulatory T Cells and Prevents Central Nervous System Autoimmune Disease , 2010, PloS one.

[34]  A. Mildner,et al.  CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. , 2009, Brain : a journal of neurology.

[35]  Ryan Insolera,et al.  Interleukin‐10 provides direct trophic support to neurons , 2009, Journal of neurochemistry.

[36]  T. Möller,et al.  Distinct neuroinflammatory profile in post-mortem human Huntington's disease , 2009, Neuroreport.

[37]  F. Rossi,et al.  Local self-renewal can sustain CNS microglia maintenance and function throughout adult life , 2007, Nature Neuroscience.

[38]  A. Mildner,et al.  Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions , 2007, Nature Neuroscience.

[39]  C. Moon,et al.  Increased phosphorylation of cyclic AMP response element-binding protein in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis , 2007, Brain Research.

[40]  Mario Roederer,et al.  Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major , 2007, Nature Medicine.

[41]  Lawrence Steinman,et al.  A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage , 2007, Nature Medicine.

[42]  R. Ransohoff,et al.  Isolation of murine microglial cells for RNA analysis or flow cytometry , 2006, Nature Protocols.

[43]  F. Rossi,et al.  Origin and distribution of bone marrow‐derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis , 2006, Glia.

[44]  J. Ortaldo,et al.  Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells , 2006, European journal of immunology.

[45]  D. Pleasure,et al.  Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice. , 2005, Brain : a journal of neurology.

[46]  J. Whitton,et al.  Cutting Edge: Re-evaluating the In Vivo Cytokine Responses of CD8+ T Cells during Primary and Secondary Viral Infections1 , 2005, The Journal of Immunology.

[47]  K. Hoyt,et al.  CRE-Mediated Transcription Is Increased in Huntington's Disease Transgenic Mice , 2004, The Journal of Neuroscience.

[48]  S. Khoury,et al.  Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis , 2003, The Journal of experimental medicine.

[49]  Yue Sun,et al.  Pertussis Toxin Enhances Th1 Responses by Stimulation of Dendritic Cells 1 , 2003, The Journal of Immunology.

[50]  T. Forsthuber,et al.  Pertussis Toxin Modulates the Immune Response to Neuroantigens Injected in Incomplete Freund’s Adjuvant: Induction of Th1 Cells and Experimental Autoimmune Encephalomyelitis in the Presence of High Frequencies of Th2 Cells1 , 2002, The Journal of Immunology.

[51]  S. Barnum,et al.  Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis , 2002, European journal of immunology.

[52]  Sawsan Youssef,et al.  Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine , 2002, Nature Medicine.

[53]  Lawrence Steinman,et al.  Multiple sclerosis: a two-stage disease , 2001, Nature Immunology.

[54]  P. Sassone-Corsi,et al.  Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[55]  S. W. Davies,et al.  Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.

[56]  Douglas Walker,et al.  Inflammation and Alzheimer's disease pathogenesis , 1996, Neurobiology of Aging.

[57]  D. C. Carter,et al.  Atomic structure and chemistry of human serum albumin , 1993, Nature.

[58]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[59]  D. Schmitt,et al.  In vitro adhesion of human epidermal Langerhans cells to laminin and fibronectin occurs through β1 integrin receptors , 1992, Journal of leukocyte biology.

[60]  F. Sánchez‐Madrid,et al.  Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin , 1992, Nature.

[61]  R. Sobel,et al.  Fibronectin in multiple sclerosis lesions. , 1989, The American journal of pathology.

[62]  P. Mcgeer,et al.  Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains , 1988, Neurology.

[63]  D. Linthicum,et al.  Acute experimental autoimmune encephalomyelitis in mice. I. Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system. , 1982, Cellular immunology.