Topography of mobility and complexity parameters of the EEG in Alzheimer's Disease

Mobility and complexity, Hjorth's parameters of the electroencephalogram (EEG), were calculated in 16 electrodes in a group of 14 patients with probable Alzheimer's disease (AD) and 14 healthy controls. Mobility was decreased in the AD group, differences reaching high levels of significance over all the electrodes. Complexity was increased significantly in the AD group only in five electrodes. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for mobility at each electrode, considering only those AD patients with the lowest cognitive impairment. Sensitivity and negative predictive value were 100% at all the electrodes. Specificity and positive predictive value at several electrodes reached highly acceptable proportions, such as 71% or more for the former, and 64% or more for the latter. Implications of mobility in the early diagnosis of AD are discussed.

[1]  B. Hjorth.  EEG analysis based on time domain properties. , 1970, Electroencephalography and clinical neurophysiology.

[2]  B. Hjorth.  The physical significance of time domain descriptors in EEG analysis. , 1973, Electroencephalography and clinical neurophysiology.

[3]  Frank H. Duffy,et al.  Topographic Mapping of Brain Electrical Activity , 1986 .

[4]  Gwenn S. Smith,et al.  Gray‐matter degeneration in presenile alzheimer's disease , 1989, Annals of neurology.

[5]  B. L. Beattie,et al.  Positron emission tomography in patients with clinically diagnosed Alzheimer's disease. , 1986, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[6]  Pronk Ra,et al.  Automatic recognition of abnormal EEG activity during open heart and carotid surgery. , 1982 .

[7]  D L Price,et al.  Alzheimer's disease: a disorder of cortical cholinergic innervation. , 1983, Science.

[8]  J. Smyth,et al.  Progress in Clinical and Biological Research , 1979 .

[9]  F. Schmitt,et al.  Assessing Utility of Single Photon Emission Computed Tomography (SPECT) Scan in Alzheimer Disease: Correlation with Cognitive Severity , 1990, Alzheimer disease and associated disorders.

[10]  Bo Hjorth,et al.  9 – Physical Aspects of EEG Data as a Basis for Topographic Mapping , 1986 .

[11]  D. Sackett,et al.  The Ends of Human Life: Medical Ethics in a Liberal Polity , 1992, Annals of Internal Medicine.

[12]  Mann Dm.  The site and nature of the primary lesions in Alzheimer's disease. , 1989 .

[13]  F. Duffy,et al.  Clinical Electroencephalography and Topographic Brain Mapping , 1989 .

[14]  A Z Snyder,et al.  Replication of a study of frequency analysis of the resting awake EEG in mild probable Alzheimer's disease. , 1990, Electroencephalography and clinical neurophysiology.

[15]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[16]  J. Jolles.  Cognitive, emotional and behavioral dysfunctions in aging and dementia. , 1986, Progress in brain research.

[17]  THE FUTURE OF ALZHEIMER'S DISEASE RESEARCH , 1989, Progress in clinical and biological research.

[18]  Frank H. Duffy,et al.  Clinical Electroencephalography and Topographic Brain Mapping: Technology and Practice , 1989 .

[19]  T. Powell,et al.  A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[20]  D. Neary,et al.  THE PROGRESSION OF THE PATHOLOGICAL CHANGES OF ALZHEIMER'S DISEASE IN FRONTAL AND TEMPORAL NEOCORTEX EXAMINED BOTH AT BIOPSY AND AT AUTOPSY , 1988, Neuropathology and applied neurobiology.

[21]  B. L. Beattie,et al.  18Fluorodeoxyglucose Positron Emission Tomography Studies in Presumed Alzheimer Cases, Including 13 Serial Scans , 1990, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[22]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[23]  W. Jagust,et al.  Longitudinal studies of regional cerebral metabolism in Alzheimer's disease , 1988, Neurology.

[24]  M. Roth,et al.  The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects , 1968, British Journal of Psychiatry.

[25]  S. DeKosky,et al.  Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity , 1990, Annals of neurology.