Hepcidin regulation of iron transport.

The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.

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[14]  Xiaoling Xu,et al.  A Role of Smad4 in Iron Metabolism through the Positive Regulation of Hepcidin Expression , 2022 .

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[22]  Raymond T Chung,et al.  Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression , 2006, Nature Genetics.

[23]  Elizabeta Nemeth,et al.  IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. , 2004, The Journal of clinical investigation.

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[32]  Christina H. Park,et al.  Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver* , 2001, The Journal of Biological Chemistry.

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[38]  V. Nizet,et al.  TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. , 2006, Blood.

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[40]  W. Sundquist,et al.  The molecular mechanism of hepcidin-mediated ferroportin down-regulation. , 2007, Molecular biology of the cell.

[41]  M. Hentze,et al.  STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. , 2007, Blood.

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[45]  V. Ganapathy,et al.  Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. , 2008, The Biochemical journal.

[46]  S. Srai,et al.  Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells , 2007, Gut.

[47]  N. Andrews,et al.  Hereditary Hemochromatosis Protein, HFE, Interaction with Transferrin Receptor 2 Suggests a Molecular Mechanism for Mammalian Iron Sensing* , 2006, Journal of Biological Chemistry.