Dynamic epidermal cooling in conjunction with laser‐induced photothermolysis of port wine stain blood vessels

When a cryogen spurt is applied to the skin surface for an appropriately short period of time (on the order of tens of milliseconds), the spatial distribution of cooling remains localized in the normal overlying epidermis, while leaving the temperature of the deeper port wine stain (PWS) blood vessels unchanged. Furthermore, cooling continues after pulsed laser exposure as cryogen remaining on the surface evaporates and removes heat deposited by light absorption in epidermal melanin. An additional advantage of dynamic cooling is a reduction in the level of pain and discomfort associated with flashlamp‐pumped pulsed dye laser therapy of PWS. Preliminary clinical studies and supporting theoretical calculations demonstrate the feasibility of selective epidermal cooling while achieving photothermolysis of blood vessels during pulsed laser treatment of PWS. © 1996 Wiley‐Liss, Inc.

[1]  J M Garden,et al.  The treatment of port-wine stains by the pulsed dye laser. Analysis of pulse duration and long-term therapy. , 1988, Archives of dermatology.

[2]  R. Geronemus,et al.  Treatment of port-wine stains during childhood with the flashlamp-pumped pulsed dye laser. , 1990, Journal of the American Academy of Dermatology.

[3]  B. Gilchrest,et al.  Treatment of children with port-wine stains using the flashlamp-pulsed tunable dye laser. , 1989, The New England journal of medicine.

[4]  Thomas E. Milner,et al.  Space-dependent temperature increase in human skin subsurface chromophores immediately following pulsed laser exposure , 1996, European Conference on Biomedical Optics.

[5]  R G Geronemus,et al.  Capillary hemangiomas and treatment with the flash lamp-pumped pulsed dye laser. , 1991, Archives of dermatology.

[6]  L. Manzer,et al.  The CFC-Ozone Issue: Progress on the Development of Alternatives to CFCs , 1990, Science.

[7]  Steven L. Jacques,et al.  Determination of thermal and physical properties of port-wine stain lesions using pulsed photothermal radiometry , 1992, Photonics West - Lasers and Applications in Science and Engineering.

[8]  B. S. Tanenbaum,et al.  Selective cooling of biological tissues: application for thermally mediated therapeutic procedures. , 1995, Physics in medicine and biology.

[9]  C Chess,et al.  Cool laser optics treatment of large telangiectasia of the lower extremities. , 1993, The Journal of dermatologic surgery and oncology.

[10]  S L Jacques,et al.  Pulsed photothermal radiometry of port-wine-stain lesions. , 1993, Applied optics.

[11]  B. S. Tanenbaum,et al.  Depth profiling of laser-heated chromophores in biological tissues by pulsed photothermal radiometry. , 1995, Journal of the Optical Society of America. A, Optics, image science, and vision.

[12]  J. Stuart Nelson,et al.  Clinical Management of Port-Wine Stain in Infants and Young Children Using the Flashlamp-Pulsed Dye Laser , 1990, Clinical pediatrics.

[13]  J. C. Jaeger,et al.  Conduction of Heat in Solids , 1952 .

[14]  F. Duck.  Physical properties of tissue , 1990 .

[15]  B. Dréno,et al.  The benefit of chilling in argon-laser treatment of port-wine stains. , 1985, Plastic and reconstructive surgery.

[16]  R.R. Anderson,et al.  Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. , 1983, Science.

[17]  R. Geronemus,et al.  Flashlamp-pumped pulsed dye laser for port-wine stains in infancy: earlier versus later treatment. , 1991, Journal of the American Academy of Dermatology.

[18]  J M Noe,et al.  Chilling Port Wine Stains Improves the Response to Argon Laser Therapy , 1982, Plastic and reconstructive surgery.

[19]  B. S. Tanenbaum,et al.  Dynamic epidermal cooling during pulsed laser treatment of port-wine stain. A new methodology with preliminary clinical evaluation. , 1995, Archives of dermatology.