In this paper, we study the problem of detecting early signs of Parkinson's disease during an indirect human-computer interaction via a computer mouse activated by a user. The experimental setup provides a signal determined by the screen pointer position. An appropriate choice of segments in the cursor position raw data provides a filtered signal from which a number of quantifiable criteria can be obtained. These dynamical features are derived based on control theory methods. Thanks to these indicators, a subsequent analysis allows the detection of users with tremor. Real-life data from patients with Parkinson's and healthy controls are used to illustrate our detection method.