An EPID-based system for gantry-resolved MLC quality assurance for VMAT.

Multileaf collimator (MLC) positions should be precisely and independently measured as a function of gantry angle as part of a comprehensive quality assurance (QA) program for volumetric-modulated arc therapy (VMAT). It is also ideal that such a QA program has the ability to relate MLC positional accuracy to patient-specific dosimetry in order to determine the clinical significance of any detected MLC errors. In this work we propose a method to verify individual MLC trajectories during VMAT deliveries for use as a routine linear accelerator QA tool. We also extend this method to reconstruct the 3D patient dose in the treatment planning system based on the measured MLC trajectories and the original DICOM plan file. The method relies on extracting MLC positions from EPID images acquired at 8.41 fps during clinical VMAT deliveries. A gantry angle is automatically tagged to each image in order to obtain the MLC trajectories as a function of gantry angle. This analysis was performed for six clinical VMAT plans acquired at monthly intervals for three months. The measured trajectories for each delivery were compared to the MLC positions from the DICOM plan file. The maximum mean error detected was 0.07 mm and a maximum root-mean-square error was 0.8 mm for any leaf of any delivery. The sensitivity of this system was characterized by introducing random and systematic MLC errors into the test plans. It was demonstrated that the system is capable of detecting random and systematic errors on the range of 1-2 mm and single leaf calibration errors of 0.5 mm. The methodology developed in the work has potential to be used for efficient routine linear accelerator MLC QA and pretreatment patient-specific QA and has the ability to relate measured MLC positional errors to 3D dosimetric errors within a patient volume. PACS number(s): 87.55.Qr.

[1]  Pejman Rowshanfarzad,et al.  Detection and correction for EPID and gantry sag during arc delivery using cine EPID imaging. , 2012, Medical physics.

[2]  David Sjostrom,et al.  Implementing RapidArc into clinical routine: a comprehensive program from machine QA to TPS validation and patient QA. , 2011, Medical physics.

[3]  T. Losasso,et al.  IMRT delivery performance with a varian multileaf collimator. , 2008, International journal of radiation oncology, biology, physics.

[4]  Karl Otto,et al.  Volumetric modulated arc therapy: IMRT in a single gantry arc. , 2007, Medical physics.

[5]  R I MacKay,et al.  Use of an amorphous silicon electronic portal imaging device for multileaf collimator quality control and calibration , 2005, Physics in medicine and biology.

[6]  Pejman Rowshanfarzad,et al.  EPID-based verification of the MLC performance for dynamic IMRT and VMAT. , 2012, Medical physics.

[7]  T LoSasso,et al.  Testing of dynamic multileaf collimation. , 1996, Medical physics.

[8]  E. Mok,et al.  Dose reconstruction for volumetric modulated arc therapy (VMAT) using cone-beam CT and dynamic log files , 2010, Physics in medicine and biology.

[9]  David A Jaffray,et al.  Intensity-modulated arc therapy with dynamic multileaf collimation : an alternative to tomotherapy , 2002 .

[10]  Alejandra Rangel,et al.  Tolerances on MLC leaf position accuracy for IMRT delivery with a dynamic MLC. , 2009, Medical physics.

[11]  C. Ling,et al.  Commissioning and quality assurance of RapidArc radiotherapy delivery system. , 2008, International journal of radiation oncology, biology, physics.

[12]  Benedick A Fraass,et al.  Incorporation of realistic delivery limitations into dynamic MLC treatment delivery. , 2002, Medical physics.

[13]  James F Dempsey,et al.  Validation of dynamic MLC-controller log files using a two-dimensional diode array. , 2003, Medical physics.

[14]  Ravikumar Manickam,et al.  Consistency and reproducibility of the VMAT plan delivery using three independent validation methods , 2010, Journal of applied clinical medical physics.

[15]  James F Dempsey,et al.  Verification of step-and-shoot IMRT delivery using a fast video-based electronic portal imaging device. , 2004, Medical physics.

[16]  M C Kirby,et al.  Verification of dynamic multileaf collimation using an electronic portal imaging device. , 2000, Physics in medicine and biology.

[17]  Zdenka Kuncic,et al.  A system for EPID-based real-time treatment delivery verification during dynamic IMRT treatment. , 2013, Medical physics.

[18]  P. C. Williams,et al.  Requirements for leaf position accuracy for dynamic multileaf collimation. , 2000, Physics in medicine and biology.

[19]  F. Lohr,et al.  Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer. , 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[20]  Pejman Rowshanfarzad,et al.  An independent system for real-time dynamic multileaf collimation trajectory verification using EPID. , 2014, Physics in medicine and biology.

[21]  K. Bush,et al.  Clinical significance of multi-leaf collimator positional errors for volumetric modulated arc therapy. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[22]  Carlos Daniel Venencia,et al.  Commissioning and quality assurance for intensity‐modulated radiotherapy with dynamic multileaf collimator: Experience of the Pontificia Universidad Católica de Chile , 2004, Journal of applied clinical medical physics.

[23]  Peter B. Greer,et al.  Development of EPID-based Real time Dose Verification for Dynamic IMRT , 2011 .

[24]  L Kumaraswamy,et al.  Using an EPID for patient-specific VMAT quality assurance. , 2011, Medical physics.

[25]  Jie Yang,et al.  Monte Carlo based IMRT dose verification using MLC log files and R/V outputs. , 2006, Medical physics.

[26]  E. Schreibmann,et al.  Patient-specific quality assurance method for VMAT treatment delivery. , 2009, Medical physics.

[27]  Peter B. Greer,et al.  Poster — Thur Eve — 51: An Investigation of Geometry Issues for EPID Dosimetry during Rotational IMRT , 2010 .

[28]  Steve B. Jiang,et al.  Dependence of fluence errors in dynamic IMRT on leaf-positional errors varying with time and leaf number. , 2003, Medical physics.

[29]  Lei Xing,et al.  Dose verification for respiratory-gated volumetric modulated arc therapy. , 2011, Physics in medicine and biology.

[30]  Pejman Rowshanfarzad,et al.  Gantry-angle resolved VMAT pretreatment verification using EPID image prediction. , 2013, Medical physics.

[31]  Peter B. Greer,et al.  An investigation of gantry angle data accuracy for cine‐mode EPID images acquired during arc IMRT , 2014, Journal of applied clinical medical physics.

[32]  Clive Baldock,et al.  An experimental investigation into the radiation field offset of a dynamic multileaf collimator , 2006, Physics in medicine and biology.

[33]  M K Jørgensen,et al.  Tolerance levels of EPID-based quality control for volumetric modulated arc therapy. , 2011, Medical physics.

[34]  Y. Nishimura,et al.  The effect of gantry and collimator angles on leaf limited velocity and position in dynamic multileaf collimator intensity-modulated radiation therapy. , 2010, Physics in medicine and biology.

[35]  Jan-Jakob Sonke,et al.  Leaf trajectory verification during dynamic intensity modulated radiotherapy using an amorphous silicon flat panel imager. , 2004, Medical physics.

[36]  A Agnew,et al.  Monitoring daily MLC positional errors using trajectory log files and EPID measurements for IMRT and VMAT deliveries , 2014, Physics in medicine and biology.

[37]  Rogelio Díaz Moreno,et al.  A method to enhance spatial resolution of a 2D ion chamber array for quality control of MLC , 2011, Journal of applied clinical medical physics.

[38]  J. Dempsey,et al.  An extensive log-file analysis of step-and-shoot intensity modulated radiation therapy segment delivery errors. , 2004, Medical physics.

[39]  F Ballester,et al.  QA of dynamic MLC based on EPID portal dosimetry. , 2012, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[40]  Maarten L P Dirkx,et al.  Fast, daily linac verification for segmented IMRT using electronic portal imaging. , 2006, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[41]  Alejandra Rangel,et al.  The sensitivity of patient specific IMRT QC to systematic MLC leaf bank offset errors. , 2010, Medical physics.

[42]  J Eduardo Villarreal-Barajas,et al.  On the use of the MLC dosimetric leaf gap as a quality control tool for accurate dynamic IMRT delivery. , 2011, Medical physics.

[43]  Maarten L P Dirkx,et al.  Fast and accurate leaf verification for dynamic multileaf collimation using an electronic portal imaging device. , 2002, Medical physics.

[44]  L. Xing,et al.  Retrospective IMRT dose reconstruction based on cone-beam CT and MLC log-file. , 2008, International journal of radiation oncology, biology, physics.