Saliva induces expression of antimicrobial peptides and promotes intracellular killing of bacteria in keratinocytes by epidermal growth factor receptor transactivation

Wounds in the oral cavity, constantly exposed to both saliva and bacteria, heal quickly without infection. Furthermore, during licking of skin wounds, saliva promotes wound healing and plays a role in keeping the wound free of infection.

[1]  K. Reiss,et al.  SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation. , 2014, The Journal of investigative dermatology.

[2]  M. Jontell,et al.  Quantitative detection of epidermal growth factor and interleukin-8 in whole saliva of healthy individuals. , 2014, Journal of immunological methods.

[3]  A. Schmidtchen,et al.  The Epidermal Growth Factor Receptor Is a Regulator of Epidermal Complement Component Expression and Complement Activation , 2014, The Journal of Immunology.

[4]  Robert E. W. Hancock,et al.  Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing. , 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

[5]  W. Wade,et al.  The oral microbiome in health and disease. , 2013, Pharmacological research.

[6]  G. Gimpl,et al.  Unsaturated Fatty Acids Drive Disintegrin and Metalloproteinase (ADAM)-dependent Cell Adhesion, Proliferation, and Migration by Modulating Membrane Fluidity* , 2011, The Journal of Biological Chemistry.

[7]  A. Schmidtchen,et al.  Injury is a major inducer of epidermal innate immune responses during wound healing. , 2010, The Journal of investigative dermatology.

[8]  P. Saftig,et al.  The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions. , 2009, Seminars in cell & developmental biology.

[9]  Shanping Li,et al.  Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column. , 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[10]  K. Sayama,et al.  Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. , 2007, The Journal of investigative dermatology.

[11]  A. Schmidtchen,et al.  Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. , 2006, The Journal of clinical investigation.

[12]  F. Jacobsen,et al.  Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections , 2005, Gene Therapy.

[13]  T. Ganz,et al.  Differential Regulation of β-Defensin Expression in Human Skin by Microbial Stimuli1 , 2005, The Journal of Immunology.

[14]  J. Zuckerman,et al.  Differential Injury Responses in Oral Mucosal and Cutaneous Wounds , 2003, Journal of dental research.

[15]  S. Zahler,et al.  An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. , 2003, The Journal of clinical investigation.

[16]  T. Ganz,et al.  Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors1 , 2003, The Journal of Immunology.

[17]  M. Ståhle-Bäckdahl,et al.  The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. , 2003, The Journal of investigative dermatology.

[18]  K. Waku,et al.  Lysophosphatidic acid, a growth factor-like lipid, in the saliva Published, JLR Papers in Press,September 1, 2002. DOI 10.1194/jlr.M200242-JLR200 , 2002, Journal of Lipid Research.

[19]  R. Siebert,et al.  The novel human beta-defensin-3 is widely expressed in oral tissues. , 2002, European journal of oral sciences.

[20]  M. Zasloff Antimicrobial peptides of multicellular organisms , 2002, Nature.

[21]  Takaaki Ohtake,et al.  Innate antimicrobial peptide protects the skin from invasive bacterial infection , 2001, Nature.

[22]  Y. Matsuzawa,et al.  Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing , 2000, The Journal of cell biology.

[23]  H. Roche,et al.  Unsaturated fatty acids , 1999, Proceedings of the Nutrition Society.

[24]  A. IJzerman,et al.  Inhibition of receptor/G protein coupling by suramin analogues. , 1996, Molecular pharmacology.

[25]  L. Bodner,et al.  Extraction wound healing in desalivated rats. , 1991, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[26]  J. Hornung,et al.  Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line , 1988, The Journal of cell biology.

[27]  R. Farr,et al.  The presence of platelet-activating factor (PAF) in normal human mixed saliva. , 1981, Journal of Immunology.

[28]  J. Hutson,et al.  Effect of salivary glands on wound contraction in mice , 1979, Nature.

[29]  P. Stephens,et al.  Scarless healing: Oral mucosa as a scientific model , 2009 .

[30]  A. Cole,et al.  Antimicrobial peptides in innate immune responses. , 2008, Contributions to microbiology.

[31]  F. Larcher,et al.  In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37. , 2008, The Journal of investigative dermatology.

[32]  C. Blobel,et al.  ADAMs: key components in EGFR signalling and development , 2005, Nature Reviews Molecular Cell Biology.

[33]  A V Nieuw Amerongen,et al.  Saliva--the defender of the oral cavity. , 2002, Oral diseases.

[34]  P. Carmeliet,et al.  PR39, a peptide regulator of angiogenesis , 2000, Nature Medicine.

[35]  L. Kjeldsen,et al.  Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils. , 1996, Journal of immunological methods.

[36]  G. Olivecrona,et al.  Lipids in human saliva. , 1996, Archives of oral biology.

[37]  L. Bodner,et al.  Effect of parotid submandibular and sublingual saliva on wound healing in rats. , 1991, Comparative biochemistry and physiology. A, Comparative physiology.

[38]  E. Corey,et al.  Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva. , 1983, Archives of oral biology.