Therapeutic intervention and signaling.
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[1] L. Peso,et al. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.
[2] B. Hemmings. Update: PtdIns(3,4,5)P3 Gets Its Message Across , 1997, Science.
[3] F. McCormick,et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. , 1997, Science.
[4] G. Panayotou,et al. Phosphoinositide 3-kinases: a conserved family of signal transducers. , 1997, Trends in biochemical sciences.
[5] Monia Bp. First- and second-generation antisense inhibitors targeted to human c-raf kinase: in vitro and in vivo studies. , 1997 .
[6] P. Casey,et al. Farnesyltransferase Inhibitors Alter the Prenylation and Growth-stimulating Function of RhoB* , 1997, The Journal of Biological Chemistry.
[7] Guido Kroemer,et al. The proto-oncogene Bcl-2 and its role in regulating apoptosis , 1997, Nature Medicine.
[8] M. Lewis,et al. Direct Demonstration of Geranylgeranylation and Farnesylation of Ki-Ras in Vivo * , 1997, The Journal of Biological Chemistry.
[9] A. Ganser,et al. Specific Hammerhead Ribozyme-mediated Cleavage of Mutant N-ras mRNA in Vitro and ex Vivo , 1997, The Journal of Biological Chemistry.
[10] W. R. Bishop,et al. K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors* , 1997, The Journal of Biological Chemistry.
[11] P. Warne,et al. Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras , 1997, Cell.
[12] C. Der,et al. The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation* , 1997, The Journal of Biological Chemistry.
[13] W. R. Bishop,et al. Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I* , 1997, The Journal of Biological Chemistry.
[14] P. Cohen,et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.
[15] J. Rine,et al. Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis , 1997, Science.
[16] P. Casey,et al. Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution , 1997, Science.
[17] J. Zweier,et al. Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts , 1997, Science.
[18] M. Kawada,et al. Inhibition of anchorage-independent growth of ras-transformed cells on polyHEMA surface by antisense oligodeoxynucleotides directed against K-ras. , 1997, Biochemical and biophysical research communications.
[19] Lewis C Cantley,et al. PI3K: Downstream AKTion Blocks Apoptosis , 1997, Cell.
[20] David R. Kaplan,et al. Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate , 1997, Science.
[21] David R. Kaplan,et al. Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt , 1997, Science.
[22] E. Querfurth,et al. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. , 1996, The EMBO journal.
[23] M. Wigler,et al. Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation , 1996, Molecular and cellular biology.
[24] Doriano Fabbro,et al. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase , 1996, Nature Medicine.
[25] F. McCormick,et al. A role for Rho in Ras transformation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[26] B. Burgering,et al. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.
[27] A. Kral,et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice , 1995, Nature Medicine.
[28] F. McCormick,et al. An essential role for Rac in Ras transformation , 1995, Nature.
[29] J. Goldstein,et al. Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro(*) , 1995, The Journal of Biological Chemistry.
[30] M. Wigler,et al. Multiple ras functions can contribute to mammalian cell transformation , 1995, Cell.
[31] Michael J. Fry,et al. Phosphatidylinositol-3-OH kinase direct target of Ras , 1994, Nature.
[32] N. Kohl,et al. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic , 1994, Cell.
[33] A. Levinson,et al. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. , 1993, Science.
[34] R L Smith,et al. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. , 1993, Science.
[35] C. Der,et al. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[36] C. Der,et al. Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein , 1992, Molecular and cellular biology.
[37] J. L. Bos,et al. ras oncogenes in human cancer: a review. , 1989, Cancer research.
[38] D. Lowy,et al. Function and regulation of ras. , 1993, Annual review of biochemistry.
[39] V. Devita,et al. Cancer : Principles and Practice of Oncology , 1982 .