Non-invasive Pain Sensor Development for Advanced Control Strategy of Anesthesia - A Conceptual Study

This paper introduces the mechanisms of pain perception in the human body in order to start the challenging task of controlling analgesia as part of general anesthesia. This research proposes a pain sensor, which measures analgesia levels. For control purpose, a prediction model is needed in order to obtain a model-based predictive control (MPC) strategy. This paper proposes to employ a compartmental fractional-order derivative model as a prediction model for the diffusion process that occurs when a drug is taken up by the human body. Simulations are preformed to investigate the effect of the fractional order on the diffusion of Propofol in the human body.

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