IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
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M. White | S. Aaronson | Ling-mei Wang | L. M. Wang | J. Pierce | M. G. Myers | X. J. Sun | X. Sun
[1] A. Ullrich,et al. The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. , 1993, The EMBO journal.
[2] G. Lienhard,et al. Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[3] R. Aebersold,et al. The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning. , 1993, Biochimica et biophysica acta.
[4] J. Gutkind,et al. IL‐4 activates a distinct signal transduction cascade from IL‐3 in factor‐dependent myeloid cells. , 1992, The EMBO journal.
[5] B. Neel,et al. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[6] C. Kahn,et al. Expression and function of IRS-1 in insulin signal transmission. , 1992, The Journal of biological chemistry.
[7] M. White,et al. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[8] B. Margolis,et al. Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. , 1992, The EMBO journal.
[9] A. Ullrich,et al. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling , 1992, Cell.
[10] V. Duronio,et al. p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[11] J. McCubrey,et al. Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism , 1991 .
[12] C. Kahn,et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein , 1991, Nature.
[13] A. Ullrich,et al. Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells. , 1991, Biochemistry.
[14] M. Nakafuku,et al. Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[15] J B Gibbs,et al. Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP). , 1990, The Journal of biological chemistry.
[16] A. Ullrich,et al. Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit. , 1990, The Journal of biological chemistry.
[17] J. Banchereau,et al. Molecular cloning of a cDNA encoding the human interleukin 4 receptor. , 1990, International immunology.
[18] Alan I. Alpert,et al. The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms , 1989, Cell.
[19] A. Ullrich,et al. Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity , 1988, Cell.
[20] J. Schlessinger,et al. Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells. , 1988, Science.
[21] J. Lowenthal,et al. Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells. , 1988, Journal of immunology.
[22] A. Ullrich,et al. Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells , 1987, Cell.
[23] A. Ullrich,et al. Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. , 1987, The Journal of biological chemistry.
[24] J. Watson,et al. Induction of IL 2 responsiveness in a murine IL 3-dependent cell line. , 1985, Journal of immunology.
[25] C. Kahn,et al. Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells , 1985, Nature.
[26] C. Kahn,et al. Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. , 1982, Science.
[27] E. Scolnick,et al. Growth of factor-dependent hemopoietic precursor cell lines , 1980, The Journal of experimental medicine.