Relaxation and osmotic-induced slow strain mapping in biological tissues by optical coherence elastography

Imaging of slow deformations in biological tissues may contribute to study and reveal many complex processes, such as fluid flow, mechanical stress growth and relaxation, formation of interstitial pores caused by application of external force. Here the new method of strain mapping based on analysis of complex-valued OCT signal for real-time cartilage visualization is presented. Cartilaginous tissue is modified with laser radiation, immersion agent glycerol and on air drying. The evolution of strain caused by the modifying effects is analyzed. For the non-equilibrium diffusion regime, it was shown that the tissue experiences intensive alternate-sign strain with the amplitudes up to 0.4. The extensive dehydration within 1 mm thickness of the tissue and pronounced subsurface swelling are detected. The strains caused by osmotically-induced and on air dehydration are compared.

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