Localized detection of glioma glycolysis using edited 1H MRS

In vivo 1H MRS can be used to detect and quantify the lactate resonance at 1.3 ppm provided that overlapping lipid resonances are eliminated. A homonuclear spectral editing method was developed to acquire uncontaminated 1H spectra of lactate with adiabatic pulses. An advantage of the adiabatic pulse sequence is the ability to induce uniform flip angles and to maximize sensitivity in applications employing surface coil transmitters which produce highly inhomogeneous B1. Glycolytic activity in an intracerebral C6 glioma in rats was monitored by using adiabatic editing sequences to observe [3‐13C]lactate produced from infused [1‐13C]glucose. Acute hyperglycemia (serum glucose >22 mM, n = 10) had no significant effect (P = 0.08) on the total ([12C]+ [13C]) tumor lactate signal intensity.

[1]  M. Décorps,et al.  Phased spectroscopic images: Application to the characterization of the 1H 1.3‐ppm resonance in intracerbral tumors in the rat , 1993, Magnetic resonance in medicine.

[2]  C. Hanstock,et al.  Localized in Vivo proton spectroscopy using depth-pulse spectral editing , 1987 .

[3]  C S Patlak,et al.  A method to obtain infusion schedules for prescribed blood concentration time courses. , 1976, Journal of applied physiology.

[4]  Roger J. Ordidge,et al.  Image-selected in Vivo spectroscopy (ISIS). A new technique for spatially selective nmr spectroscopy , 1986 .

[5]  Ad Bax,et al.  Separation of the different orders of NMR multiple-quantum transitions by the use of pulsed field gradients , 1980 .

[6]  A Macovski,et al.  A reduced power selective adiabatic spin‐echo pulse sequence , 1991, Magnetic resonance in medicine.

[7]  R. Kimmich,et al.  Single‐scan volume‐selective spectral editing by homonuclear polarization transfer , 1989, Magnetic resonance in medicine.

[8]  O. Warburg.  [Origin of cancer cells]. , 1956, Oncologia.

[9]  Michael Garwood,et al.  Symmetric pulses to induce arbitrary flip angles with compensation for rf inhomogeneity and resonance offsets , 1991 .

[10]  B. Ross,et al.  Carbohydrate metabolism of the rat c6 glioma. an in vivo 13c and in vitro 1h magnetic resonance spectroscopy study , 1988, NMR in biomedicine.

[11]  Christopher J. Hardy,et al.  Efficient adiabatic fast passage for NMR population inversion in the presence of radiofrequency field inhomogeneity and frequency offsets , 1986 .

[12]  R G Shulman,et al.  1H homonuclear editing of rat brain using semiselective pulses. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[13]  K. Uğurbil,et al.  NMR chemical shift imaging in three dimensions. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[14]  A. J. Shaka,et al.  An improved sequence for broadband decoupling: WALTZ-16 , 1983 .

[15]  H. Merkle,et al.  Spatially localized in vivo 1H magnetic resonance spectroscopy of an intracerebral rat glioma , 1992, Magnetic resonance in medicine.

[16]  R G Shulman,et al.  Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[17]  R A Brooks,et al.  Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography , 1982, Neurology.

[18]  M. Décorps,et al.  Spectral editing in Vivo by homonuclear polarization transfer , 1987 .

[19]  A. Wilman,et al.  Lactate editing by means of selective-pulse filtering of both zero-and double-quantum coherence signals , 1990 .

[20]  C. Dumoulin,et al.  Suppression of uncoupled spins by single-quantum homonuclear polarization transfer , 1986 .

[21]  G. Chiro.  Positron emission tomography using [18F] fluorodeoxyglucose in brain tumors. A powerful diagnostic and prognostic tool. , 1987 .

[22]  H. Merkle,et al.  In Vivo 31P and 1H NMR studies of rat brain tumor pH and blood flow during acute hyperglycemia: Differential effects between subcutaneous and intracerebral locations , 1989 .

[23]  Michael Garwood,et al.  Amplitude- and frequency-modulated pulses to achieve 90° plane rotations with inhomogeneous B1 fields , 1987 .

[24]  M. Garwood,et al.  Adiabatic DANTE sequences for B1-insensitive narrowband inversion , 1992 .

[25]  R. Shulman,et al.  Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1‐13C]glucose , 1986, Magnetic resonance in medicine.

[26]  A. Benabid,et al.  Proton spectroscopic imaging: A tool for studying intracerebral tumor models in rat , 1991, Magnetic resonance in medicine.

[27]  Jullie W Pan,et al.  A fully localized 1H homonuclear editing sequence to observe lactate in human skeletal muscle after exercise , 1989 .

[28]  Pines,et al.  Broadband and adiabatic inversion of a two-level system by phase-modulated pulses. , 1985, Physical review. A, General physics.

[29]  D. Gadian,et al.  Tissue metabolism studied in vivo by nuclear magnetic resonance. , 1986, Quarterly journal of experimental physiology.

[30]  Gareth A. Morris,et al.  A simple pulse sequence for selective excitation in Fourier transform NMR , 1976 .

[31]  R G Shulman,et al.  1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[32]  D. Gadian,et al.  A method for lactate detection in vivo by spectral editing without the need for double irradiation , 1986 .

[33]  Geoffrey Bodenhausen,et al.  Suppression of artifacts in two-dimensional J spectroscopy , 1977 .

[34]  A. Benabid,et al.  In vivo 1H NMR spectroscopy of an intracerebral glioma in the rat , 1989, Magnetic resonance in medicine.

[35]  M. S. Silver,et al.  Highly selective {π}/{2} and π pulse generation , 1984 .

[36]  David T. Pegg,et al.  Uniform sample excitation with surface coils for in vivo spectroscopy by adiabatic rapid half passage , 1986 .

[37]  R. Hurd,et al.  Metabolite specific proton magnetic resonance imaging. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[38]  T. Jue.  Two for one: Simultaneously winnowing the 13C1H and 12C1H signals using only 1H pulses , 1987 .

[39]  W. Perman,et al.  Spatially resolved high resolution spectroscopy by “four-dimensional” NMR , 1983 .

[40]  Pierre Plateau,et al.  Exchangeable proton NMR without base-line distorsion, using new strong-pulse sequences , 1982 .

[41]  M. Garwood,et al.  Heteronuclear spectral editing with adiabatic pulses , 1991 .

[42]  Richard R. Ernst,et al.  Selective detection of multiple quantum transitions in NMR by two-dimensional spectroscopy , 1977 .

[43]  T Jones,et al.  In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas , 1983, Annals of neurology.

[44]  A. Howseman,et al.  Localized proton NMR observation of [3‐13C] lactate in stroke after [1‐13C] glucose infusion , 1991, Magnetic resonance in medicine.

[45]  Albert Macovski,et al.  A selective adiabatic spin-echo pulse , 1989 .

[46]  Abass Alavi,et al.  Positron emission tomography in patients with glioma a predictor of prognosis , 1988, Cancer.

[47]  Richard R. Ernst,et al.  Product operator formalism for the description of NMR pulse experiments , 1984 .

[48]  C. Sotak,et al.  The unequivocal determination of in vivo lactic acid using two-dimensional double-quantum coherence-transfer spectroscopy , 1988 .

[49]  R. Kimmich,et al.  Double‐quantum filtered volume‐selective NMR spectroscopy , 1989, Magnetic resonance in medicine.