Upconversion Nanoparticles as a Contrast Agent for Photoacoustic Imaging in Live Mice

An inclusion complex of NaYF4 :Yb(3+) ,Er(3+) upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4 :Yb(3+) ,Er(3+) is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

[1]  Zhuang Liu,et al.  Carbon nanotubes as photoacoustic molecular imaging agents in living mice. , 2008, Nature nanotechnology.

[2]  Jing Yong Ye,et al.  Photoacoustic emission from fluorescent nanodiamonds enhanced with gold nanoparticles , 2012, Biomedical optics express.

[3]  Wei Chen,et al.  Nanoparticle luminescence thermometry , 2002 .

[4]  Xinmai Yang,et al.  Photoacoustic tomography of a rat cerebral cortex in vivo with au nanocages as an optical contrast agent. , 2007, Nano letters.

[5]  C. S. Lim,et al.  Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping , 2010, Nature.

[6]  Vladimir P Zharov,et al.  Quantum dots as multimodal photoacoustic and photothermal contrast agents. , 2008, Nano letters.

[7]  Sanjiv S Gambhir,et al.  Family of enhanced photoacoustic imaging agents for high-sensitivity and multiplexing studies in living mice. , 2012, ACS nano.

[8]  Lorenz Fischer,et al.  Aufkonvertierende lumineszierende Nanopartikel als Nanothermometer , 2011 .

[9]  Tymish Y. Ohulchanskyy,et al.  Combined Optical and MR Bioimaging Using Rare Earth Ion Doped NaYF4 Nanocrystals , 2009 .

[10]  Francisco Sanz-Rodríguez,et al.  Temperature sensing using fluorescent nanothermometers. , 2010, ACS nano.

[11]  Xiaogang Liu,et al.  Upconversion multicolor fine-tuning: visible to near-infrared emission from lanthanide-doped NaYF4 nanoparticles. , 2008, Journal of the American Chemical Society.

[12]  Marco Pedroni,et al.  NIR-to-NIR two-photon excited CaF2:Tm3+,Yb3+ nanoparticles: multifunctional nanoprobes for highly penetrating fluorescence bio-imaging. , 2011, ACS nano.

[13]  Qian Huang,et al.  Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. , 2012, ACS nano.

[14]  Markus P. Hehlen,et al.  Hexagonal Sodium Yttrium Fluoride Based Green and Blue Emitting Upconversion Phosphors , 2004 .

[15]  Juan Wang,et al.  Direct evidence of a surface quenching effect on size-dependent luminescence of upconversion nanoparticles. , 2010, Angewandte Chemie.

[16]  Dan Wang,et al.  Using 915 nm laser excited Tm³+/Er³+/Ho³+- doped NaYbF4 upconversion nanoparticles for in vitro and deeper in vivo bioimaging without overheating irradiation. , 2011, ACS nano.

[17]  D. Gamelin,et al.  Design of luminescent inorganic materials: new photophysical processes studied by optical spectroscopy. , 2000, Accounts of chemical research.

[18]  Xinmai Yang,et al.  Molecular photoacoustic tomography with colloidal nanobeacons. , 2009, Angewandte Chemie.

[19]  Shan Jiang,et al.  Multicolor Core/Shell‐Structured Upconversion Fluorescent Nanoparticles , 2008 .

[20]  Shiwei Wu,et al.  Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals , 2009, Proceedings of the National Academy of Sciences.

[21]  Fang Liu,et al.  NIR light controlled photorelease of siRNA and its targeted intracellular delivery based on upconversion nanoparticles. , 2013, Nanoscale.

[22]  Wei Feng,et al.  Blue-emissive upconversion nanoparticles for low-power-excited bioimaging in vivo. , 2012, Journal of the American Chemical Society.

[23]  Manoj Kumar,et al.  Versatile photosensitizers for photodynamic therapy at infrared excitation. , 2007, Journal of the American Chemical Society.

[24]  A. V. Nechaev,et al.  Quantitative Imaging of Single Upconversion Nanoparticles in Biological Tissue , 2013, PloS one.

[25]  Gregory S Harms,et al.  Upconverting nanoparticles for nanoscale thermometry. , 2011, Angewandte Chemie.

[26]  Hong Yang,et al.  “Pulling” Nanoparticles into Water: Phase Transfer of Oleic Acid Stabilized Monodisperse Nanoparticles into Aqueous Solutions of α-Cyclodextrin , 2003 .

[27]  Kai Yang,et al.  Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy. , 2011, Angewandte Chemie.

[28]  Yong Zhang,et al.  LRET-based biodetection of DNA release in live cells using surface-modified upconverting fluorescent nanoparticles. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[29]  Manojit Pramanik,et al.  In vivo carbon nanotube-enhanced non-invasive photoacoustic mapping of the sentinel lymph node , 2009, Physics in medicine and biology.

[30]  Helmut Schäfer,et al.  Nanopartikel für die Aufwärtskonversion , 2011 .

[31]  Geoffrey A Ozin,et al.  Synthesis of ligand-free colloidally stable water dispersible brightly luminescent lanthanide-doped upconverting nanoparticles. , 2011, Nano letters.

[32]  Samuel Achilefu,et al.  In vivo targeted deep-tissue photodynamic therapy based on near-infrared light triggered upconversion nanoconstruct. , 2013, ACS nano.

[33]  Francisco Sanz-Rodríguez,et al.  Intracellular imaging of HeLa cells by non-functionalized NaYF4 : Er3+, Yb3+ upconverting nanoparticles. , 2010, Nanoscale.

[34]  Tymish Y. Ohulchanskyy,et al.  High contrast in vitro and in vivo photoluminescence bioimaging using near infrared to near infrared up-conversion in Tm3+ and Yb3+ doped fluoride nanophosphors. , 2008, Nano letters.

[35]  Jesse V Jokerst,et al.  Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice. , 2012, ACS nano.

[36]  Matthew O'Donnell,et al.  Photoacoustic imaging of early inflammatory response using gold nanorods , 2007 .

[37]  Liang Yan,et al.  Red-emitting upconverting nanoparticles for photodynamic therapy in cancer cells under near-infrared excitation. , 2013, Small.

[38]  A. Bell.  On the production and reproduction of sound by light , 1880, American Journal of Science.

[39]  Frank C J M van Veggel,et al.  Surface modification of upconverting NaYF4 nanoparticles with PEG-phosphate ligands for NIR (800 nm) biolabeling within the biological window. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[40]  Lihong V. Wang.  Multiscale photoacoustic microscopy and computed tomography. , 2009, Nature photonics.

[41]  V V Moshchalkov,et al.  Optical nanoheater based on the Yb3+-Er3+ co-doped nanoparticles. , 2009, Optics express.

[42]  Hui Guo,et al.  Mesoporous-silica-coated up-conversion fluorescent nanoparticles for photodynamic therapy. , 2009, Small.

[43]  Qian Liu,et al.  18F-Labeled magnetic-upconversion nanophosphors via rare-Earth cation-assisted ligand assembly. , 2011, ACS nano.

[44]  Adam de la Zerda,et al.  Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice. , 2010, Nano letters.

[45]  Zhuang Liu,et al.  Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy. , 2011, Biomaterials.

[46]  Zhuang Liu,et al.  Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery. , 2011, Biomaterials.

[47]  Fang Wang,et al.  Multifunctional core-shell upconverting nanoparticles for imaging and photodynamic therapy of liver cancer cells. , 2012, Chemistry, an Asian journal.

[48]  Muthu Kumara Gnanasammandhan,et al.  In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers , 2012, Nature Medicine.

[49]  S. Emelianov,et al.  Silica-coated gold nanorods as photoacoustic signal nanoamplifiers. , 2011, Nano letters.

[50]  Lihong V. Wang,et al.  Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs , 2012, Science.

[51]  F. Auzel.  Upconversion and anti-Stokes processes with f and d ions in solids. , 2004, Chemical reviews.

[52]  Taeghwan Hyeon,et al.  Nonblinking and Nonbleaching Upconverting Nanoparticles as an Optical Imaging Nanoprobe and T1 Magnetic Resonance Imaging Contrast Agent , 2009 .

[53]  Wing-Cheung Law,et al.  Core/shell NaGdF4:Nd(3+)/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications. , 2012, ACS nano.

[54]  Zhen Cheng,et al.  In vitro and in vivo uncaging and bioluminescence imaging by using photocaged upconversion nanoparticles. , 2012, Angewandte Chemie.

[55]  Jun Lin,et al.  Synthesis of Magnetic, Up‐Conversion Luminescent, and Mesoporous Core–Shell‐Structured Nanocomposites as Drug Carriers , 2010 .

[56]  Lihong V. Wang,et al.  In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. , 2010, Chemical reviews.

[57]  Younan Xia,et al.  Near-infrared gold nanocages as a new class of tracers for photoacoustic sentinel lymph node mapping on a rat model. , 2009, Nano letters.

[58]  Lehui Lu,et al.  A high-performance ytterbium-based nanoparticulate contrast agent for in vivo X-ray computed tomography imaging. , 2012, Angewandte Chemie.