Allergic contact dermatitis to eyeglass frame nosepiece caused by tetraethylthiuram disulphide and resorcinol monobenzoate

with CHILD syndrome globally, with nearly 30 unique NSDHL mutations being described. The accumulation of toxic metabolites (3-hydroxy-3-methylglutaryl-coenzyme A and oxysterol) and a deficiency in cholesterol synthesis have been shown to be responsible for the pathogenesis of CHILD syndrome in the epidermis. It causes ipsilateral symptoms with the right side of body affected more often than the left. They have scaly erythematous plaques along the Blaschko’s lines and verruciform xanthoma with ptychotropism, without crossing the midline. Histopathology of the skin lesions usually demonstrates orthokeratosis alternating with parakeratosis, hypogranulosis, well-differentiated keratinocytes with irregular acanthosis, and foamy macrophages infiltration at the dermis. Treatments reported in the literature included topical keratolytic agents, emollient, and oral retinoids which only helped in the thickness of the epidermis. Surgical removal of diseased skin followed by skin graft that carries normal alleles has been successful. Recent pathogenesis-targeted therapy with topical 2% lovastatin and 2% cholesterol to the lesional area has been shown to be efficacious. Awareness of this syndrome should be raised among the clinicians as the current topical treatment is highly promising.