A new detection scheme for ultrafast 2D J-resolved spectroscopy.

Recent ultrafast techniques enable 2D NMR spectra to be obtained in a single scan. A modification of the detection scheme involved in this technique is proposed, permitting the achievement of 2D 1H J-resolved spectra in 500 ms. The detection gradient echoes are substituted by spin echoes to obtain spectra where the coupling constants are encoded along the direct nu2 domain. The use of this new J-resolved detection block after continuous phase-encoding excitation schemes is discussed in terms of resolution and sensitivity. J-resolved spectra obtained on cinnamic acid and 3-ethyl bromopropionate are presented, revealing the expected 2D J-patterns with coupling constants as small as 2 Hz.

[1]  Magnetic resonance in chemistry and biology : based on lectures at the Ampère International Summer School on Magnetic Resonance in Chemistry and Biology, Baško Polje, Yugoslavia, June 1971 , 1975 .

[2]  Philippe Pelupessy,et al.  Adiabatic single scan two-dimensional NMR spectrocopy. , 2003, Journal of the American Chemical Society.

[3]  Lucio Frydman,et al.  Principles and features of single-scan two-dimensional NMR spectroscopy. , 2003, Journal of the American Chemical Society.

[4]  R. R. Ernst,et al.  Two‐dimensional spectroscopy. Application to nuclear magnetic resonance , 1976 .

[5]  Ghost-peak suppression in ultrafast two-dimensional NMR spectroscopy. , 2003, Journal of magnetic resonance.

[6]  Lucio Frydman,et al.  Ultrafast 2D NMR spectroscopy using a continuous spatial encoding of the spin interactions. , 2004, Journal of magnetic resonance.

[7]  S. Akoka,et al.  Optimization of homonuclear 2D NMR for fast quantitative analysis: application to tropine-nortropine mixtures. , 2007, Journal of pharmaceutical and biomedical analysis.

[8]  Richard R. Ernst,et al.  Homonuclear broad band decoupling and two-dimensional J-resolved NMR spectroscopy , 1976 .

[9]  Lucio Frydman,et al.  The acquisition of multidimensional NMR spectra within a single scan , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Freeman,et al.  Resolving overlap in two‐dimensional NMR spectra: nuclear Overhauser effects in a polysaccharide , 2005, Magnetic resonance in chemistry : MRC.

[11]  L. Frydman,et al.  Ultrafast two-dimensional NMR spectroscopy using constant acquisition gradients. , 2006, The Journal of chemical physics.

[12]  P Mansfield,et al.  Spatial mapping of the chemical shift in NMR , 1983, Magnetic resonance in medicine.

[13]  A simple approach for phase‐modulated single‐scan 2D NMR spectroscopy , 2005, Magnetic resonance in chemistry : MRC.

[14]  A continuous phase-modulated approach to spatial encoding in ultrafast 2D NMR spectroscopy. , 2005, Journal of magnetic resonance.

[15]  Lucio Frydman,et al.  Spatially encoded NMR and the acquisition of 2D magnetic resonance images within a single scan. , 2005, Journal of magnetic resonance.