The emerging biology of the nitrite anion

Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics.

[1]  M. Gladwin,et al.  Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Mark R. Duranski,et al.  Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. , 2005, The Journal of clinical investigation.

[3]  H. H. Mitchell,et al.  THE ORIGIN OF THE NITRATES IN THE URINE , 1916 .

[4]  M. Gladwin,et al.  Erythrocytes are the major intravascular storage sites of nitrite in human blood. , 2005, Blood.

[5]  Martin Feelisch,et al.  Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues , 2005, Nature chemical biology.

[6]  S. Tannenbaum,et al.  The effect of nitrate intake on nitrite formation in human saliva. , 1976, Food and cosmetics toxicology.

[7]  M. Gladwin,et al.  Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation , 2003, Nature Medicine.

[8]  M. Gladwin,et al.  Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator , 2004, Nature Medicine.

[9]  N. Bryan,et al.  Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. , 2003, Free radical biology & medicine.

[10]  F. Murad,et al.  Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[11]  N. Bryan,et al.  Chemical nature of nitric oxide storage forms in rat vascular tissue , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Lundberg,et al.  Inorganic nitrate is a possible source for systemic generation of nitric oxide. , 2004, Free radical biology & medicine.

[13]  B. Freeman,et al.  Fatty Acid Transduction of Nitric Oxide Signaling , 2005, Journal of Biological Chemistry.

[14]  M. Gladwin,et al.  Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. , 2001, The Journal of clinical investigation.

[15]  R. Eisenthal,et al.  Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions , 1998, FEBS letters.

[16]  J. D. Coffman.  Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium , 1989 .

[17]  M. Murphy,et al.  Side-On Copper-Nitrosyl Coordination by Nitrite Reductase , 2004, Science.

[18]  M. Gladwin,et al.  Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. , 2005, JAMA.

[19]  M. Gladwin,et al.  Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. , 2005, The Journal of clinical investigation.

[20]  J. Brooks.  The Action of Nitrite on Haemoglobin in the Absence of Oxygen , 1937 .

[21]  M. Martí,et al.  QM-MM study of nitrite reduction by nitrite reductase of Pseudomonas aeruginosa , 2004 .

[22]  J. Zweier,et al.  Enzyme-independent formation of nitric oxide in biological tissues , 1995, Nature Medicine.

[23]  N. Bryan,et al.  Cellular targets and mechanisms of nitros(yl)ation: An insight into their nature and kinetics in vivo , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J. S. Haldane,et al.  THE PRESENCE POST MORTEM OF NITRICOXIDE-HAEMOGLOBIN , 1925 .

[25]  S R Tannenbaum,et al.  Nitrate biosynthesis in man. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Zhi Huang,et al.  Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. , 2006, Blood.

[27]  P. Sperryn,et al.  Blood. , 1989, British journal of sports medicine.

[28]  M. Marletta,et al.  Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. , 1988, Biochemistry.

[29]  P. Collins.  Vasodilatation: Vascular smooth muscle, peptides, autonomic nerves, and endothelium: Editor: Paul M. Vanhoutte Raven Press, New York, 1988; 572 pp.; $156.50; ISBN 0-88167-408-7 , 1990 .

[30]  D. Wink.  Ion implicated in blood pact , 2003, Nature Medicine.

[31]  R. Furchgott,et al.  Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. , 1953, The Journal of pharmacology and experimental therapeutics.

[32]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[33]  A. Ahluwalia,et al.  Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Jifeng Zhang,et al.  Nitrolinoleic acid: An endogenous peroxisome proliferator-activated receptor γ ligand , 2005 .

[35]  Jeff A. Cole,et al.  Nitrate, bacteria and human health , 2004, Nature Reviews Microbiology.

[36]  I. Lorkovic,et al.  Nitrite catalyzes reductive nitrosylation of the water-soluble Ferri-Heme model FeIII(TPPS) to FeII(TPPS)(NO). , 2003, Inorganic chemistry.

[37]  J. Hibbs,et al.  Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. , 1987, Science.

[38]  A. Kozlov,et al.  Nitrite reductase activity is a novel function of mammalian mitochondria , 1999, FEBS letters.

[39]  E. Weitzberg,et al.  Intragastric nitric oxide production in humans: measurements in expelled air. , 1994, Gut.

[40]  Marie-Luise Brennan,et al.  A Tale of Two Controversies , 2002, The Journal of Biological Chemistry.

[41]  D. Abernethy,et al.  Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction* , 2003, Journal of Biological Chemistry.

[42]  L. Ignarro,et al.  Endothelium‐Derived Relaxing Factor From Pulmonary Artery and Vein Possesses Pharmacologic and Chemical Properties Identical to Those of Nitric Oxide Radical , 1987, Circulation research.

[43]  F. Young.  Biochemistry , 1955, The Indian Medical Gazette.

[44]  O. E. Kolari,et al.  The history and use of nitrate and nitrite in the curing of meat. , 1975, Food and cosmetics toxicology.

[45]  M. Phillipson,et al.  Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. , 2004, The Journal of clinical investigation.

[46]  M. Feelisch,et al.  Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. , 1987, European journal of pharmacology.

[47]  M. Gladwin,et al.  The Reaction between Nitrite and Deoxyhemoglobin , 2005, Journal of Biological Chemistry.

[48]  J. Garthwaite,et al.  Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain , 1988, Nature.

[49]  T. Rassaf,et al.  Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[50]  P. Manoharan,et al.  Superoxide Produced in the Heme Pocket of the β-Chain of Hemoglobin Reacts with the β-93 Cysteine To Produce a Thiyl Radical† , 1998 .

[51]  P. Goldman,et al.  Nitrate synthesis in the germfree and conventional rat. , 1981, Science.

[52]  Xiaoping Liu,et al.  Characterization of the Effects of Oxygen on Xanthine Oxidase-mediated Nitric Oxide Formation* , 2004, Journal of Biological Chemistry.

[53]  Barry Halliwell,et al.  Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils , 1998, Nature.

[54]  R. Carrell,et al.  Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93. , 1977, Biochemical Journal.

[55]  T. Brunton.  ON THE USE OF NITRITE OF AMYL IN ANGINA PECTORIS. , 1867 .

[56]  F. Jensen.  Nitrite disrupts multiple physiological functions in aquatic animals. , 2003, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[57]  M. Doyle,et al.  Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites. , 1981, The Journal of biological chemistry.

[58]  J. Haldane.  The Red Colour of Salted Meat. (One Figure in the Text.) , 1901, Journal of Hygiene.

[59]  N. Benjamin,et al.  Stomach NO synthesis , 1994, Nature.