Impact of Excipient Interactions on Solid Dosage Form Stability

[1]  Feng Qian,et al.  Degradation kinetics and mechanism of an oxadiazole derivative, design of a stable drug product for BMS-708163, a γ-secretase inhibitor drug candidate. , 2012, Journal of pharmaceutical sciences.

[2]  A. Narang,et al.  Formation of reactive impurities in aqueous and neat polyethylene glycol 400 and effects of antioxidants and oxidation inducers. , 2012, Journal of pharmaceutical sciences.

[3]  Leonardo M. B. Ferreira,et al.  A discriminating dissolution method for glimepiride polymorphs. , 2012, Journal of pharmaceutical sciences.

[4]  B. Macdonald,et al.  Relative humidity hysteresis in solid-state chemical reactivity: a pharmaceutical case study. , 2012, Journal of pharmaceutical sciences.

[5]  P. Timmins,et al.  Physical stability and recrystallization kinetics of amorphous ibipinabant drug product by fourier transform raman spectroscopy. , 2011, Journal of pharmaceutical sciences.

[6]  Ajit S. Narang,et al.  Reactive Impurities in Excipients: Profiling, Identification and Mitigation of Drug–Excipient Incompatibility , 2011, AAPS PharmSciTech.

[7]  W. Lib,et al.  Performance qualification of a new hypromellose capsule: Part II. Disintegration and dissolution comparison between two types of hypromellose capsules. , 2011, International journal of pharmaceutics.

[8]  G. Stephenson,et al.  Physical stability of salts of weak bases in the solid-state. , 2011, Journal of pharmaceutical sciences.

[9]  F. Lagrange.  Developing solid oral dosage forms: pharmaceutical theory and practice, Y. Qiu, Y. Chen, G.G.Z. Zhang, L. Liu, W. Porter. Elsevier (2009). 978 pp., 155 €, ISBN: 978-0-444-53242-8 , 2010 .

[10]  S. Bharate,et al.  Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review , 2010 .

[11]  C. Cornett,et al.  Reaction between drug substances and pharmaceutical excipients: formation of esters between cetirizine and polyols. , 2010, Journal of pharmaceutical and biomedical analysis.

[12]  B. Macdonald,et al.  Package selection for moisture protection for solid, oral drug products. , 2010, Journal of pharmaceutical sciences.

[13]  Divyakant Desai,et al.  Lubrication in tablet formulations. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[14]  H. Benameur,et al.  Performance qualification of a new hypromellose capsule: part I. Comparative evaluation of physical, mechanical and processability quality attributes of Vcaps Plus, Quali-V and gelatin capsules. , 2010, International journal of pharmaceutics.

[15]  M. Roberts,et al.  Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[16]  V. Rao,et al.  Role of excipients on N-oxide raloxifene generation from raloxifene-excipients binary mixtures. , 2009, Chemical & pharmaceutical bulletin.

[17]  K. Raghavan,et al.  Understanding drug-excipient compatibility: Oxidation of compound A in a solid dosage form , 2009, Pharmaceutical development and technology.

[18]  Lynne S. Taylor,et al.  Role of Salt and Excipient Properties on Disproportionation in the Solid-State , 2009, Pharmaceutical Research.

[19]  M. Roberts,et al.  Assessment of Feasibility of Maillard Reaction between Baclofen and Lactose by Liquid Chromatography and Tandem Mass Spectrometry, Application to Pre Formulation Studies , 2009, AAPS PharmSciTech.

[20]  Shagufta Khan,et al.  Formulation design of ranitidine hydrochloride to reduce its moisture absorption characteristics. , 2009, PDA journal of pharmaceutical science and technology.

[21]  S. Hansen,et al.  Reaction between drug substances and pharmaceutical excipients: formation of citric acid esters and amides of carvedilol in the solid state. , 2009, Journal of pharmaceutical and biomedical analysis.

[22]  Simona Bohanec,et al.  Predicting drug hydrolysis based on moisture uptake in various packaging designs. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[23]  D. P. Santana,et al.  Application of thermal analysis in study of binary mixtures with metformin , 2008 .

[24]  Robert J. Timpano,et al.  N-methylation and N-formylation of a secondary amine drug (varenicline) in an osmotic tablet. , 2008, Journal of pharmaceutical sciences.

[25]  Chin-San Wu,et al.  The effect of crosslinker structure upon the rate of hydroperoxide formation in dried, crosslinked poly(vinylpyrrolidone) , 2008 .

[26]  K. Ray,et al.  Identification and Control of a Degradation Product in Avapro™ Film-Coated Tablet: Low Dose Formulation , 2008, Pharmaceutical development and technology.

[27]  D. Desai,et al.  Stability of low concentrations of guanine-based antivirals in sucrose or maltitol solutions. , 2007, International journal of pharmaceutics.

[28]  Abu T M Serajuddin,et al.  Stabilization of the maleate salt of a basic drug by adjustment of microenvironmental pH in solid dosage form. , 2007, International journal of pharmaceutics.

[29]  R. Mahato.  Pharmaceutical Dosage Forms and Drug Delivery , 2007 .

[30]  S. Badawy,et al.  Microenvironmental pH modulation in solid dosage forms. , 2007, Journal of pharmaceutical sciences.

[31]  J. Tantry,et al.  Processing-induced phase transitions of theophylline--implications on the dissolution of theophylline tablets. , 2007, Journal of pharmaceutical sciences.

[32]  M. Peterson,et al.  Hydrates and Solid-State Reactivity: A Survey of β-Lactam Antibiotics , 2007 .

[33]  D. Evans,et al.  A scintigraphic investigation of the disintegration behaviour of capsules in fasting subjects: a comparison of hypromellose capsules containing carrageenan as a gelling agent and standard gelatin capsules. , 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[34]  S. Mutalik,et al.  Preparation,In vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac , 2007, Archives of pharmacal research.

[35]  E. Nelson,et al.  Degradation of vitamin D3 in a stressed formulation: the identification of esters of vitamin D3 formed by a transesterification with triglycerides. , 2007, Journal of pharmaceutical and biomedical analysis.

[36]  T. Chan,et al.  Major degradation product identified in several pharmaceutical formulations against the common cold. , 2006, Analytical chemistry.

[37]  D. Kalonia,et al.  Removal of peroxides in polyethylene glycols by vacuum drying: Implications in the stability of biotech and pharmaceutical formulations , 2006, AAPS PharmSciTech.

[38]  Pengzu Zhou,et al.  Simultaneous determination of formic acid and formaldehyde in pharmaceutical excipients using headspace GC/MS. , 2006, Journal of pharmaceutical and biomedical analysis.

[39]  S. Badawy,et al.  Formulation of Solid Dosage Forms to Overcome Gastric pH Interaction of the Factor Xa Inhibitor, BMS-561389 , 2006, Pharmaceutical Research.

[40]  Ammar Khawam,et al.  Basics and applications of solid-state kinetics: a pharmaceutical perspective. , 2006, Journal of pharmaceutical sciences.

[41]  S. Puttipipatkhachorn,et al.  The Influence of Drug-Excipient and Drug-Polymer Interactions on Butt Adhesive Strength of Ranitidine Hydrochloride Film-Coated Tablets , 2006, Drug development and industrial pharmacy.

[42]  W. Cao,et al.  Effect of milling and compression on the solid-state Maillard reaction. , 2005, Journal of pharmaceutical sciences.

[43]  Jukka Rantanen,et al.  Excipient selection can significantly affect solid-state phase transformation in formulation during wet granulation , 2005, AAPS PharmSciTech.

[44]  Margaret S. Landis,et al.  Solid-state excipient compatibility testing , 2005 .

[45]  B. Stanisz,et al.  The influence of pharmaceutical excipients on quinapril hydrochloride stability. , 2005, Acta poloniae pharmaceutica.

[46]  Ammar Khawam,et al.  Complementary use of model-free and modelistic methods in the analysis of solid-state kinetics. , 2005, The journal of physical chemistry. B.

[47]  R. Adami,et al.  Accelerated aging: prediction of chemical stability of pharmaceuticals. , 2005, International journal of pharmaceutics.

[48]  Martin Kuentz,et al.  Drug-Excipient Compatibility Testing Using a High-Throughput Approach and Statistical Design , 2005, Pharmaceutical development and technology.

[49]  G. L. Reid,et al.  Purification of Pharmaceutical Excipients with Supercritical Fluid Extraction , 2005, Pharmaceutical development and technology.

[50]  S. Badawy,et al.  Effect of Processing and Formulation Variables on the Stability of a Salt of a Weakly Basic Drug Candidate , 2005, Pharmaceutical development and technology.

[51]  S. Dharwadkar,et al.  Preformulation compatibility studies of etamsylate and fluconazole drugs with lactose by DSC , 2004 .

[52]  S. Hoag,et al.  Influence of methacrylic and acrylic acid polymers on the release performance of weakly basic drugs from sustained release hydrophilic matrices. , 2004, Journal of pharmaceutical sciences.

[53]  George Zografi,et al.  Effects of water vapor absorption on the physical and chemical stability of amorphous sodium indomethacin , 2004, AAPS PharmSciTech.

[54]  Jinyang Hong,et al.  Antioxidant‐Accelerated Oxidative Degradation: A Case Study of Transition Metal Ion Catalyzed Oxidation in Formulation , 2004, Pharmaceutical development and technology.

[55]  Ruben Lozano,et al.  Influence of Formaldehyde Impurity in Polysorbate 80 and PEG‐300 on the Stability of a Parenteral Formulation of BMS‐204352: Identification and Control of the Degradation Product , 2004, Pharmaceutical development and technology.

[56]  M. Al-omari,et al.  Amlodipine Besylate–Excipients Interaction in Solid Dosage Form , 2004, Pharmaceutical development and technology.

[57]  Dan Wu-Linhares,et al.  Is it the Method or the Process—Separating the Causes of Low Recovery , 2004, Drug development and industrial pharmacy.

[58]  Robert A Reed,et al.  The role of excipients and package components in the photostability of liquid formulations. , 2003, PDA journal of pharmaceutical science and technology.

[59]  Geoff G. Z. Zhang,et al.  Model-free treatment of the dehydration kinetics of nedocromil sodium trihydrate. , 2003, Journal of pharmaceutical sciences.

[60]  Y. Li,et al.  A new model for predicting moisture uptake by packaged solid pharmaceuticals. , 2003, International journal of pharmaceutics.

[61]  R. Borchardt,et al.  Reaction of a peptide with polyvinylpyrrolidone in the solid state. , 2003, Journal of pharmaceutical sciences.

[62]  C. R. Petts,et al.  Effect of moisture on polyvinylpyrrolidone in accelerated stability testing. , 2002, International journal of pharmaceutics.

[63]  Jiben Roy,et al.  Pharmaceutical impurities—A mini-review , 2002, AAPS PharmSciTech.

[64]  Franco Lombardo,et al.  Stabilization of Pharmaceuticals to Oxidative Degradation , 2002, Pharmaceutical development and technology.

[65]  Franco Lombardo,et al.  Hydrolysis in Pharmaceutical Formulations , 2002, Pharmaceutical development and technology.

[66]  F. Podczeck,et al.  The In Vitro Dissolution of Theophylline from Different Types of Hard Shell Capsules , 2002, Drug development and industrial pharmacy.

[67]  D. Cheesman,et al.  Stability of a second-generation cephalosporin veterinary mastitis formulation after electron beam irradiation , 2001, AAPS PharmSciTech.

[68]  L. Mazaletskaya,et al.  Catalytic Oxidative Deformylation of Polyethylene Glycols with the Participation of Molecular Oxygen , 2001 .

[69]  S. Badawy,et al.  Effect of salt form on chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms. , 2001, International journal of pharmaceutics.

[70]  S. Badawy,et al.  Application of sorption--desorption moisture transfer modeling to the study of chemical stability of a moisture sensitive drug product in different packaging configurations. , 2001, International journal of pharmaceutics.

[71]  V. Stella,et al.  Stability of Drugs and Dosage Forms , 2000, Springer US.

[72]  R. Oliyai,et al.  Effect of Carbonate Salts on the Kinetics of Acid-Catalyzed Dimerization of Adefovir Dipivoxil , 2000, Pharmaceutical Research.

[73]  A. Hussain,et al.  The Effect of Gelatin Cross-Linking on the Bioequivalence of Hard and Soft Gelatin Acetaminophen Capsules , 2000, Pharmaceutical Research.

[74]  J. Siepmann,et al.  pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[75]  T. Gold,et al.  Bioequivalence Study of Stressed and Nonstressed Hard Gelatin Capsules Using Amoxicillin as a Drug Marker and Gamma Scintigraphy to Confirm Time and GI Location of In Vivo Capsule Rupture , 2000, Pharmaceutical Research.

[76]  K. Hartauer,et al.  Influence of Peroxide Impurities in Povidone and Crospovidone on the Stability of Raloxifene Hydrochloride in Tablets: Identification and Control of an Oxidative Degradation Product , 2000, Pharmaceutical development and technology.

[77]  G. R. Heal,et al.  Solid–liquid diffusion controlled rate equations , 1999 .

[78]  Ping Gao,et al.  Tablet Dissolution Affected by a Moisture Mediated Solid-State Interaction Between Drug and Disintegrant , 1999, Pharmaceutical Research.

[79]  R. C. Williams,et al.  Effect of different acids on solid-state stability of an ester prodrug of a IIb/IIIa glycoprotein receptor antagonist. , 1999, Pharmaceutical development and technology.

[80]  S. Neau,et al.  The solution stability of vancomycin in the presence and absence of sodium carboxymethyl starch , 1998 .

[81]  R. Suryanarayanan,et al.  Polymorphism in anhydrous theophylline--implications on the dissolution rate of theophylline tablets. , 1997, Journal of pharmaceutical sciences.

[82]  N. Najib,et al.  Adsorption of ketotifen onto some pharmaceutical excipients , 1997 .

[83]  S. Varia,et al.  Dissolution instability of encapsulated marketed tablets , 1996 .

[84]  M. Kaufman,et al.  Characterization of a Solid State Reaction Product from a Lyophilized Formulation of a Cyclic Heptapeptide. A Novel Example of an Excipient-Induced Oxidation , 1996, Pharmaceutical Research.

[85]  G Zografi,et al.  How does residual water affect the solid-state degradation of drugs in the amorphous state? , 1996, Journal of pharmaceutical sciences.

[86]  R. Borchardt,et al.  Effects of reducing sugars on the chemical stability of human relaxin in the lyophilized state. , 1996, Journal of pharmaceutical sciences.

[87]  J. Glastrup.  Degradation of polyethylene glycol. A study of the reaction mechanism in a model molecule: Tetraethylene glycol , 1996 .

[88]  D. C. Zhao,et al.  Interactions between drug substances and excipients. 1. Fluorescence and HPLC studies of triazolophthalazine derivatives from hydralazine hydrochloride and starch. , 1996, Journal of pharmaceutical sciences.

[89]  S. Koda,et al.  Mechanism of Optical Isomerization of(S)-N-[1-(2-Fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk] [l,4]-benzodiazepine-3-y1]-1H-indole-2-carboxamide (FK480) in Soft Capsules Containing Polyethylene Glycol 400 and Glycerol , 1994, Pharmaceutical Research.

[90]  H. Toguchi,et al.  pH-independent controlled-release microspheres using polyglycerol esters of fatty acids. , 1994, Journal of pharmaceutical sciences.

[91]  S. Varia,et al.  Effects of different types of lactose and disintegrant on dissolution stability of hydrochlorothiazide capsule formulations , 1994 .

[92]  S. Ghodbane,et al.  In vitro adsorption-desorption of famotidine on microcrystalline cellulose , 1994 .

[93]  S. Varia,et al.  Effect of formaldehyde formation on dissolution stability of hydrochlorothiazide bead formulations , 1994 .

[94]  D. Bindra,et al.  Degradation of O6-Benzylguanine in Aqueous Polyethylene Glycol 400 (PEG 400) Solutions: Concerns with Formaldehyde in PEG 400 , 1994, Pharmaceutical Research.

[95]  V. Shah,et al.  Cross-linking of gelatin capsules and its relevance to their in vitro-in vivo performance. , 1994, Journal of pharmaceutical sciences.

[96]  Bruno C. Hancock,et al.  The Relationship Between the Glass Transition Temperature and the Water Content of Amorphous Pharmaceutical Solids , 1994, Pharmaceutical Research.

[97]  M. Kraml,et al.  The Dissolution and Bioavailability of Etodolac from Capsules Exposed to Conditions of High Relative Humidity and Temperatures , 1993, Pharmaceutical Research.

[98]  T. Durig,et al.  Identification of stabilizing and destabilizing effects of excipient-drug interactions in solid dosage form design , 1993 .

[99]  J. Rhie,et al.  The effect of aging on the dissolution of wet granulated tablets containing super disintegrants , 1993 .

[100]  K. Morris,et al.  Mechanism and Kinetics of Metal Ion-Mediated Degradation of Fosinopril Sodium , 1993, Pharmaceutical Research.

[101]  I. Ghebre-Sellassie,et al.  Current perspectives on the dissolution stability of solid oral dosage forms. , 1993, Journal of pharmaceutical sciences.

[102]  S. Koppenol,et al.  Use of the sorption-desorption moisture transfer model to assess the utility of a desiccant in a solid product , 1992 .

[103]  M. Mahjour,et al.  Characterization of adsorption behavior by solid dosage form excipients in formulation development , 1992 .

[104]  S. Yoshioka,et al.  Effect of Water Mobility on Drug Hydrolysis Rates in Gelatin Gels , 1992, Pharmaceutical Research.

[105]  西川 三喜男,et al.  Effect of Autoxidation of Hydrogenated Castor Oil Containing 60 Oxyethylene Groups on Degradation of Miconazole. , 1991 .

[106]  W. J. Irwin,et al.  Solid-state stability: the effect of grinding solvated excipients , 1991 .

[107]  P. Jarosz,et al.  Preformulation Studies Involving Moisture Uptake in Solid Dosage Forms , 1991, Pharmaceutical Research.

[108]  Valentino J. Stella,et al.  The nucleophilicity of dextrose, sucrose, sorbitol, and mannitol with p-nitrophenyl esters in aqueous solution. , 1990 .

[109]  G. Zografi,et al.  The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state , 1990 .

[110]  R. Strickley,et al.  Drug-Excipient Incompatibility Studies of the Dipeptide Angiotensin-Converting Enzyme Inhibitor, Moexipril Hydrochloride: Dry Powder vs Wet Granulation , 1990, Pharmaceutical Research.

[111]  Kitamura Satoshi,et al.  Effect of grinding on the solid-state stability of cefixime trihydrate , 1989 .

[112]  P. Finnegan,et al.  Solid-State Interaction of Magnesium Oxide and Ibuprofen to Form a Salt , 1989, Pharmaceutical Research.

[113]  P. York,et al.  The In‐vitro pH‐Dissolution Dependence and In‐vivo Bioavailability of Frusemide‐PVP Solid Dispersions , 1989, The Journal of pharmacy and pharmacology.

[114]  J. Newton,et al.  Thermal Studies on the Interaction of Water and Microcrystalline Cellulose , 1988, The Journal of pharmacy and pharmacology.

[115]  J. Carstensen,et al.  Decomposition of aspirin in the solid state in the presence of limited amounts of moisture II: Kinetics and salting-in of aspirin in aqueous acetic acid solutions. , 1988, Journal of pharmaceutical sciences.

[116]  Maria Angela Vandelli,et al.  The grinding of the polymorphic forms of chloramphenicol stearic ester in the presence of colloidal silica , 1988 .

[117]  W. Endres,et al.  [Oxidative degradation of linoleic acid methyl ester in suspensions of inorganic excipients. 1. Auto-oxidation in the presence of silicic acid products and aluminum oxide]. , 1987, Die Pharmazie.

[118]  S. Yoshioka,et al.  Stability of pilocarpine ophthalmic formulations. , 1986, Chemical & pharmaceutical bulletin.

[119]  M. B. Devani,et al.  Kinetic studies of the interaction between isoniazid and reducing sugars. , 1985, Journal of pharmaceutical sciences.

[120]  R. Rowe,et al.  Pitting—a defect on film-coated tablets , 1983 .

[121]  C. Larsen,et al.  The influence of carbohydrates and polyhydric alcohols on the stability of cephalosporins in aqueous solution , 1983 .

[122]  P. Perrier,et al.  Quantitative assessment of the effect of some excipients on nitrazepam stability in binary powder mixtures. , 1983, Journal of pharmaceutical sciences.

[123]  S. Yoshioka,et al.  Stability of solid dosage forms. II. Hydrolysis of meclofenoxate hydrochloride in commercial tablets. , 1983, Chemical & pharmaceutical bulletin.

[124]  K. Hirai,et al.  Kinetics and mechanism of the equilibrium reaction of triazolam in aqueous solution. , 1982, Journal of pharmaceutical sciences.

[125]  Y. Chien,et al.  Drug--disintegrant interactions: binding of oxymorphone derivatives. , 1981, Journal of pharmaceutical sciences.

[126]  S. Yoshioka,et al.  Stability of Sulpyrine. V. Oxidation with Molecular Oxygen in the Solid State , 1979 .

[127]  C. Larsen,et al.  Piperazinedione formation from reaction of ampicillin with carbohydrates and alcohols in aqueous solution , 1979 .

[128]  G. S. Banker,et al.  Surface chemistry of colloidal silica and a possible application to stabilize aspirin in solid matrixes. , 1979, Journal of pharmaceutical sciences.

[129]  C. Larsen,et al.  Kinetics and mechanism of the sucrose-accelerated degradation of penicillins in aqueous solution , 1978 .

[130]  Jerry March,et al.  Advanced Organic Chemistry: Reactions, Mechanisms, and Structure , 1977 .

[131]  M. Hanano,et al.  Decomposition of Acetylsalicylic Acid and Its Derivatives in Solid State , 1975 .

[132]  J. Carstensen,et al.  Decomposition of benzoic acid derivatives in solid state. , 1972, Journal of pharmaceutical sciences.

[133]  J. A. Mollica,et al.  Hydrolysis of benzothiadiazines. , 1971, Journal of pharmaceutical sciences.

[134]  L. Magid,et al.  Effect of silica gel on stability and biological availability of ascorbic acid. , 1970, Journal of pharmaceutical sciences.

[135]  A. Paruta,et al.  Consecutive first-order kinetic consideration of hydrocortisone hemisuccinate. , 1969, Journal of pharmaceutical sciences.

[136]  J. Carstensen,et al.  Degradation mechanisms for water-soluble drugs in solid dosage forms. , 1969, Journal of pharmaceutical sciences.

[137]  J. A. Mollica,et al.  Hydrolysis of hydrochlorothiazide. , 1969, Journal of pharmaceutical sciences.

[138]  F. Mallory,et al.  Photodegradation of polyethylene film , 1968 .

[139]  R. Huffman,et al.  Aminolysis of esters. VII. The reaction of lysine with phenyl acetate and triacetin. , 1967, The Journal of organic chemistry.

[140]  R. Tardif.  RELIABILITY OF ACCELERATED STORAGE TESTS TO PREDICT STABILITY OF VITAMINS (A, B-1, C) IN TABLETS. , 1965, Journal of pharmaceutical sciences.

[141]  B. J. Sciarrone,et al.  DECARBOXYLATION OF P-AMINOSALICYLIC ACID IN THE SOLID STATE. , 1964, Journal of pharmaceutical sciences.

[142]  S. M. Blaug,et al.  The stability of acetylsalicylic acid in suspension. , 1959, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

[143]  R. Plackett,et al.  THE DESIGN OF OPTIMUM MULTIFACTORIAL EXPERIMENTS , 1946 .

[144]  Wilhelm Jander,et al.  Reaktionen im festen Zustande bei höheren Temperaturen. Reaktionsgeschwindigkeiten endotherm verlaufender Umsetzungen , 1927 .

[145]  Syr Hui,et al.  US Patent Application , 2013 .

[146]  A. Narang,et al.  Effect of antioxidants and silicates on peroxides in povidone. , 2012, Journal of pharmaceutical sciences.

[147]  Arun Rastogi,et al.  Advanced Organic Chemistry: Reactions, Mechanisms and Structure , 2010 .

[148]  A. Narang,et al.  Chapter 6 – Excipient Compatibility , 2009 .

[149]  D. O. Kildsig,et al.  An examination of the moisture sorption characteristics of commercial magnesium stearate , 2008, AAPS PharmSciTech.

[150]  Neil Pearson,et al.  Implementation of Water Activity Testing to Replace Karl Fischer Water Testing for Solid Oral-Dosage Forms , 2007 .

[151]  Hui Xu,et al.  Evaluation of hydroperoxides in common pharmaceutical excipients. , 2007, Journal of pharmaceutical sciences.

[152]  Ich Harmonised,et al.  INTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE , 2006 .

[153]  J. Mcginity,et al.  Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid. , 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[154]  R. Johnson,et al.  Maillard reaction of lactose and fluoxetine hydrochloride, a secondary amine. , 1998, Journal of pharmaceutical sciences.

[155]  S. Vyazovkin,et al.  Kinetics in solids. , 1997, Annual review of physical chemistry.

[156]  S. Girois,et al.  Polym. Degrad. Stab. , 1996 .

[157]  P. Schmidt,et al.  Surface acidity of solid pharmaceutical excipients. I: Determination of the surface acidity , 1994 .

[158]  Raymond C Rowe,et al.  Handbook of Pharmaceutical Excipients , 1994 .

[159]  E. Huber,et al.  Investigation into the yellowing on aging of sabril® tablet cores , 1994 .

[160]  D. S. Risley,et al.  Drug-Excipient Interactions of Seproxetine Maleate Hemi-Hydrate: Isothermal Stress Methods , 1993 .

[161]  K. E. Gabr.  Effect of organic acids on the release patterns of weakly basic drugs from inert sustained release matrix tablets , 1992 .

[162]  A. P. Lötter,et al.  Compatibility Study Between Naproxen and Tablet Excipients Using Differential Scanning Calorimetry , 1990 .

[163]  G. Alderborn,et al.  Solid state stability of acetylsalicylic acid in binary mixtures with microcrystalline and microfine cellulose. , 1988, Acta pharmaceutica Suecica.

[164]  N. K. Patel,et al.  The Effect of Selected Direct Compression Excipients on the Stability of Aspirin as a Model Hydrolyzable Drug , 1988 .

[165]  J. KontnyMark.  DISTRIBUTION OF WATER IN SOLID PHARMACEUTICAL SYSTEMS , 1988 .

[166]  C. Ahlneck,et al.  Difference in effect of powdered and granular magnesium stearate on the solid state stability of acetylsalicylic acid , 1987 .

[167]  A. Weingart,et al.  Oxidativer Abbau von Linolsäuremethylester in Suspension anorganischer Hilfsstoffe. I: Autoxidation in Gegenwart von Kieselsäureprodukten und Aluminiumoxid , 1987 .

[168]  S. Yoshioka,et al.  Kinetics and mechanism of the solid-state decomposition of propantheline bromide. , 1986, Journal of pharmaceutical sciences.

[169]  J. Carstensen,et al.  Decarboxylation kinetics of 5-(tetradecyloxy)-2-furoic acid. , 1980, Journal of pharmaceutical sciences.

[170]  J. Swarbrick.  Drugs and the pharmaceutical sciences , 1975 .

[171]  H. Almond,et al.  Reaction of haloperidol with 5-(hydroxymethyl)-2-furfuraldehyde, an impurity in anhydrous lactose. , 1974, Journal of pharmaceutical sciences.