An Improved Method for Testing of Bacteriostatic Agents Using Virulent Human Type Tubercle Bacilli.∗

Summary A new technic for rapidly and efficiently testing the growth-inhibiting action of substances on virulent human type tubercle bacilli is described. The order of effectiveness of four compounds in inhibiting the growth of the avirulent acid-fast rapidly growing organism 607 was found to be: Sulfathiazole, sulfadiazine, 4,4'diaminodiphenylsulfone, and sulfanilamide, while for the virulent human strain of tubercle bacillus H37Rv the order was found to be: 4,4'diaminodiphenylsulfone, sulfathiazole, sulfadiazine, and sulfanilamide.