Cross-border malaria: a major obstacle for malaria elimination.

Movement of malaria across international borders poses a major obstacle to achieving malaria elimination in the 34 countries that have committed to this goal. In border areas, malaria prevalence is often higher than in other areas due to lower access to health services, treatment-seeking behaviour of marginalized populations that typically inhabit border areas, difficulties in deploying prevention programmes to hard-to-reach communities, often in difficult terrain, and constant movement of people across porous national boundaries. Malaria elimination in border areas will be challenging and key to addressing the challenges is strengthening of surveillance activities for rapid identification of any importation or reintroduction of malaria. This could involve taking advantage of technological advances, such as spatial decision support systems, which can be deployed to assist programme managers to carry out preventive and reactive measures, and mobile phone technology, which can be used to capture the movement of people in the border areas and likely sources of malaria importation. Additionally, joint collaboration in the prevention and control of cross-border malaria by neighbouring countries, and reinforcement of early diagnosis and prompt treatment are ways forward in addressing the problem of cross-border malaria.

[1]  Rifat Atun,et al.  Effect of Investment in Malaria Control on Child Mortality in Sub-Saharan Africa in 2002–2008 , 2011, PloS one.

[2]  Robert Steffen,et al.  Migrants as a major risk group for imported malaria in European countries. , 2006, Journal of travel medicine.

[3]  N. Ganguly,et al.  Tackling the malaria problem in the South-East Asia Region: Need for a change in policy? , 2013, The Indian journal of medical research.

[4]  Petrina Uusiku,et al.  The receptive versus current risks of Plasmodium falciparum transmission in Northern Namibia: implications for elimination , 2013, BMC Infectious Diseases.

[5]  Robert H Gilman,et al.  The effect of deforestation on the human-biting rate of Anopheles darlingi, the primary vector of Falciparum malaria in the Peruvian Amazon. , 2006, The American journal of tropical medicine and hygiene.

[6]  R. Weber,et al.  Imported Infectious Disease and Purpose of Travel, Switzerland , 2007, Emerging infectious diseases.

[7]  A. Kaneko,et al.  Changing patterns of forest malaria among the mobile adult male population in Chumkiri District, Cambodia. , 2008, Acta tropica.

[8]  Hui Liu,et al.  The challenges of malaria elimination in Yunnan Province, People's Republic of China. , 2012, The Southeast Asian journal of tropical medicine and public health.

[9]  M. Schultz Malaria in migrants and travellers. , 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[10]  C. Roseman MIGRATION AS A SPATIAL AND TEMPORAL PROCESS , 1971 .

[11]  M. Gandhi,et al.  Targeting imported malaria through social networks: a potential strategy for malaria elimination in Swaziland , 2013, Malaria Journal.

[12]  F. Nosten,et al.  Malaria Burden and Artemisinin Resistance in the Mobile and Migrant Population on the Thai–Myanmar Border, 1999–2011: An Observational Study , 2013, PLoS medicine.

[13]  O. Sabot,et al.  A new global malaria eradication strategy , 2008, The Lancet.

[14]  F. Castelli,et al.  Knowledge, attitudes, and practices on malaria preventive measures of migrants attending a public health clinic in northern Italy. , 2006, Journal of travel medicine.

[15]  J. Lines,et al.  Community‐randomized trial of lambdacyhalothrin‐treated hammock nets for malaria control in Yanomami communities in the Amazon region of Venezuela , 2007, Tropical medicine & international health : TM & IH.

[16]  K. Thimasarn,et al.  Factors influencing malaria endemicity in Yunnan Province, PR China (analysis of spatial pattern by GIS). Geographical Information System. , 1998, The Southeast Asian journal of tropical medicine and public health.

[17]  R. Steffen,et al.  Imported malaria (1985-95): trends and perspectives. , 1999, Bulletin of the World Health Organization.

[18]  K. Leder,et al.  Malaria in travelers: a review of the GeoSentinel surveillance network. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[19]  W. Stauffer,et al.  The visiting friends or relatives traveler in the 21st century: time for a new definition. , 2010, Journal of travel medicine.

[20]  David L. Smith,et al.  Preventing the Reintroduction of Malaria in Mauritius: A Programmatic and Financial Assessment , 2011, PloS one.

[21]  Keivan Shalileh,et al.  Family physicians' satisfaction in Iran: a long path ahead , 2010, The Lancet.

[22]  P. Gayral,et al.  Purification and properties of phosphoenolpyruvate carboxylase from Molinema dessetae (Nematoda: Filarioidea) , 1993, Parasitology.

[23]  N. Speybroeck,et al.  Epidemiology of forest malaria in central Vietnam: a large scale cross-sectional survey , 2005, Malaria Journal.

[24]  G. Glass,et al.  Linking deforestation to malaria in the Amazon: characterization of the breeding habitat of the principal malaria vector, Anopheles darlingi. , 2009, The American journal of tropical medicine and hygiene.

[25]  Caroline O Buckee,et al.  Human movement data for malaria control and elimination strategic planning , 2012, Malaria Journal.

[26]  R. Snow,et al.  Space-time variation of malaria incidence in Yunnan province, China , 2009, Malaria Journal.

[27]  L. Ranford-Cartwright,et al.  Characteristics of Plasmodium falciparum parasites that survive the lengthy dry season in eastern Sudan where malaria transmission is markedly seasonal. , 1998, The American journal of tropical medicine and hygiene.

[28]  B. Trayner,et al.  Public–private partnerships in trust-based public health social networking: Connecting organizations for regional disease surveillance (CORDS) , 2011 .

[29]  B. Greenwood Control to elimination: implications for malaria research. , 2008, Trends in parasitology.

[30]  S. Hay,et al.  A global assessment of closed forests, deforestation and malaria risk. , 2006, Annals of tropical medicine and parasitology.

[31]  Marcel Tanner,et al.  Effect of irrigation and large dams on the burden of malaria on a global and regional scale. , 2005, The American journal of tropical medicine and hygiene.

[32]  L. Weiss,et al.  Imported malaria in the Bronx: review of 51 cases recorded from 1986 to 1991. , 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[33]  S. Kitvatanachai,et al.  A survey on malaria in mobile Cambodians in Aranyaprathet, Sa Kaeo Province, Thailand. , 2003, The Southeast Asian journal of tropical medicine and public health.

[34]  K. Ungchusak,et al.  Mekong Basin Disease Surveillance (MBDS): A Trust-Based Network , 2013, Emerging health threats journal.

[35]  K. Behbehani,et al.  Imported malaria in Kuwait. , 1985, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[36]  Parasites and vectors carry no passport: how to fund cross-border and regional efforts to achieve malaria elimination , 2012, Malaria Journal.

[37]  A. Bhumiratana,et al.  Surveillance of imported bancroftian filariasis after two-year multiple-dose diethylcarbamazine treatment. , 2005, The Southeast Asian journal of tropical medicine and public health.

[38]  S. Lindsay,et al.  Reducing malaria by mosquito-proofing houses. , 2002, Trends in parasitology.

[39]  Andrew J Tatem,et al.  International population movements and regional Plasmodium falciparum malaria elimination strategies , 2010, Proceedings of the National Academy of Sciences.

[40]  K. Thimasarn,et al.  Malaria trends and challenges in the Greater Mekong Subregion. , 2009, The Southeast Asian journal of tropical medicine and public health.

[41]  T. Q. Binh,et al.  Control of malaria: a successful experience from Viet Nam. , 2002, Bulletin of the World Health Organization.

[42]  Mary E. Wilson,et al.  Fever in returned travelers: results from the GeoSentinel Surveillance Network. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[43]  W. Chaveepojnkamjorn,et al.  Malaria infection among the migrant population along the Thai-Myanmar border area. , 2004, The Southeast Asian journal of tropical medicine and public health.

[44]  D. Molyneux,et al.  Deforestation: effects on vector-borne disease , 1993, Parasitology.

[45]  Organização Mundial de Saúde,et al.  World malaria report 2011 , 2011 .

[46]  Kimberly C. Brouwer,et al.  Socio-demographics and the development of malaria elimination strategies in the low transmission setting. , 2012, Acta tropica.

[47]  Gerard C Kelly,et al.  Further shrinking the malaria map: how can geospatial science help to achieve malaria elimination? , 2013, The Lancet. Infectious diseases.

[48]  M. Rowland,et al.  Malaria epidemiology and control in refugee camps and complex emergencies. , 2001, Annals of tropical medicine and parasitology.

[49]  Qi Gao,et al.  Malaria in overseas labourers returning to China: an analysis of imported malaria in Jiangsu Province, 2001–2011 , 2014, Malaria Journal.

[50]  R. Prothero Malaria in Latin America: Environmental and human factors , 1995 .

[51]  Doaa M Sultan,et al.  Imported malaria in United Arab Emirates: evaluation of a new DNA extraction technique using nested PCR. , 2009, The Korean journal of parasitology.

[52]  Saorin Kim,et al.  Focused Screening and Treatment (FSAT): A PCR-Based Strategy to Detect Malaria Parasite Carriers and Contain Drug Resistant P. falciparum, Pailin, Cambodia , 2012, PloS one.

[53]  W. Chaveepojnkamjorn,et al.  Behavioral factors and malaria infection among the migrant population, Chiang Rai province. , 2005, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[54]  C. Mendis,et al.  Clustering of malaria infections within an endemic population: risk of malaria associated with the type of housing construction. , 1991, The American journal of tropical medicine and hygiene.

[55]  N. Singh,et al.  Anopheline ecology and malaria transmission at a new irrigation project area (Bargi Dam) in Jabalpur (Central India). , 2000, Journal of the American Mosquito Control Association.

[56]  N. Gratz,et al.  Emerging and resurging vector-borne diseases. , 1999, Annual review of entomology.

[57]  A Stern,et al.  International population movements and public health in the Mekong region: an overview of some issues concerning mapping. , 1998, The Southeast Asian journal of tropical medicine and public health.

[58]  Prothero Rm,et al.  Disease and Mobility: A Neglected Factor in Epidemiology , 1977 .

[59]  Guisseppi A. Forgionne,et al.  Decision Making Support Systems: Achievements and Challenges for the New Decade , 2002 .

[60]  J. Iqbal,et al.  Imported malaria in Kuwait (1985-2000). , 2006, Journal of travel medicine.

[61]  R. Bayoumi,et al.  Status of imported malaria in a control zone of the United Arab Emirates bordering an area of unstable malaria. , 1993, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[62]  A. Bhumiratana,et al.  Imported bancroftian filariasis: diethylcarbamazine response and benzimidazole susceptibility of Wuchereria bancrofti in dynamic cross-border migrant population targeted by the National Program to Eliminate Lymphatic Filariasis in South Thailand. , 2010, Acta tropica.

[63]  W. Chaveepojnkamjorn,et al.  Malaria infection and life-style factors among hilltribes along the Thai-Myanmar border area, northern Thailand. , 2004, The Southeast Asian journal of tropical medicine and public health.

[64]  J. Wolpert BEHAVIORAL ASPECTS OF THE DECISION TO MIGRATE , 1965 .

[65]  M. Tanner,et al.  Modern geographical reconnaissance of target populations in malaria elimination zones , 2010, Malaria Journal.

[66]  A. C. Marques,et al.  Human migration and the spread of malaria in Brazil. , 1987, Parasitology today.

[67]  J. Breman,et al.  The challenge of malaria eradication in the twenty-first century: research linked to operations is the key. , 2011, Vaccine.

[68]  J. Xu,et al.  Border malaria in Yunnan, China. , 1997, The Southeast Asian journal of tropical medicine and public health.

[69]  R. Maharaj,et al.  The feasibility of malaria elimination in South Africa , 2012, Malaria Journal.

[70]  R. Packard Agricultural development, migrant labor and the resurgence of malaria in Swaziland. , 1986, Social science & medicine.

[71]  A. Dash,et al.  Malaria parasite burden and treatment seeking behavior in ethnic communities of Assam, Northeastern India. , 2006, The Journal of infection.

[72]  J. Le bras,et al.  Predictive factors of malaria in travelers to areas where malaria is endemic. , 2002, Archives of internal medicine.

[73]  Surveillance. A Research Agenda for Malaria Eradication: Monitoring, Evaluation, and Surveillance , 2011, PLoS medicine.

[74]  Rajendra Maharaj,et al.  Seven years of regional malaria control collaboration--Mozambique, South Africa, and Swaziland. , 2007, The American journal of tropical medicine and hygiene.

[75]  Ian Riley,et al.  Baseline spatial distribution of malaria prior to an elimination programme in Vanuatu , 2010, Malaria Journal.

[76]  A. Sleigh,et al.  Resettlement for China's Three Gorges Dam: socio-economic impact and institutional tensions , 2000 .

[77]  T. Adak,et al.  Therapeutic efficacy of antimalarial drugs along the eastern Indo-Nepal border: a cross-border collaborative study. , 2005, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[78]  L. Gresham,et al.  Trust across borders: responding to 2009 H1N1 influenza in the Middle East. , 2009, Biosecurity and bioterrorism : biodefense strategy, practice, and science.

[79]  J. Kaewkungwal,et al.  Spatio-temporal patterns of malaria infection in Bhutan: a country embarking on malaria elimination , 2011, Malaria Journal.

[80]  W. Takken,et al.  Novel strategies lead to pre-elimination of malaria in previously high-risk areas in Suriname, South America , 2012, Malaria Journal.

[81]  R. Horton,et al.  Malaria elimination: worthy, challenging, and just possible , 2010, The Lancet.

[82]  Nancy Fullman,et al.  Global malaria mortality between 1980 and 2010: a systematic analysis , 2012, The Lancet.

[83]  Uriel Kitron,et al.  The Role of Human Movement in the Transmission of Vector-Borne Pathogens , 2009, PLoS neglected tropical diseases.

[84]  R. Snow,et al.  Call to action: priorities for malaria elimination , 2010, The Lancet.

[85]  Kami Kim,et al.  Characterization of two putative potassium channels in Plasmodium falciparum , 2008, Malaria Journal.

[86]  P. Chiodini,et al.  Migrant health and infectious diseases in the UK: findings from the last 10 years of surveillance. , 2014, Journal of public health.

[87]  S. Pattanasin,et al.  Predictors of malaria-association with rubber plantations in Thailand , 2012, BMC Public Health.

[88]  K. Thimasarn,et al.  Malaria control in Bhutan: case study of a country embarking on elimination , 2012, Malaria Journal.

[89]  K. Moji,et al.  Joint malaria surveys lead towards improved cross-border cooperation between Savannakhet province, Laos and Quang Tri province, Vietnam , 2012, Malaria Journal.

[90]  T. Q. Tuy,et al.  KAP surveys and malaria control in Vietnam: findings and cautions about community research. , 2005, The Southeast Asian journal of tropical medicine and public health.

[91]  N. Low,et al.  Imported Malaria in Children in Industrialized Countries, 1992–2002 , 2009, Emerging Infectious Diseases.

[92]  Jaranit Kaewkungwal,et al.  Development of temporal modelling for forecasting and prediction of malaria infections using time-series and ARIMAX analyses: A case study in endemic districts of Bhutan , 2010, Malaria Journal.

[93]  B. Carme Substantial increase of malaria in inland areas of eastern French Guiana , 2005, Tropical medicine & international health : TM & IH.

[94]  I. Alkhalife Imported malaria infections diagnosed at the Malaria Referral Laboratory in Riyadh, Saudi Arabia. , 2003, Saudi medical journal.

[95]  Qiang Fang,et al.  Malaria in the Greater Mekong Subregion: heterogeneity and complexity. , 2012, Acta tropica.

[96]  P. Wijeyaratne,et al.  Status of insecticide resistance of malaria kala-azar and Japanese encephalitis vectors in Bangladesh Bhutan India and Nepal (BBIN). , 2004 .

[97]  Abdullah S Ali,et al.  The use of mobile phone data for the estimation of the travel patterns and imported Plasmodium falciparum rates among Zanzibar residents , 2009, Malaria Journal.

[98]  W. Wernsdorfer,et al.  From malaria control to eradication: The WHO perspective , 2009, Tropical medicine & international health : TM & IH.

[99]  Albert-László Barabási,et al.  Understanding individual human mobility patterns , 2008, Nature.

[100]  D. Boulware,et al.  Travel medicine considerations for North American immigrants visiting friends and relatives. , 2004, JAMA.

[101]  R. Snow,et al.  Shrinking the malaria map: progress and prospects , 2010, Lancet.

[102]  Pham Van Ky,et al.  Long-Lasting Insecticidal Hammocks for Controlling Forest Malaria: A Community-Based Trial in a Rural Area of Central Vietnam , 2009, PloS one.

[103]  P. Spiegel,et al.  Discourse on malaria elimination: where do forcibly displaced persons fit in these discussions? , 2013, Malaria Journal.

[104]  R. Prothero Malaria, Forests and People in Southeast Asia , 1999 .

[105]  L. Mullany,et al.  Mortality rates in conflict zones in Karen, Karenni, and Mon states in eastern Burma , 2006, Tropical medicine & international health : TM & IH.

[106]  Shafiei Fatemeh,et al.  Epidemiology of Malaria in Khorasan Razavi Province North-eastern of Iran within last 7 years (April 2001- March 2008) , 2008 .

[107]  P. Martens,et al.  Malaria on the move: human population movement and malaria transmission. , 2000, Emerging infectious diseases.

[108]  Flemming Konradsen,et al.  Strong association between house characteristics and malaria vectors in Sri Lanka. , 2003, The American journal of tropical medicine and hygiene.

[109]  J. Keystone,et al.  Health risks associated with visiting friends and relatives in developing countries , 2005, Current infectious disease reports.

[110]  H. Basseri,et al.  Malaria prevention among afghan refugees in a malarious area, southeastern Iran , 2010, Bulletin de la Societe de pathologie exotique.

[111]  T. Q. Tuy,et al.  Forest malaria in Vietnam: a challenge for control. , 2004, The American journal of tropical medicine and hygiene.

[112]  Marcel Tanner,et al.  A spatial decision support system for guiding focal indoor residual spraying interventions in a malaria elimination zone , 2011 .

[113]  V. Kansakar Nepal-India Open Border: Prospects, Problem and Challenges , 2012 .

[114]  Shannon Doocy,et al.  The burden of malaria in post-emergency refugee sites: A retrospective study , 2011, Conflict and health.

[115]  Marcel Tanner,et al.  A high-resolution geospatial surveillance-response system for malaria elimination in Solomon Islands and Vanuatu , 2013, Malaria Journal.

[116]  Wenyi Zhang,et al.  Spatial analysis of malaria in Anhui province, China , 2008, Malaria Journal.

[117]  B. Nagpal,et al.  Identification of malaria hot spots for focused intervention in tribal state of India: a GIS based approach , 2009, International journal of health geographics.

[118]  Caroline W. Kabaria,et al.  Establishing the extent of malaria transmission and challenges facing pre-elimination in the Republic of Djibouti , 2011, BMC infectious diseases.

[119]  J. Kaewkungwal,et al.  Respondent-driven sampling on the Thailand-Cambodia border. I. Can malaria cases be contained in mobile migrant workers? , 2011, Malaria Journal.

[120]  Jonathan A. Patz,et al.  Deforestation and Malaria in Mâncio Lima County, Brazil , 2010, Emerging infectious diseases.

[121]  L. Mullany,et al.  Cross‐border malaria control for internally displaced persons: observational results from a pilot programme in eastern Burma/Myanmar , 2009, Tropical medicine & international health : TM & IH.

[122]  T. Q. Tuy,et al.  Accuracy of the health information system on malaria surveillance in Vietnam. , 2007, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[123]  W. Almirón,et al.  Malaria transmission in two localities in north-western Argentina , 2009, Malaria Journal.

[124]  M. Gatton,et al.  Prevalence of asymptomatic malaria and bed net ownership and use in Bhutan, 2013: a country earmarked for malaria elimination , 2014, Malaria Journal.

[125]  M. Alpers,et al.  Cross-species interactions between malaria parasites in humans. , 2000, Science.

[126]  R. López-Vélez,et al.  Malaria Journal BioMed Central Research Open Access Epidemiology and clinical features of vivax malaria imported to Europe: Sentinel surveillance data from TropNetEurop , 2022 .

[127]  M. Rowland,et al.  Insecticide‐treated plastic tarpaulins for control of malaria vectors in refugee camps , 2002, Medical and veterinary entomology.

[128]  W. Satimai,et al.  Characteristics and malaria prevalence of migrant populations in malaria-endemic areas along the Thai-Cambodian border. , 2012, The Southeast Asian journal of tropical medicine and public health.

[129]  J. Patz,et al.  Effects of environmental change on emerging parasitic diseases. , 2000, International journal for parasitology.

[130]  S. Hay,et al.  Social and environmental determinants of malaria in space and time in Viet Nam. , 2011, International journal for parasitology.

[131]  K. Behbehani,et al.  Aspects of imported malaria at a district general hospital in non-endemic Kuwait, Arabian Gulf , 1988, European Journal of Epidemiology.