Molecular basis of endothelial dysfunction in sepsis.

[1]  M. Levi,et al.  Infection and inflammation and the coagulation system. , 2003, Cardiovascular research.

[2]  S. Cuzzocrea,et al.  Oxidative stress in septic shock and disseminated intravascular coagulation. , 2002, Free radical biology & medicine.

[3]  N. Reiling,et al.  Cutting Edge: Toll-Like Receptor (TLR)2- and TLR4-Mediated Pathogen Recognition in Resistance to Airborne Infection with Mycobacterium tuberculosis1 , 2002, The Journal of Immunology.

[4]  K. Müller,et al.  Heterogeneous expression of cell adhesion molecules by endothelial cells in ARDS , 2002, The Journal of pathology.

[5]  R. Vabulas,et al.  Cutting Edge: Myeloid Differentiation Factor 88 Deficiency Improves Resistance Against Sepsis Caused by Polymicrobial Infection1 , 2002, The Journal of Immunology.

[6]  N. Stassen,et al.  Interferon-γ gene polymorphisms and the development of sepsis in patients with trauma * , 2002 .

[7]  R. Andersson,et al.  NF-kappaB activation and inhibition: a review. , 2002, Shock.

[8]  Jean-Charles Preiser,et al.  Microvascular blood flow is altered in patients with sepsis. , 2002, American journal of respiratory and critical care medicine.

[9]  T. Hartung,et al.  Profound Differences in Leukocyte-Endothelial Cell Responses to Lipopolysaccharide Versus Lipoteichoic Acid1 , 2002, The Journal of Immunology.

[10]  D. Golenbock,et al.  Innate immune recognition of lipopolysaccharide by endothelial cells , 2002, Critical care medicine.

[11]  H. Ostermann Antithrombin III in Sepsis. New evidences and open questions. , 2002, Minerva anestesiologica.

[12]  S. Cuvelier,et al.  Selectins: critical mediators of leukocyte recruitment. , 2002, Seminars in immunology.

[13]  D. Healy New and Emerging Therapies for Sepsis , 2002, The Annals of pharmacotherapy.

[14]  A. Visintin,et al.  Toll‐like receptor 1 inhibits Toll‐like receptor 4 signaling in endothelial cells , 2002, European journal of immunology.

[15]  R. Bellomo,et al.  Endotoxin and cytokine removal in sepsis. , 2002, Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis.

[16]  R. Alon,et al.  From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts. , 2002, Seminars in immunology.

[17]  D. Gammella,et al.  Evaluation of endotoxin release and cytokine production induced by antibiotics in patients with Gram-negative nosocomial pneumonia , 2002, Critical care medicine.

[18]  D. Bullard,et al.  Mice genetically lacking endothelial selectins are resistant to the lethality in septic peritonitis. , 2002, Experimental and molecular pathology.

[19]  S. Gando Disseminated Intravascular Coagulation in Trauma Patients , 2001, Seminars in thrombosis and hemostasis.

[20]  M. Levi Pathogenesis and treatment of disseminated intravascular coagulation in the septic patient. , 2001, Journal of critical care.

[21]  B. Beutler,et al.  Sepsis begins at the interface of pathogen and host. , 2001, Biochemical Society transactions.

[22]  R. Postier,et al.  Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: A multicenter, randomized, placebo-controlled, single-blind, dose escalation study , 2001, Critical care medicine.

[23]  R. Flavell,et al.  Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 , 2001, Nature.

[24]  A. Visintin,et al.  Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[25]  N. Kobayashi,et al.  Bacterial Lipopolysaccharide Induces Transforming Growth Factor β and Hepatocyte Growth Factor through Tolllike Receptor 2 in Cultured Human Colon Cancer Cells , 2001, The Journal of international medical research.

[26]  M. Karin,et al.  Signal transduction by tumor necrosis factor and its relatives. , 2001, Trends in cell biology.

[27]  C. Esmon,et al.  Dysfunction of endothelial protein C activation in severe meningococcal sepsis. , 2001, The New England journal of medicine.

[28]  M. Abreu,et al.  Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide1 , 2001, The Journal of Immunology.

[29]  D. Schwartz,et al.  Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling , 2001 .

[30]  Derek C. Angus,et al.  Epidemiology of sepsis: An update , 2001, Critical care medicine.

[31]  J. Pober,et al.  TNF signaling in vascular endothelial cells. , 2001, Experimental and molecular pathology.

[32]  S. Akira,et al.  The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 , 2001, Nature.

[33]  J. Vincent,et al.  Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study , 2001, Critical care medicine.

[34]  A. Medvedev,et al.  Bacterial Lipopolysaccharide and IFN-γ Induce Toll-Like Receptor 2 and Toll-Like Receptor 4 Expression in Human Endothelial Cells: Role of NF-κB Activation1 , 2001, The Journal of Immunology.

[35]  R. Holzheimer Antibiotic Induced Endotoxin Release and Clinical Sepsis: a Review , 2001, Journal of chemotherapy.

[36]  G. Hodge,et al.  Synthesis and Surface Expression of CD14 by Human Endothelial Cells , 2001, Infection and Immunity.

[37]  E. Kiss-Toth,et al.  Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses1 , 2000, The Journal of Immunology.

[38]  S. Akira,et al.  A Toll-like receptor recognizes bacterial DNA , 2000, Nature.

[39]  B. Jaber,et al.  Mortality caused by sepsis in patients with end-stage renal disease compared with the general population. , 2000, Kidney international.

[40]  C. Dinarello,et al.  Proinflammatory cytokines. , 2000, Chest.

[41]  S. Vogel,et al.  Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 21 , 2000, The Journal of Immunology.

[42]  T. Honjo,et al.  ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice , 2000 .

[43]  D. Schwartz,et al.  TLR4 mutations are associated with endotoxin hyporesponsiveness in humans , 2000, Nature Genetics.

[44]  M. Arditi,et al.  Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells , 2000, The Journal of Biological Chemistry.

[45]  R. Dijkhuizen,et al.  Clinical and microbiological epidemiology of Streptococcus pneumoniae bacteraemia. , 2000, Journal of medical microbiology.

[46]  C. Lush,et al.  LPS tolerance in human endothelial cells: reduced PMN adhesion, E-selectin expression, and NF-kappaB mobilization. , 2000, American journal of physiology. Heart and circulatory physiology.

[47]  M. Wichmann,et al.  Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome , 2000, Intensive Care Medicine.

[48]  B. Beutler,et al.  Tlr4: central component of the sole mammalian LPS sensor. , 2000, Current opinion in immunology.

[49]  A. Aderem,et al.  Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[50]  G. Lonnemann,et al.  Tumor necrosis factor-α during continuous high-flux hemodialysis in sepsis with acute renal failure , 1999 .

[51]  G. Randolph,et al.  Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes , 1999, Journal of leukocyte biology.

[52]  O. Kemmotsu,et al.  Systemic activation of tissue-factor dependent coagulation pathway in evolving acute respiratory distress syndrome in patients with trauma and sepsis. , 1999, The Journal of trauma.

[53]  M. Sztein,et al.  Salmonella typhi Flagella Are Potent Inducers of Proinflammatory Cytokine Secretion by Human Monocytes , 1999, Infection and Immunity.

[54]  C. Ince,et al.  Microcirculatory oxygenation and shunting in sepsis and shock. , 1999, Critical care medicine.

[55]  R. Hotchkiss,et al.  Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. , 1999, Critical care medicine.

[56]  A. Hoeft,et al.  Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. , 1999, Critical care medicine.

[57]  Yoshinori Nagai,et al.  MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4 , 1999, The Journal of experimental medicine.

[58]  R. Menzel,et al.  Structures in Bacillus subtilis Are Recognized by CD14 in a Lipopolysaccharide Binding Protein-Dependent Reaction , 1999, Infection and Immunity.

[59]  S. Akira,et al.  Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. , 1999, Journal of immunology.

[60]  K. A. Kirkebøen,et al.  The role of nitric oxide in sepsis – an overview , 1999, Acta anaesthesiologica Scandinavica.

[61]  P. Murphy,et al.  Impaired Antibacterial Host Defense in Mice Lacking the N-formylpeptide Receptor , 1999, The Journal of experimental medicine.

[62]  D. Harrison,et al.  Reactive oxygen species and the control of vasomotor tone , 1999, Current hypertension reports.

[63]  J. Kelley,et al.  Human endothelium as a source of multifunctional cytokines: molecular regulation and possible role in human disease. , 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[64]  S. Goldblum,et al.  Bacterial Lipopolysaccharide Disrupts Endothelial Monolayer Integrity and Survival Signaling Events through Caspase Cleavage of Adherens Junction Proteins* , 1998, The Journal of Biological Chemistry.

[65]  T. V. van Kooten,et al.  Mechanisms of cell activation by heavy metal ions. , 1998, Journal of biomedical materials research.

[66]  P. Zabel,et al.  Gender differences in human sepsis. , 1998, Archives of surgery.

[67]  C. Janeway,et al.  MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. , 1998, Molecular cell.

[68]  Arthur S Slutsky,et al.  Multiple system organ failure. Is mechanical ventilation a contributing factor? , 1998, American journal of respiratory and critical care medicine.

[69]  J. Hasday,et al.  Endotoxin-Neutralizing Protein Protects against Endotoxin-Induced Endothelial Barrier Dysfunction , 1998, Infection and Immunity.

[70]  H. Mattie,et al.  Antibiotic-Induced Lipopolysaccharide (LPS) Release from Salmonella typhi: Delay between Killing by Ceftazidime and Imipenem and Release of LPS , 1998, Antimicrobial Agents and Chemotherapy.

[71]  M. Kaminishi,et al.  Endotoxin Binding and Elimination by Monocytes: Secretion of Soluble CD14 Represents an Inducible Mechanism Counteracting Reduced Expression of Membrane CD14 in Patients with Sepsis and in a Patient with Paroxysmal Nocturnal Hemoglobinuria , 1998, Infection and Immunity.

[72]  B. Finlay,et al.  Lipopolysaccharide induces apoptosis in a bovine endothelial cell line via a soluble CD14 dependent pathway. , 1998, Microbial pathogenesis.

[73]  H. Flad,et al.  Detection of lipopolysaccharide (LPS)-binding membrane proteins by immuno-coprecipitation with LPS and anti-LPS antibodies. , 1997, European journal of biochemistry.

[74]  D. Golenbock,et al.  CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin. , 1997, The Journal of surgical research.

[75]  I. Chaudry,et al.  Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis. , 1997, Archives of surgery.

[76]  G. Rune,et al.  Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection , 1997, Nature.

[77]  W. Hop,et al.  Interleukin 12 levels during the initial phase of septic shock with purpura in children: relation to severity of disease. , 1997, Cytokine.

[78]  H. Bluethmann,et al.  Molecules and mechanisms operating in septic shock: lessons from knockout mice. , 1997, Immunology today.

[79]  R. Pardi,et al.  Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines. , 1997, The American journal of physiology.

[80]  J. Christman,et al.  The role of nuclear factor-kappa B in cytokine gene regulation. , 1997, American journal of respiratory cell and molecular biology.

[81]  C. Kirkpatrick,et al.  THE INFLUENCE OF HEAT SHOCK PROTEIN 70 INDUCTION ON HEMODYNAMIC VARIABLES IN A PORCINE MODEL OF RECURRENT ENDOTOXEMIA , 1997, Shock.

[82]  T. Clemmer,et al.  Increased mortality of older patients with acute respiratory distress syndrome. , 1997, Chest.

[83]  A. Israël,et al.  IκB proteins: structure, function and regulation , 1997 .

[84]  E. Rackow,et al.  Monocyte response to bacterial toxins, expression of cell surface receptors, and release of anti-inflammatory cytokines during sepsis. , 1996, The Journal of laboratory and clinical medicine.

[85]  S. Paul,et al.  Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[86]  G. Fantuzzi,et al.  Effect of endotoxin in IL-1 beta-deficient mice. , 1996, Journal of immunology.

[87]  C. Dinarello,et al.  Biologic basis for interleukin-1 in disease. , 1996, Blood.

[88]  Anand Kumar,et al.  Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum , 1996, The Journal of experimental medicine.

[89]  F. Stüber,et al.  A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis. , 1996, Critical care medicine.

[90]  R. Welch,et al.  Battling against host phagocytes: the wherefore of the RTX family of toxins? , 1995, Infectious agents and disease.

[91]  C. Hack,et al.  Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. , 1995, Blood.

[92]  J. Wautier,et al.  Endothelial cells in culture: a model to study in vitro vascular toxicity. , 1995, Toxicology in vitro : an international journal published in association with BIBRA.

[93]  S. Raja,et al.  Photolabeling of a pore-forming toxin with the hydrophobic probe 2- [3H]diazofluorene. Identification of membrane-inserted segments of Staphylococcus aureus alpha-toxin , 1995, The Journal of Biological Chemistry.

[94]  S. Sriskandan,et al.  The pathogenesis of septic shock. , 1995, The Journal of infection.

[95]  F. Bach,et al.  Regulation of the Tissue Factor Promoter in Endothelial Cells , 1995, The Journal of Biological Chemistry.

[96]  P. Ward,et al.  Mechanisms of endothelial cell injury in acute inflammation. , 1994, Shock.

[97]  J. Pearson,et al.  Endothelial cell function and thrombosis. , 1994, Bailliere's best practice & research. Clinical haematology.

[98]  P. Ferrara,et al.  The two soluble forms of the lipopolysaccharide receptor, CD14: Characterization and release by normal human monocytes , 1994, European journal of immunology.

[99]  S. Hauptmann,et al.  Skeletal muscle oedema and muscle fibre necrosis during septic shock. Observations with a porcine septic shock model , 1994, Virchows Archiv.

[100]  S. Opal,et al.  Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. , 1994, JAMA.

[101]  R. F. Johnston,et al.  Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial , 1994 .

[102]  F. Cerra,et al.  Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction. , 1994, JAMA.

[103]  R. Sittl,et al.  Increased fMet-Leu-Phe receptor expression and altered superoxide production of neutrophil granulocytes in septic and posttraumatic patients , 1993, The clinical investigator.

[104]  S. Goyert,et al.  Neutrophil CD14: biochemical properties and role in the secretion of tumor necrosis factor-alpha in response to lipopolysaccharide. , 1993, Journal of immunology.

[105]  R. Ulevitch,et al.  Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[106]  B. Finlay,et al.  Soluble CD14 participates in the response of cells to lipopolysaccharide , 1992, The Journal of experimental medicine.

[107]  B. Hazenberg,et al.  Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute‐phase proteins during the treatment of severe sepsis in humans , 1992, Critical care medicine.

[108]  P. Ward Mechanisms of endothelial cell injury. , 1991, The Journal of laboratory and clinical medicine.

[109]  L. Moldawer,et al.  IL-8 in septic shock, endotoxemia, and after IL-1 administration. , 1991, Journal of immunology.

[110]  W. Fiers,et al.  Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro. , 1991, The American journal of pathology.

[111]  R. Ulevitch,et al.  Structure and function of lipopolysaccharide binding protein. , 1990, Science.

[112]  R. Ulevitch,et al.  CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. , 1990, Science.

[113]  D. Chaplin,et al.  Genetic variability at the human tumor necrosis factor loci. , 1990, Journal of immunology.

[114]  P. Marrack,et al.  The staphylococcal enterotoxins and their relatives. , 1990, Science.

[115]  J. Haas,et al.  Inhibition of lipopolysaccharide‐induced in vitro desensitization by interferon‐γ , 1990, European journal of immunology.

[116]  A. Groeneveld,et al.  Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. , 1990, Critical care medicine.

[117]  S. Zuckerman,et al.  Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression. , 1989, Journal of immunology.

[118]  S. Goyert,et al.  The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. , 1988, Journal of immunology.

[119]  J. McCutchan,et al.  PREVENTION OF GRAM-NEGATIVE SHOCK AND DEATH IN SURGICAL PATIENTS BY ANTIBODY TO ENDOTOXIN CORE GLYCOLIPID , 1985, The Lancet.

[120]  P A Ward,et al.  Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. , 1984, The Journal of biological chemistry.

[121]  C. Esmon,et al.  Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. , 1981, The Journal of biological chemistry.

[122]  R. L. Fulton,et al.  Multiple system organ failure. The role of uncontrolled infection. , 1980, Archives of surgery.

[123]  R. Ulevitch,et al.  The effects of bacterial endotoxins on host mediation systems. A review. , 1978, The American journal of pathology.

[124]  K. Smith,et al.  Toll-like receptor-5 and the innate immune response to bacterial flagellin. , 2002, Current topics in microbiology and immunology.

[125]  W. Muller,et al.  CD99 plays a major role in the migration of monocytes through endothelial junctions , 2002, Nature Immunology.

[126]  M. Pinsky Sepsis: a pro- and anti-inflammatory disequilibrium syndrome. , 2001, Contributions to nephrology.

[127]  C. McCall,et al.  Molecular mechanisms responsible for endotoxin tolerance. , 1998, Progress in clinical and biological research.

[128]  K. Anderson,et al.  A conserved signaling pathway: the Drosophila toll-dorsal pathway. , 1996, Annual review of cell and developmental biology.

[129]  H. Ziegler-Heitbrock Molecular mechanism in tolerance to lipopolysaccharide. , 1995, Journal of inflammation.

[130]  T. Caffrey Multiple organ failure syndrome in the 1990s , 1995 .

[131]  R. Tompkins,et al.  Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. , 1990, The Journal of infectious diseases.

[132]  H. Schlayer,et al.  Enhancement of neutrophil adherence to isolated rat liver sinusoidal endothelial cells by supernatants of lipopolysaccharide-activated monocytes. Role of tumor necrosis factor. , 1987, Journal of hepatology.