Metabolism of isoflurane in patients receiving isoniazid.

Administration of isoniazid in human patients may increase the metabolism of enflurane and increase serum fluoride ion concentrations (1) to levels that may transiently impair renal function (2,3). Although isoniazid therapy increases isoflurane metabolism in animals (4,5), its effects on the metabolism of this agent in human patients are unknown. We determined the breakdown of isoflurane in two patients treated with isoniazid by measuring the concentrations of fluoride ion and trifluoroacetic acid (TFA) in their serum, as well as fluoride ion, TFA, and organic fluoride levels in their urine before, during, and after administration of isoflurane.

[1]  E. Eger,et al.  I‐653 Resists Degradation in Rats , 1988, Anesthesia and analgesia.

[2]  J. Schenkman,et al.  Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes. , 1987, The Journal of biological chemistry.

[3]  M. Halsey,et al.  Serum fluoride levels in morbidly obese patients: enflurane compared with isoflurane anaesthesia , 1987, Anaesthesia.

[4]  E. Eger,et al.  The Extent of Metabolism of Inhaled Anesthetics in Humans , 1986, Anesthesiology.

[5]  R. Mazze,et al.  Renal effects of enflurane and halothane in patients with abnormal renal function. , 1984, Anesthesiology.

[6]  L. Sbordone,et al.  Metabolism by Rat Hepatic Microsomes of Fluorinated Ether Anesthetics Following Isoniazid Administration , 1980, Anesthesiology.

[7]  A. J. Gandolfi,et al.  Detection of Fluorinated Anesthetic Metabolites by Sodium Fusion , 1980, Anesthesia and analgesia.

[8]  S. Rice,et al.  Effects of isoniazid treatment on selected hepatic mixed-function oxidases. , 1979, Drug metabolism and disposition: the biological fate of chemicals.

[9]  N. T. Smith,et al.  Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers. , 1977, Anesthesiology.

[10]  S. Acchiardo,et al.  Fluoride kinetics after enflurane anesthesia in healthy and anephric patients and in patients with poor renal function , 1976 .

[11]  G. Barr,et al.  Renal Effects and Metabolism of Isoflurane in Man , 1974, Anesthesiology.

[12]  B. Hitt,et al.  Metabolism of Isoflurane in Fischer 344 Rats and Man , 1974, Anesthesiology.

[13]  E. Eger,et al.  Comparative toxicity of isoflurane, halothane, fluroxene and diethyl ether in human volunteers , 1973, Canadian Anaesthetists' Society journal.

[14]  D. Taves,et al.  Serum fluoride analysis with the fluoride electrode. , 1970, The Journal of laboratory and clinical medicine.

[15]  A. Conney,et al.  Effect of streptozotocin-induced diabetes in the rat on the metabolism of fluorinated volatile anesthetics. , 1987, Anesthesiology.

[16]  R. Mazze.  Metabolism of the inhaled anaesthetics: implications of enzyme induction. , 1984, British journal of anaesthesia.