The long and winding road leading to the identification of the hepatitis C virus.

[1]  R. Dwek,et al.  The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy , 2009, Proceedings of the National Academy of Sciences.

[2]  Charles M. Rice,et al.  Human occludin is a hepatitis C virus entry factor required for infection of mouse cells , 2009, Nature.

[3]  T. Umemura,et al.  Epidemiology of hepatocellular carcinoma in Japan , 2009, Journal of Gastroenterology.

[4]  C. Rice,et al.  CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells , 2009, The Journal of general virology.

[5]  S. Quake,et al.  Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis , 2008, Nature Biotechnology.

[6]  T. Tellinghuisen,et al.  Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein , 2008, PLoS pathogens.

[7]  Ralf Bartenschlager,et al.  Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81 , 2007, Hepatology.

[8]  C. Rice,et al.  Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies. , 2007, Vaccine.

[9]  J. McKeating,et al.  Hepatitis C virus cell‐cell transmission in hepatoma cells in the presence of neutralizing antibodies , 2007, Hepatology.

[10]  R. Purcell,et al.  Cytoplasmic Tubular Structures in Liver of HBsAg Carrier Chimpanzees Infected with Delta Agent and Comparison with Cytoplasmic Structures in Non‐A, Non‐B Hepatitis , 2007, Hepatology.

[11]  Chris Sander,et al.  Cellular cofactors affecting hepatitis C virus infection and replication , 2007, Proceedings of the National Academy of Sciences.

[12]  F. Penin,et al.  Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions , 2007, PLoS pathogens.

[13]  Christopher T. Jones,et al.  Hepatitis C Virus p7 and NS2 Proteins Are Essential for Production of Infectious Virus , 2007, Journal of Virology.

[14]  Charles M. Rice,et al.  Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry , 2007, Nature.

[15]  A. Folgori,et al.  A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees , 2006, Nature Medicine.

[16]  M. Houghton,et al.  Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[17]  N. Enomoto,et al.  Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins. , 2005, Gastroenterology.

[18]  M. Houghton,et al.  Prospects for a vaccine against the hepatitis C virus , 2005, Nature.

[19]  K. Shimotohno,et al.  Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. , 2005, Molecular cell.

[20]  R. Bartenschlager,et al.  Production of infectious hepatitis C virus in tissue culture from a cloned viral genome , 2005, Nature Medicine.

[21]  C. Walker,et al.  Mutational escape from CD8+ T cell immunity , 2005, The Journal of experimental medicine.

[22]  D. Ho,et al.  Diverse Hepatitis C Virus Glycoproteins Mediate Viral Infection in a CD81-Dependent Manner , 2004, Journal of Virology.

[23]  J. McHutchison,et al.  Initial treatment for chronic hepatitis C: current therapies and their optimal dosing and duration. , 2004, Cleveland Clinic journal of medicine.

[24]  S. Evans,et al.  The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine , 2003, FEBS letters.

[25]  P. Farci,et al.  Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome [Science 1989;244:359-362]. , 2002, Journal of hepatology.

[26]  C. Tseng,et al.  Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions , 2002, The Journal of experimental medicine.

[27]  S. Nuti,et al.  Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein , 2002, The Journal of experimental medicine.

[28]  S. Levy,et al.  The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis. , 2001, Blood.

[29]  M. Houghton,et al.  Intrahepatic Genetic Inoculation of Hepatitis C Virus RNA Confers Cross-Protective Immunity , 2001, Journal of Virology.

[30]  M. Houghton,et al.  Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection , 2001, Hepatology.

[31]  C. Rice,et al.  Efficient initiation of HCV RNA replication in cell culture. , 2000, Science.

[32]  R. Bartenschlager,et al.  Replication of hepatitis C virus. , 2000, The Journal of general virology.

[33]  J. Silver,et al.  Replication of Subgenomic Hepatitis C Virus Rnas in a Hepatoma Cell Line , 1999 .

[34]  M. Houghton,et al.  Binding of hepatitis C virus to CD81. , 1998, Science.

[35]  R. Bartenschlager,et al.  Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity , 1997, Journal of virology.

[36]  G. Boiteau,et al.  J. Virol. Methods , 1996, Journal of Virological Methods.

[37]  P. Simmonds.  Variability of hepatitis C virus , 1995, Hepatology.

[38]  R. Purcell,et al.  Sequence analysis of the core gene of 14 hepatitis C virus genotypes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[39]  A. Weiner,et al.  Vaccination of chimpanzees against infection by the hepatitis C virus. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[40]  R. Purcell,et al.  Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children , 1994, The Lancet.

[41]  C. Rice,et al.  A second hepatitis C virus-encoded proteinase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[42]  C. Rice,et al.  Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes , 1993, Journal of virology.

[43]  N. Kato,et al.  Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus , 1993, Journal of virology.

[44]  C. Rice,et al.  Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites , 1993, Journal of virology.

[45]  M. Houghton,et al.  The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor. , 1993, Biochemical and biophysical research communications.

[46]  R. Purcell,et al.  Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes , 1993, Journal of virology.

[47]  A. Prince,et al.  Immunity in hepatitis C infection. , 1992, The Journal of infectious diseases.

[48]  P. Barr,et al.  Genetic organization and diversity of the hepatitis C virus. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[49]  T. Sugimura,et al.  Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[50]  H J Alter,et al.  An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. , 1990, Science.

[51]  M. Houghton,et al.  Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: application to diagnosis and blood screening for posttransfusion hepatitis. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[52]  M. Houghton,et al.  A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. , 1989, Nucleic acids research.

[53]  T. Shikata,et al.  Production of antibodies directed against microtubular aggregates in hepatocytes of chimpanzees with non-A, non-B hepatitis. , 1989, The Journal of general virology.

[54]  M. Houghton,et al.  Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. , 1989, Science.

[55]  L. Seeff,et al.  Transfusion-associated non-A, non-B hepatitis. Where do we go from here? , 1988, Gastroenterology.

[56]  L. Seeff,et al.  Transfusion-associated non-A, non-B hepatitis , 1988 .

[57]  M. Houghton,et al.  A single antigenomic open reading frame of the hepatitis delta virus encodes the epitope(s) of both hepatitis delta antigen polypeptides p24 delta and p27 delta , 1988, Journal of virology.

[58]  M. Shapiro,et al.  Determining the size of non-A, non-B hepatitis virus by filtration. , 1987, The Journal of infectious diseases.

[59]  M. Houghton,et al.  Hepatitis delta (δ) cDNA clones: Undetectable hybridization to nucleic acids from infectious non‐A, non‐B hepatitis materials and hepatitis B DNA , 1987, Journal of medical virology.

[60]  Michael Houghton,et al.  Structure, sequence and expression of the hepatitis delta (δ) viral genome , 1986, Nature.

[61]  J. Gerin,et al.  Cloned fragment of the hepatitis delta virus RNA genome: sequence and diagnostic application. , 1986, Science.

[62]  H. Alter,et al.  Non-A, Non-B Hepatitis: Evolving Epidemiologic and Clinical Perspective , 1986, Seminars in liver disease.

[63]  T. Shikata,et al.  Production of antibody associated with non-A, non-B hepatitis in a chimpanzee lymphoblastoid cell line established by in vitro transformation with Epstein-Barr virus. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[64]  D. Bradley.  The agents of non-A, non-B viral hepatitis , 1985, Journal of Virological Methods.

[65]  A. A. Eddy,et al.  Note added in proof: Mechanisms of solute transport in selected eukaryotic micro-organisms , 1982 .

[66]  A. Prince,et al.  ISOLATION OF A VIRUS FROM CHIMPANZEE LIVER CELL CULTURES INOCULATED WITH SERA CONTAINING THE AGENT OF NON-A, NON-B HEPATITIS , 1984, The Lancet.

[67]  S. Iwarson,et al.  DETECTION OF REVERSE TRANSCRIPTASE ACTIVITY IN ASSOCIATION WITH THE NON-A, NON-B HEPATITIS AGENT(S) , 1984, The Lancet.

[68]  D. Bradley,et al.  Posttransfusion Non-A, Non-B Hepatitis: Physicochemical Properties of Two Distinct Agents , 1983, The Journal of infectious diseases.

[69]  R. Purcell,et al.  Inactivation of hepatitis B virus and non-A, non-B hepatitis by chloroform , 1983, Infection and immunity.

[70]  R. W. Davis,et al.  Efficient isolation of genes by using antibody probes. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[71]  R. Purcell,et al.  Non-A, non-B hepatitis in chimpanzees and marmosets. , 1981, The Journal of infectious diseases.

[72]  I. Jackson,et al.  The absence of introns within a human fibroblast interferon gene. , 1981, Nucleic acids research.

[73]  W. Szmuness,et al.  Transfusion-transmitted viruses study: experimental evidence for two non-A, non-B, hepatitis agents. , 1980, The Journal of infectious diseases.

[74]  J. Emtage,et al.  The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers. , 1980, Nucleic acids research.

[75]  R. Purcell,et al.  Non-A, non-B hepatitis: ultrastructural evidence for two agents in experimentally infected chimpanzees. , 1979, Science.

[76]  W. Gilbert,et al.  Immunological screening method to detect specific translation products. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[77]  R. Purcell,et al.  TRANSMISSIBLE AGENT IN NON-A, NON-B HEPATITIS , 1978, The Lancet.

[78]  M. Rizzetto,et al.  Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. , 1977, Gut.

[79]  R. Purcell,et al.  Hepatitis A: Detection by Immune Electron Microscopy of a Viruslike Antigen Associated with Acute Illness , 1973, Science.

[80]  M. Bayer,et al.  Particles associated with Australia Antigen in the Sera of Patients with Leukaemia, Down's Syndrome and Hepatitis , 1968, Nature.

[81]  S. Krugman,et al.  The natural history of infectious hepatitis. , 1962, The American journal of medicine.

[82]  M. Gale,et al.  Viral regulation and evasion of the host response. , 2007, Current topics in microbiology and immunology.

[83]  T. Gojobori,et al.  Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization , 1998, Archives of Virology.

[84]  R. Esteban,et al.  Epidemiology of hepatitis C virus infection. , 1993, Journal of hepatology.

[85]  G. Kroemer,et al.  Mechanisms of self tolerance. , 1992, Immunology today.

[86]  D. Bradley.  Hepatitis non-A, non-B viruses become identified as hepatitis C and E viruses. , 1990, Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progres en virologie medicale.

[87]  M. Houghton,et al.  Structure, sequence and expression of the hepatitis delta (delta) viral genome. , 1986, Nature.

[88]  Altermatt Hj,et al.  Non-A, non-B hepatitis: advances and unfulfilled expectations of the first decade. , 1986, Progress in liver diseases.

[89]  H. Alter,et al.  Non-A, non-B hepatitis: advances and unfulfilled expectations of the first decade. , 1986, Progress in liver diseases.

[90]  M. Rizzetto,et al.  Delta hepatitis--present status. , 1985, Journal of hepatology.

[91]  M. Alter,et al.  The epidemiology of non-A, non-B hepatitis in the United States. , 1985, Progress in clinical and biological research.

[92]  H. Alter.  The dominant role of non-A, non-B in the pathogenesis of post-transfusion hepatitis: a clinical assessment. , 1980, Clinics in gastroenterology.

[93]  Altermatt Hj.  The dominant role of non-A, non-B in the pathogenesis of post-transfusion hepatitis: a clinical assessment. , 1980 .

[94]  W. Szmuness,et al.  Non-A, non-B hepatitis transmission in chimpanzees: a project of the transfusion-transmitted viruses study group. , 1978, Intervirology.

[95]  R. Purcell,et al.  Transfusion‐associated hepatitis not due to viral hepatitis type A or B † , 1975, The New England journal of medicine.

[96]  R. Williams.  Letter: Polymyalgia rheumatica and liver disease. , 1974, Lancet.