The update of prostatic ductal adenocarcinoma.

Since initially described in 1967, prostatic ductal adenocarcinoma (PDA) has engendered a series of controversies on its origin, histological features, and biological behavior. Owing to the improvement of molecular biological technique, there are some updated findings on the characteristics of PDA. In the current review, we will mainly analyze its origin, clinical manifestations, morphological features, differential diagnosis, immunophenotype and molecular genetics, with the purpose of enhancing recognition of this tumor and making a correct diagnosis and treatment choice.

[1]  B. Delahunt,et al.  Diagnostic criteria for ductal adenocarcinoma of the prostate: interobserver variability among 20 expert uropathologists , 2014, Histopathology.

[2]  C. Ng,et al.  Ductal adenocarcinoma of the prostate: a Hong Kong case series , 2014, International Urology and Nephrology.

[3]  B. Delahunt,et al.  Immunohistochemical profile of ductal adenocarcinoma of the prostate , 2014, Virchows Archiv.

[4]  T. Kalinowski,et al.  An incidentally diagnosed prostatic ductal adenocarcinoma , 2013, Central European journal of urology.

[5]  L. Egevad,et al.  Histopathological features of ductal adenocarcinoma of the prostate in 1,051 radical prostatectomy specimens , 2013, Virchows Archiv.

[6]  T. Tot,et al.  Immunohistochemical verification of ductal differentiation in prostate cancer , 2012, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[7]  P. Humphrey,et al.  Ductal adenocarcinoma of the prostate. , 2011, The Journal of urology.

[8]  T. Morgan,et al.  Ductal adenocarcinoma of the prostate: increased mortality risk and decreased serum prostate specific antigen. , 2010, The Journal of urology.

[9]  J. Epstein,et al.  Rare histological patterns of prostatic ductal adenocarcinoma , 2010, Pathology.

[10]  B. Delahunt,et al.  Any proportion of ductal adenocarcinoma in radical prostatectomy specimens predicts extraprostatic extension. , 2010, Human pathology.

[11]  J. Epstein.  An update of the Gleason grading system. , 2010, The Journal of urology.

[12]  J. Epstein.  Prostatic Ductal Adenocarcinoma: A Mini Review , 2009, Medical Principles and Practice.

[13]  P. Humphrey,et al.  Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate , 2009, Modern Pathology.

[14]  E. Platz,et al.  TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas , 2009, Modern Pathology.

[15]  S. Lang,et al.  Prostate cancer stem cells , 2009, The Journal of pathology.

[16]  B. Delahunt,et al.  Ductal adenocarcinoma of the prostate: current opinion and controversies. , 2008, Analytical and quantitative cytology and histology.

[17]  J. Epstein,et al.  High-grade Prostatic Intraepithelial Neoplasialike Ductal Adenocarcinoma of the Prostate: A Clinicopathologic Study of 28 Cases , 2008, The American journal of surgical pathology.

[18]  M. Rubin,et al.  A proposal on the identification, histologic reporting, and implications of intraductal prostatic carcinoma. , 2007, Archives of pathology & laboratory medicine.

[19]  J. Epstein,et al.  Immunohistochemical Antibody Cocktail Staining (p63/HMWCK/AMACR) of Ductal Adenocarcinoma and Gleason Pattern 4 Cribriform and Noncribriform Acinar Adenocarcinomas of the Prostate , 2007, The American journal of surgical pathology.

[20]  R. Millikan,et al.  Prostate cancer progression in the presence of undetectable or low serum prostate‐specific antigen level , 2007, Cancer.

[21]  T. H. van der Kwast,et al.  My approach to intraductal lesions of the prostate gland , 2006, Journal of Clinical Pathology.

[22]  P. Tan,et al.  Thyroid transcription factor-1 may be expressed in ductal adenocarcinoma of the prostate:a potential pitfall , 2006, Journal of Clinical Pathology.

[23]  P. Humphrey,et al.  Stratified epithelium in prostatic adenocarcinoma: a mimic of high-grade prostatic intraepithelial neoplasia , 2006, Modern Pathology.

[24]  Mahul B Amin,et al.  Update on the Gleason Grading System for Prostate Cancer: Results of an International Consensus Conference of Urologic Pathologists , 2006, Advances in anatomic pathology.

[25]  Ö. Tulunay,et al.  Prostatic ductal adenocarcinoma showing Bcl‐2 expression , 2004, International journal of urology : official journal of the Japanese Urological Association.

[26]  A. Sapino,et al.  Prostatic Duct Carcinoma with Combined Prostatic Duct Adenocarcinoma and Urothelial Carcinoma Features , 2004, International Journal of Surgical Pathology.

[27]  D. Grignon.  Unusual subtypes of prostate cancer , 2004, Modern Pathology.

[28]  P. Humphrey.  Tumors of the Prostate Gland, Seminal Vesicles, Male Urethra, and Penis , 2003 .

[29]  A. D'Amico,et al.  Neoplasms of the Prostate , 2003 .

[30]  P. Troncoso,et al.  Prostate carcinoma with testicular or penile metastases , 2002, Cancer.

[31]  P. Humphrey,et al.  The morphologic spectrum of metastatic prostatic adenocarcinoma to the lung: special emphasis on histologic features overlapping with other pulmonary neoplasms. , 2002, American journal of clinical pathology.

[32]  N. Goldstein.  Immunophenotypic characterization of 225 prostate adenocarcinomas with intermediate or high Gleason scores. , 2002, American journal of clinical pathology.

[33]  D. Bostwick,et al.  Does prostatic ductal adenocarcinoma exist? , 1999, The American journal of surgical pathology.

[34]  E. Millar,et al.  Ductal (endometrioid) adenocarcinoma of the prostate: a clinicopathological study of 16 cases , 1996, Histopathology.

[35]  P. Malone,et al.  Prostate , 1995 .

[36]  [Prostatic adenocarcinoma showing features of endometrioid and mucinous carcinomas: a case report]. , 1995, Hinyokika kiyo. Acta urologica Japonica.

[37]  N. Ordóñez,et al.  Prostatic duct adenocarcinoma with endometrioid features: immunohistochemical and electron microscopic study. , 1988, Seminars in diagnostic pathology.

[38]  J. Epstein,et al.  Adenocarcinoma of the prostate with endometrioid features. A light microscopic and immunohistochemical study of ten cases , 1986, Cancer.

[39]  D. Bostwick,et al.  Prostatic adenocarcinoma with endometrioid features: Clinical, pathologic, and ultrastructural findings , 1985, The American journal of surgical pathology.

[40]  M. Bishop,et al.  Carcinoma of the prostate of ductal origin. , 1984, British journal of urology.

[41]  G. Kopelson,et al.  Periurethral prostatic duct carcinoma. Clinical features and treatment results , 1978, Cancer.

[42]  G. Farrow,et al.  Prostatic adenocarcinoma of ductal origin , 1973, Cancer.

[43]  M. Melicow,et al.  Endometrial carcinoma of prostatic utricle (uterus masculinus) , 1967 .