Fiber optic sensors for sub-centimeter spatially resolved measurements: Review and biomedical applications

Abstract One of the current frontier of optical fiber sensors, and a unique asset of this sensing technology is the possibility to use a whole optical fiber, or optical fiber device, as a sensor. This solution allows shifting the whole sensing paradigm, from the measurement of a single physical parameter (such as temperature, strain, vibrations, pressure) to the measurement of a spatial distribution, or profiling, of a physical parameter along the fiber length. In the recent years, several technologies are achieving this task with unprecedentedly narrow spatial resolution, ranging from the sub-millimeter to the centimeter-level. In this work, we review the main fiber optic sensing technologies that achieve a narrow spatial resolution: Fiber Bragg Grating (FBG) dense arrays, chirped FBG (CFBG) sensors, optical frequency domain reflectometry (OFDR) based on either Rayleigh scattering or reflective elements, and microwave photonics (MWP). In the second part of the work, we present the impact of spatially dense fiber optic sensors in biomedical applications, where they find the main impact, presenting the key results obtained in thermo-therapies monitoring, high-resolution diagnostic, catheters monitoring, smart textiles, and other emerging applicative fields.

[1]  Martin Wolf,et al.  Body‐Monitoring and Health Supervision by Means of Optical Fiber‐Based Sensing Systems in Medical Textiles , 2015, Advanced healthcare materials.

[2]  Agostino Iadicicco,et al.  Temperature profile of ex-vivo organs during radio frequency thermal ablation by fiber Bragg gratings , 2016, Journal of biomedical optics.

[3]  Christopher L Brace,et al.  Principles of and advances in percutaneous ablation. , 2011, Radiology.

[4]  Guido Perrone,et al.  Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during in vivo laser ablations of biological tissue , 2017, Journal of biomedical optics.

[5]  D. Kinet,et al.  Smart medical textiles with embedded optical fibre sensors for continuous monitoring of respiratory movements during MRI , 2010, European Workshop on Optical Fibre Sensors.

[6]  Hui Yang,et al.  Intensity-Modulated Microbend Fiber Optic Sensor for Respiratory Monitoring and Gating During MRI , 2013, IEEE Transactions on Biomedical Engineering.

[7]  Orlando Frazão,et al.  Review of fiber-optic pressure sensors for biomedical and biomechanical applications , 2013, Journal of biomedical optics.

[8]  Emiliano Schena,et al.  Endoscopic ultrasound-guided Nd:YAG laser ablation of recurrent pancreatic neuroendocrine tumor: a promising revolution? , 2014, Endoscopy.

[9]  Zhiwen Liu,et al.  An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure , 2012, Biomedical microdevices.

[10]  Shikha Ambastha,et al.  Spinal needle force monitoring during lumbar puncture using fiber Bragg grating force device , 2016, Journal of biomedical optics.

[11]  Sergio Silvestri,et al.  A Needlelike Probe for Temperature Monitoring During Laser Ablation Based on Fiber Bragg Grating: Manufacturing and Characterization , 2015 .

[12]  Lin Zhang,et al.  In-fiber Bragg-grating temperature sensor system for medical applications , 1997 .

[13]  Sergio Silvestri,et al.  Techniques for temperature monitoring during laser-induced thermotherapy: An overview , 2013, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[14]  E. Schena,et al.  Laser Ablation for Cancer: Past, Present and Future , 2017, Journal of functional biomaterials.

[15]  M D Sherar,et al.  Temperature measurement artefacts of thermocouples and fluoroptic probes during laser irradiation at 810 nm. , 2001, Physics in medicine and biology.

[16]  Jan Nedoma,et al.  A Non-Invasive Multichannel Hybrid Fiber-Optic Sensor System for Vital Sign Monitoring , 2017, Sensors.

[17]  T. Dubinsky,et al.  High-intensity focused ultrasound: current potential and oncologic applications. , 2008, AJR. American journal of roentgenology.

[18]  Gian-Luca Bona,et al.  An Optical Fibre-Based Sensor for Respiratory Monitoring , 2014, Sensors.

[19]  Elizabeth K Rasch,et al.  If We Build It, Who Will Come?: Working-Age Adults With Chronic Health Care Needs and the Medical Home , 2011, Medical care.

[20]  David J. Webb,et al.  Optical in-fiber bragg grating sensor systems for medical applications. , 1998, Journal of biomedical optics.

[21]  Guido Perrone,et al.  Detection of thermal gradients through fiber-optic Chirped Fiber Bragg Grating (CFBG): Medical thermal ablation scenario , 2018 .

[22]  Liang Chen,et al.  Recent Progress in Distributed Fiber Optic Sensors , 2012, Sensors.

[23]  Emiliano Schena,et al.  Medical Smart Textiles Based on Fiber Optic Technology: An Overview , 2015, Journal of functional biomaterials.

[24]  Elfed Lewis,et al.  Fiber-optic chirped FBG for distributed thermal monitoring of ex-vivo radiofrequency ablation of liver. , 2014, Biomedical optics express.

[25]  Antonello Cutolo,et al.  Optical Guidance Systems for Epidural Space Identification , 2017, IEEE Journal of Selected Topics in Quantum Electronics.

[26]  Xiaotian Zou,et al.  Miniature Fabry–Perot Fiber Optic Sensor for Intravascular Blood Temperature Measurements , 2013, IEEE Sensors Journal.

[27]  P. Dinning,et al.  In-vivo demonstration of a high resolution optical fiber manometry catheter for diagnosis of gastrointestinal motility disorders. , 2009, Optics express.

[28]  Emiliano Schena,et al.  Optical Fiber-Based MR-Compatible Sensors for Medical Applications: An Overview , 2013, Sensors.

[29]  Elfed Lewis,et al.  Monitoring of radiofrequency thermal ablation in liver tissue through fibre Bragg grating sensors array , 2014 .

[30]  Elfed Lewis,et al.  Differential in vivo urodynamic measurement in a single thin catheter based on two optical fiber pressure sensors , 2015, Journal of biomedical optics.

[31]  José Higino Correia,et al.  Simultaneous cardiac and respiratory frequency measurement based on a single fiber Bragg grating sensor , 2011 .

[32]  T. Flohr,et al.  Feasibility of computed tomography based thermometry during interstitial laser heating in bovine liver , 2011, European Radiology.

[33]  Łukasz Dziuda,et al.  Fiber-optic sensors for monitoring patient physiological parameters: a review of applicable technologies and relevance to use during magnetic resonance imaging procedures , 2015, Journal of biomedical optics.

[34]  D. J. Webb,et al.  Chirped Bragg Gratings in PMMA Step-Index Polymer Optical Fiber , 2017, IEEE Photonics Technology Letters.

[35]  S. J. Cala,et al.  Chest wall and lung volume estimation by optical reflectance motion analysis. , 1996, Journal of applied physiology.

[36]  Li Xia,et al.  Ultra-short FBG based distributed sensing using shifted optical Gaussian filters and microwave-network analysis. , 2016, Optics express.

[37]  Elfed Lewis,et al.  Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution , 2014, Journal of biomedical optics.

[38]  P. Dinning,et al.  Design of a high-sensor count fibre optic manometry catheter for in-vivo colonic diagnostics. , 2009, Optics express.

[39]  Victor Lambin Iezzi,et al.  Enhancement of accuracy in shape sensing of surgical needles using optical frequency domain reflectometry in optical fibers. , 2017, Biomedical optics express.

[40]  G. Heyndrickx,et al.  Coronary Thermodilution to Assess Flow Reserve: Experimental Validation , 2001, Circulation.

[41]  Elfed Lewis,et al.  Fiber Optic Sensors for Temperature Monitoring during Thermal Treatments: An Overview , 2016, Sensors.

[42]  R Jason Stafford,et al.  Laser-induced thermal therapy for tumor ablation. , 2010, Critical reviews in biomedical engineering.

[43]  Sergio Silvestri,et al.  Theoretical Analysis and Experimental Evaluation of Laser-Induced Interstitial Thermotherapy in Ex Vivo Porcine Pancreas , 2012, IEEE Transactions on Biomedical Engineering.

[44]  J. Hervás,et al.  [INVITED] Cascade FBGs distributed sensors interrogation using microwave photonics filtering techniques , 2016 .

[45]  G Brix,et al.  Quantitative MR temperature monitoring of high-intensity focused ultrasound therapy. , 1999, Magnetic resonance imaging.

[46]  E Schena,et al.  Experimental assessment of CT-based thermometry during laser ablation of porcine pancreas , 2013, Physics in medicine and biology.

[47]  D. Formica,et al.  Smart Textile Based on Fiber Bragg Grating Sensors for Respiratory Monitoring: Design and Preliminary Trials , 2015, Biosensors.

[48]  S. Selleri,et al.  Modal analysis in 2D media with variable disorder. , 2015, Optics express.

[49]  William B. Spillman,et al.  Fiber optic sensors : an introduction for engineers and scientists , 2011 .

[50]  N. Spratt,et al.  Epidural intracranial pressure measurement in rats using a fiber-optic pressure transducer. , 2012, Journal of visualized experiments : JoVE.

[51]  M. Froggatt,et al.  High-spatial-resolution distributed strain measurement in optical fiber with rayleigh scatter. , 1998, Applied optics.

[52]  Xueguang Qiao,et al.  Compact Optical Fiber 3D Shape Sensor Based on a Pair of Orthogonal Tilted Fiber Bragg Gratings , 2015, Scientific Reports.

[53]  J. Peterson,et al.  Fiber-optic sensors for biomedical applications. , 1984, Science.

[54]  F. Pirotte,et al.  Optical Fiber Sensors Embedded Into Medical Textiles for Healthcare Monitoring , 2008, IEEE Sensors Journal.

[55]  S. Selleri,et al.  Analysis of mid-infrared lasing in active random media. , 2015, Optics express.

[56]  Emiliano Schena,et al.  Assessment of temperature measurement error and its correction during Nd:YAG laser ablation in porcine pancreas , 2014, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[57]  Andreas Othonos,et al.  Bragg Gratings in Optical Fibers: Fundamentals and Applications , 2000 .

[58]  P. Beard,et al.  A Fabry-Perot fiber-optic ultrasonic hydrophone for the simultaneous measurement of temperature and acoustic pressure. , 2009, The Journal of the Acoustical Society of America.

[59]  Salvador Sales,et al.  Long Weak FBG Sensor Interrogation Using Microwave Photonics Filtering Technique , 2014, IEEE Photonics Technology Letters.

[60]  J. Capmany,et al.  Long fiber Bragg grating sensor interrogation using discrete-time microwave photonic filtering techniques. , 2013, Optics express.

[61]  Thierry F. Taunay,et al.  Continuous Multicore Optical Fiber Grating Arrays for Distributed Sensing Applications , 2017, Journal of Lightwave Technology.

[62]  Emiliano Schena,et al.  Smart textile for respiratory monitoring and thoraco‐abdominal motion pattern evaluation , 2018, Journal of biophotonics.

[63]  D. Christensen,et al.  Multiple Sensor Optical Thermometry System for Application in Clinical Hyperthermia , 1984, IEEE Transactions on Biomedical Engineering.

[64]  K. Hill,et al.  Fiber Bragg grating technology fundamentals and overview , 1997 .

[65]  Emiliano Schena,et al.  Smart Textile Based on 12 Fiber Bragg Gratings Array for Vital Signs Monitoring , 2017, IEEE Sensors Journal.

[66]  J. Chapelon,et al.  High-intensity focused ultrasound ablation of thyroid nodules: first human feasibility study. , 2011, Thyroid : official journal of the American Thyroid Association.

[67]  Sergio Silvestri,et al.  Temperature monitoring and lesion volume estimation during double-applicator laser-induced thermotherapy in ex vivo swine pancreas: a preliminary study , 2014, Lasers in Medical Science.

[68]  Nick Todd,et al.  In vivo evaluation of multi‐echo hybrid PRF/T1 approach for temperature monitoring during breast MR‐guided focused ultrasound surgery treatments , 2014, Magnetic resonance in medicine.

[69]  Enbang Li,et al.  Wearable sensors in intelligent clothing for measuring human body temperature based on optical fiber Bragg grating. , 2012, Optics express.

[70]  Daniele Tosi,et al.  Review and Analysis of Peak Tracking Techniques for Fiber Bragg Grating Sensors , 2017, Sensors.

[71]  Elfed Lewis,et al.  Optical Fibre Pressure Sensors in Medical Applications , 2015, Sensors.

[72]  R. J. Black,et al.  Real-Time Estimation of 3-D Needle Shape and Deflection for MRI-Guided Interventions , 2010, IEEE/ASME Transactions on Mechatronics.

[73]  D Herranz,et al.  Novel catheter enabling simultaneous radiofrequency ablation and optical coherence reflectometry. , 2015, Biomedical optics express.

[74]  J. W. Arkwright,et al.  Measurement of Muscular Activity Associated With Peristalsis in the Human Gut Using Fiber Bragg Grating Arrays , 2012, IEEE Sensors Journal.

[75]  Kim Butts Pauly,et al.  MR thermometry , 2008, Journal of magnetic resonance imaging : JMRI.

[76]  Charles G. Askins,et al.  Shape sensing using distributed fiber optic strain measurements , 2004, European Workshop on Optical Fibre Sensors.

[77]  Sergio Silvestri,et al.  Optoelectronic Plethysmography in Clinical Practice and Research: A Review , 2017, Respiration.

[78]  Ivana Gasulla,et al.  Spatial Division Multiplexed Microwave Signal processing by selective grating inscription in homogeneous multicore fibers , 2017, Scientific Reports.

[79]  Ting Wang,et al.  Advanced Spatial-Division Multiplexed Measurement Systems Propositions—From Telecommunication to Sensing Applications: A Review , 2016, Sensors.

[80]  M. Froggatt,et al.  Distributed measurement of the complex modulation of a photoinduced Bragg grating in an optical fiber. , 1996, Applied optics.

[81]  Kay Schuster,et al.  Trends and future of fiber Bragg grating sensing technologies: tailored draw tower gratings (DTGs) , 2014, Photonics Europe.

[82]  Sergio Silvestri,et al.  CT-based thermometry: An overview , 2014, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[83]  E Schena,et al.  Magnetic resonance-based thermometry during laser ablation on ex-vivo swine pancreas and liver. , 2015, Medical engineering & physics.

[84]  E Schena,et al.  Temperature monitoring during microwave ablation in ex vivo porcine livers. , 2015, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[85]  Stephen T. Kreger,et al.  Swept-wavelength interferometric interrogation of fiber Rayleigh scatter for distributed sensing applications , 2007, SPIE Optics East.

[86]  Antonello Cutolo,et al.  Lab in a needle for epidural space identification , 2016, European Workshop on Optical Fibre Sensors.

[87]  Emiliano Schena,et al.  Design and Feasibility Assessment of a Magnetic Resonance-Compatible Smart Textile Based on Fiber Bragg Grating Sensors for Respiratory Monitoring , 2016, IEEE Sensors Journal.

[88]  K. Krebber,et al.  Medical Textiles With Embedded Fiber Optic Sensors for Monitoring of Respiratory Movement , 2012, IEEE Sensors Journal.

[89]  R. Salomir,et al.  Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage , 2015, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[90]  Wook Jae Yoo,et al.  Development of Respiration Sensors Using Plastic Optical Fiber for Respiratory Monitoring Inside MRI System , 2010 .

[91]  Emiliano Schena,et al.  Error of a Temperature Probe for Cancer Ablation Monitoring Caused by Respiratory Movements: Ex Vivo and In Vivo Analysis , 2016, IEEE Sensors Journal.

[92]  Łukasz Dziuda,et al.  Fiber Bragg grating-based sensor for monitoring respiration and heart activity during magnetic resonance imaging examinations , 2013, Journal of biomedical optics.

[93]  Faisal Rafiq Mahmad Adikan,et al.  The Use of Fiber Bragg Grating Sensors in Biomechanics and Rehabilitation Applications: The State-of-the-Art and Ongoing Research Topics , 2012, Sensors.

[94]  T. Erdogan Fiber grating spectra , 1997 .

[95]  Michael A. Davis,et al.  Fiber grating sensors , 1997 .

[96]  Mariusz Krej,et al.  Monitoring Respiration and Cardiac Activity Using Fiber Bragg Grating-Based Sensor , 2012, IEEE Transactions on Biomedical Engineering.

[97]  Matthew D. Rogge,et al.  Shape sensing using multi-core fiber optic cable and parametric curve solutions. , 2012, Optics express.

[98]  Mariusz Krej,et al.  A Method of Detecting Heartbeat Locations in the Ballistocardiographic Signal From the Fiber-Optic Vital Signs Sensor , 2015, IEEE Journal of Biomedical and Health Informatics.