Sex differences in resting-state neural correlates of openness to experience among older adults.

We investigated sex differences in the resting-state neural correlates of Openness to Experience, a universal personality trait defined by cognitive flexibility, attention to feelings, creativity, and preference for novelty. Using resting-state positron-emission tomography from 100 older individuals (>55 years of age), we identified associations between Openness and resting-state regional cerebral blood flow that replicated across 2 assessments of the same sample, approximately 2 years apart. Openness correlated positively with prefrontal activity in women, anterior cingulate activity in men, and orbitofrontal activity in both sexes, which suggests that areas linked to cognitive flexibility (women), monitoring processes (men), and reward and emotional processing (both) underlie individual differences in Openness. The results challenge the implicit assumption that the same trait will rely on the same neural mechanisms across all who express it.

[1]  S. Vanheule,et al.  Alexithymia and interpersonal problems. , 2007, Journal of clinical psychology.

[2]  Christer Halldin,et al.  Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET , 2008, NeuroImage.

[3]  B. Bermond,et al.  Cognitive and emotional characteristics of alexithymia: a review of neurobiological studies. , 2003, Journal of psychosomatic research.

[4]  D. Levine,et al.  A neuropsychological theory of positive affect and its influence on cognition. , 1999, Psychological review.

[5]  David Arenberg,et al.  Normal Human Aging: The Baltimore Longitudinal Study on Aging , 1984 .

[6]  P. Costa,et al.  Revised NEO Personality Inventory (NEO-PI-R) and NEO-Five-Factor Inventory (NEO-FFI) , 1992 .

[7]  Jordan B. Peterson,et al.  Sources of openness/intellect: cognitive and neuropsychological correlates of the fifth factor of personality. , 2005, Journal of personality.

[8]  Jordan B Peterson,et al.  Prefrontal cognitive ability, intelligence, Big Five personality, and the prediction of advanced academic and workplace performance. , 2007, Journal of personality and social psychology.

[9]  Roberto Cabeza,et al.  Aging Gracefully: Compensatory Brain Activity in High-Performing Older Adults , 2002, NeuroImage.

[10]  R. McCrae.  Social consequences of experiential openness. , 1996, Psychological bulletin.

[11]  Dirk Hagemann,et al.  Individual difference variables, affective differentiation, and the structures of affect. , 2003, Journal of personality.

[12]  Timothy C. Bates,et al.  Crystallized intelligence as a product of speed and drive for experience: the relationship of inspection time and openness to g and Gc , 2003 .

[13]  R. Zatorre,et al.  Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[14]  A. Jula,et al.  Alexithymia and Somatization in General Population , 2008, Psychosomatic medicine.

[15]  David C. Funder,et al.  Lay Conceptions of the Five-Factor Model and its Indicators , 1998 .

[16]  G. J. Vries,et al.  Minireview: Sex differences in adult and developing brains: compensation, compensation, compensation. , 2004 .

[17]  P. Costa,et al.  Conceptions and correlates of openness to experience. , 1997 .

[18]  H. Wagner,et al.  Relation between alexithymia and the five-factor model of personality: a facet-level analysis. , 1999, Journal of personality assessment.

[19]  K. Cosgrove,et al.  Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry , 2007, Biological Psychiatry.

[20]  J. Pardo,et al.  Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Bradford C. Dickerson,et al.  Neuroanatomical correlates of personality in the elderly , 2007, NeuroImage.

[22]  Simon Vogrin,et al.  Cerebral cortex: An MRI-based study of volume and variance with age and sex , 2006, Journal of Clinical Neuroscience.

[23]  J. Jonides,et al.  Storage and executive processes in the frontal lobes. , 1999, Science.

[24]  Dean Keith Simonton,et al.  Scientific Status of Disciplines, Individuals, and Ideas: Empirical Analyses of the Potential Impact of Theory , 2006 .

[25]  Indre V. Viskontas,et al.  Symptoms of Frontotemporal Dementia Provide Insights into Orbitofrontal Cortex Function and Social Behavior , 2007, Annals of the New York Academy of Sciences.

[26]  M. Petrides.  The Orbitofrontal Cortex: Novelty, Deviation from Expectation, and Memory , 2007, Annals of the New York Academy of Sciences.

[27]  Jonathan D. Cohen,et al.  Anterior Cingulate Conflict Monitoring and Adjustments in Control , 2004, Science.

[28]  Lisa Feldman Barrett,et al.  Neuroanatomical correlates of extraversion and neuroticism. , 2005, Cerebral cortex.

[29]  S. M. Resnick,et al.  II. Temporal patterns of longitudinal change in aging brain function , 2008, Neurobiology of Aging.

[30]  Marcellus M. Merritt,et al.  Personality Traits and Sex Differences in Emotion Recognition among African Americans and Caucasians , 2003, Annals of the New York Academy of Sciences.

[31]  T. Bouchard,et al.  Genes, environment, and personality. , 1994, Science.

[32]  T. Braver,et al.  A theory of cognitive control, aging cognition, and neuromodulation , 2002, Neuroscience & Biobehavioral Reviews.

[33]  John A. Johnson,et al.  Handbook of personality psychology. , 1997 .

[34]  Karine Sergerie,et al.  The role of the amygdala in emotional processing: A quantitative meta-analysis of functional neuroimaging studies , 2008, Neuroscience & Biobehavioral Reviews.

[35]  I. Rossman,et al.  Normal Human Aging: The Baltimore Longitudinal Study of Aging , 1986 .

[36]  L. Cahill.  Why sex matters for neuroscience , 2006, Nature Reviews Neuroscience.

[37]  Robert R. McCrae,et al.  Aesthetic Chills as a Universal Marker of Openness to Experience , 2007 .

[38]  J. Hyde,et al.  The Gender Similarities Hypothesis , 2005 .

[39]  A. Drzezga,et al.  Gender differences in brain reserve , 2007, Journal of Neurology.

[40]  A. Alavi,et al.  Sex differences in regional cerebral glucose metabolism during a resting state , 1995, Science.

[41]  N C Andreasen,et al.  Cerebral blood flow and personality: a positron emission tomography study. , 1999, The American journal of psychiatry.

[42]  J. Cohen,et al.  Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. , 2000, Science.

[43]  S. Seibert,et al.  The big five personality dimensions and entrepreneurial status: a meta-analytical review. , 2006, The Journal of applied psychology.

[44]  H. Garavan,et al.  Dissociable Executive Functions in the Dynamic Control of Behavior: Inhibition, Error Detection, and Correction , 2002, NeuroImage.

[45]  Joseph M. Andreano,et al.  Glucocorticoid Release and Memory Consolidation in Men and Women , 2006, Psychological science.