Ang2/Fat-Free Is a Conserved Subunit of the Golgi-associated Retrograde Protein Complex

The protein Ang2 is shown to be a conserved component of the Golgi-associated Retrograde Protein (GARP) complex in higher eukaryotes. Ang2 participates in retrograde transport from endosomes to the TGN, contributing to the maintenance of acid hydrolase sorting, lysosome function and autophagy.

[1]  Javier G. Magadán,et al.  Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex , 2010, Proceedings of the National Academy of Sciences.

[2]  Javier G. Magadán,et al.  Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps , 2010, PLoS pathogens.

[3]  J. Bonifacino,et al.  Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. , 2010, Developmental cell.

[4]  J. Bonifacino,et al.  Dual Roles of the Mammalian GARP Complex in Tethering and SNARE Complex Assembly at the trans-Golgi Network , 2009, Molecular and Cellular Biology.

[5]  A. Gitler,et al.  TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity* , 2009, The Journal of Biological Chemistry.

[6]  S. Walkley,et al.  Secondary lipid accumulation in lysosomal disease. , 2009, Biochimica et biophysica acta.

[7]  B. Citron,et al.  Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein , 2009, Neuroscience.

[8]  Narmada Thanki,et al.  CDD: specific functional annotation with the Conserved Domain Database , 2008, Nucleic Acids Res..

[9]  J. Bonifacino,et al.  Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7 , 2008, The Journal of cell biology.

[10]  J. Bonifacino,et al.  Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes. , 2008, Molecular biology of the cell.

[11]  K. Oegema,et al.  MVB-12, a Fourth Subunit of Metazoan ESCRT-I, Functions in Receptor Downregulation , 2007, PloS one.

[12]  S. Young,et al.  ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration , 2007, Current Biology.

[13]  J. Bonifacino,et al.  The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting. , 2007, Molecular biology of the cell.

[14]  S. Gygi,et al.  Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. , 2007, Cell host & microbe.

[15]  H. Cai,et al.  Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. , 2007, Developmental cell.

[16]  J. Collinge,et al.  ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B) , 2006, Neurology.

[17]  D. Klionsky,et al.  Atg9 sorting from mitochondria is impaired in early secretion and VFT-complex mutants in Saccharomyces cerevisiae , 2006, Journal of Cell Science.

[18]  Hideyuki Okano,et al.  Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice , 2006, Nature.

[19]  Masaaki Komatsu,et al.  Loss of autophagy in the central nervous system causes neurodegeneration in mice , 2006, Nature.

[20]  J. Bonifacino,et al.  The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain , 2006, Nature Structural &Molecular Biology.

[21]  M. Pack,et al.  Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure. , 2006, Cell metabolism.

[22]  P. Evans,et al.  Structural Analysis of the Interaction Between the SNARE Tlg1 and Vps51 , 2006, Traffic.

[23]  G. Bjørkøy,et al.  p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death , 2005, The Journal of cell biology.

[24]  A. Lengeling,et al.  Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse , 2005, Nature Genetics.

[25]  R. Schwarzenbacher,et al.  Characterization of the human GARP (Golgi associated retrograde protein) complex. , 2005, Experimental cell research.

[26]  T. Stevens,et al.  Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE Tlg1p. , 2003, Molecular biology of the cell.

[27]  Daniel J Klionsky,et al.  Vps51 Is Part of the Yeast Vps Fifty-three Tethering Complex Essential for Retrograde Traffic from the Early Endosome and Cvt Vesicle Completion* , 2003, The Journal of Biological Chemistry.

[28]  H. Pelham,et al.  Vps51p Links the VFT Complex to the SNARE Tlg1p* , 2002, The Journal of Biological Chemistry.

[29]  D. Price,et al.  Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues , 2001, Neurobiology of Disease.

[30]  H. Pelham,et al.  An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes , 2001, The EMBO journal.

[31]  S. Munro,et al.  The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. , 2001, Developmental cell.

[32]  M. Halpern,et al.  Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters , 2001, Science.

[33]  Takeshi Noda,et al.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.

[34]  W. V. D. Van de Ven,et al.  Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13. , 1998, Genomics.

[35]  T. Coelho-Sampaio,et al.  A novel methodology for the investigation of intracellular proteolytic processing in intact cells. , 1998, European journal of cell biology.

[36]  J. Bonifacino,et al.  β3A-adaptin, a Subunit of the Adaptor-like Complex AP-3* , 1997, The Journal of Biological Chemistry.

[37]  A. Lupas,et al.  Predicting coiled coils from protein sequences , 1991, Science.

[38]  K. J. Monty,et al.  Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. , 1966, Biochimica et biophysica acta.

[39]  A. Ballabio Disease pathogenesis explained by basic science: lysosomal storage diseases as autophagocytic disorders. , 2009, International journal of clinical pharmacology and therapeutics.

[40]  T. Stevens,et al.  Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. , 2000, Molecular biology of the cell.