Unveiling the Zoonotic Significance of Toxocariasis in Humans: The Role of Toxocara canis

Toxocariasis is a zoonotic disease caused by the parasite Toxocara canis, with significant effects on human health. This article provided a comprehensive overview of the importance of complications of Toxocara canis infection. The introduction highlighted the relevance of zoonotic diseases and introduced toxocariasis as a specific example. The subsequent sections delved into toxocariasis, covering its transmission, lifecycle, host specificity, and primary sources of human infection. The epidemiology section presented the global prevalence and distribution of toxocariasis at 11.1% (95% CI: 10.6–11.7%), emphasizing high-risk groups and geographical factors contributing to illness. Detailed information was provided regarding the clinical manifestations of toxocariasis, including variations in disease severity and potential complications. Symptoms of visceral toxocariasis include fever, fatigue, coughing, wheezing, or abdominal pain. The diagnostic methods include laboratory methods (serological testing and western blot) and molecular techniques (PCR), and clinical methods (chest X-ray and CT scan). The prevention and control section outlined strategies for prevention, highlighting the significance of public health measures and awareness campaigns. The One Health approach has recognized the interconnections between human, animal, and environmental health. It has highlighted the necessity of cooperative actions to prevent the spread of diseases that can be transmitted between animals and humans. Future directions need to highlight ongoing research and advancements, including improved diagnostic tools, targeted therapies, risk assessment, and international collaboration. The conclusion reinforces the importance of understanding and addressing Toxocara canis infection on human health. Adopting a One Health approach and implementing effective prevention, diagnosis, and treatment strategies can reduce the burden of toxocariasis, leading to improved health outcomes for humans and animals.

[1]  H. Borji,et al.  Anti-Tumor Effect of Protoscolex Hydatid Cyst Somatic Antigen on Inhibition Cell Growth of K562 , 2023, Acta Parasitologica.

[2]  H. Borji,et al.  Trichinella spiralis as a Potential Antitumor Agent: An Update , 2023, World's Veterinary Journal.

[3]  A. Khakshoor,et al.  The Innate Immunity Defense against Gastrointestinal Nematodes: Vaccine Development , 2022, Farm Animal Health and Nutrition.

[4]  H. Portugaliza,et al.  Prevalence of Toxocara canis infection in dogs and Toxocara egg environmental contamination in Baybay City, Leyte, Philippines , 2022, Journal of Parasitic Diseases.

[5]  S. Islam,et al.  Insights to helminth infections in food and companion animals in Bangladesh: Occurrence and risk profiling , 2022, Parasite epidemiology and control.

[6]  N. Alcântara-Neves,et al.  Protective response mediated by immunization with recombinant proteins in a murine model of toxocariasis and canine infection by Toxocara canis. , 2022, Vaccine.

[7]  C. Holland,et al.  Toxocara: time to let cati 'out of the bag'. , 2022, Trends in parasitology.

[8]  P. Fields,et al.  The epidemiology and control of Toxocara canis in puppies , 2021, Parasite epidemiology and control.

[9]  P. Daszak,et al.  Wild animal and zoonotic disease risk management and regulation in China: Examining gaps and One Health opportunities in scope, mandates, and monitoring systems , 2021, One Health.

[10]  R. Traub,et al.  Canine gastrointestinal parasites as a potential source of zoonotic infections in Nigeria: A nationwide survey. , 2021, Preventive veterinary medicine.

[11]  D. Jianu,et al.  Clinical spectrum of symptoms in cerebral Toxocariasis (Review). , 2021, Experimental and therapeutic medicine.

[12]  D. Bowman Ascaris and Toxocara as foodborne and waterborne pathogens. , 2020, Research in veterinary science.

[13]  D. A. Jaramillo-Hernández,et al.  Toxocariasis y vacunación para Toxocara: una revisión sistemática , 2020 .

[14]  D. Pasotto,et al.  Surveillance of Zoonotic Parasites in Animals Involved in Animal-Assisted Interventions (AAIs) , 2020, International journal of environmental research and public health.

[15]  S. Aksoy,et al.  Vector-borne Zoonotic Diseases in Turkey: Rising Threats on Public Health. , 2020, Turkiye parazitolojii dergisi.

[16]  P. Hotez,et al.  Toxocara species environmental contamination of public spaces in New York City , 2020, PLoS neglected tropical diseases.

[17]  Ioannis N. Mavridis,et al.  Toxocariasis of the Nervous System , 2020, Acta Parasitologica.

[18]  H. Hosseini,et al.  Prevalence of Toxocara and Toxascaris infection among human and animals in Iran with meta-analysis approach , 2020, BMC Infectious Diseases.

[19]  S. Little,et al.  Prevalence of intestinal parasites in fecal samples and estimation of parasite contamination from dog parks in central Oklahoma. , 2020, Veterinary parasitology, regional studies and reports.

[20]  P. Hotez,et al.  Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis , 2019, PLoS neglected tropical diseases.

[21]  J. Novák,et al.  Seroprevalence of Larval Toxocarosis in the Czech Republic , 2019, Acta Parasitologica.

[22]  Bill C. H. Chang,et al.  Human toxocariasis - A look at a neglected disease through an epidemiological 'prism'. , 2019, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

[23]  D. Mccrann,et al.  Coproantigen Detection Augments Diagnosis of Common Nematode Infections in Dogs. , 2019, Topics in companion animal medicine.

[24]  A. Rostami,et al.  Toxocara eggs in public places worldwide - A systematic review and meta-analysis. , 2018, Environmental pollution.

[25]  A. Tsakris,et al.  Soil contamination by Toxocara canis and human seroprevalence in the Attica region, Greece. , 2018, Germs.

[26]  I. Abou-El-Naga [Developmental stages and viability of Toxocara canis eggs outside the host]. , 2018, Biomedica : revista del Instituto Nacional de Salud.

[27]  Guo-Hua Liu,et al.  Toxocariasis: a silent threat with a progressive public health impact , 2018, Infectious Diseases of Poverty.

[28]  K. Pethiyagoda,et al.  Frequency of Toxocariasis among Patients Clinically Suspected to Have Visceral Toxocariasis: A Retrospective Descriptive Study in Sri Lanka , 2017, Journal of parasitology research.

[29]  Anunobi Toochukwu Joy,et al.  Toxocariasis and Public Health: An Epidemiological Review , 2017 .

[30]  M. Freeman,et al.  Exposure to Animal Feces and Human Health: A Systematic Review and Proposed Research Priorities , 2017, Environmental science & technology.

[31]  Ting-Wu Chuang,et al.  Seroepidemiological study and associated risk factors of Toxocara canis infection among preschool children in Osun State, Nigeria. , 2017, Acta tropica.

[32]  Thomas A. Beltran,et al.  Prevalence of Toxocara species infection in the U.S.: Results from the National Health and Nutrition Examination Survey, 2011-2014 , 2017, PLoS neglected tropical diseases.

[33]  R. Callaby,et al.  Free‐Roaming Dogs in Nepal: Demographics, Health and Public Knowledge, Attitudes and Practices , 2017, Zoonoses and public health.

[34]  A. Drzewiecka,et al.  Distribution and dynamics of soil contamination with Toxocara canis and Toxocara cati eggs in Poland and prevention measures proposed after 20 years of study. , 2017, Veterinary parasitology.

[35]  B. S. Kim,et al.  Clinical characteristics and progression of liver abscess caused by toxocara. , 2016, World journal of hepatology.

[36]  S. Etewa,et al.  Geohelminths distribution as affected by soil properties, physicochemical factors and climate in Sharkyia governorate Egypt , 2016, Journal of Parasitic Diseases.

[37]  W. van Pelt,et al.  Seroepidemiology of human Toxocara and Ascaris infections in the Netherlands , 2016, Parasitology Research.

[38]  M. Zibaei,et al.  Evaluation of Toxocara cati Excretory–Secretory Larval Antigens in Serodiagnosis of Human Toxocariasis , 2016, Journal of clinical laboratory analysis.

[39]  A. Neumayr,et al.  Toxocariasis-associated cardiac diseases--A systematic review of the literature. , 2016, Acta tropica.

[40]  Papa Kofi Amissah-Reynolds,et al.  Prevalence of Helminths in Dogs and Owners' Awareness of Zoonotic Diseases in Mampong, Ashanti, Ghana , 2016, Journal of parasitology research.

[41]  J. Gill,et al.  Larva migrans in India: veterinary and public health perspectives , 2015, Journal of Parasitic Diseases.

[42]  M. Awadallah,et al.  Zoonotic enteric parasites transmitted from dogs in Egypt with special concern to Toxocara canis infection , 2015, Veterinary world.

[43]  Ting-Wu Chuang,et al.  Seroprevalence, disease awareness, and risk factors for Toxocara canis infection among primary schoolchildren in Makoko, an urban slum community in Nigeria. , 2015, Acta tropica.

[44]  D. Correa,et al.  Successful capture of Toxocara canis larva antigens from human serum samples , 2015, Parasites & Vectors.

[45]  A. Akçay,et al.  Role of cat and dog faeces in the contamination of sand playgrounds in public parks by Toxocara spp. , 2020, Medycyna Weterynaryjna.

[46]  B. Kiziewicz,et al.  Environmental contamination with Toxocara eggs and seroprevalence of toxocariasis in children of northeastern Poland , 2015, Parasitology Research.