Flexible printed-circuit probe for electrophysiology

Photofabrication techniques have been used to produce a nickel-iron microelectrode array on Kapton film specifically designed for biological implantation. The probe is 2·5 mm×2 mm and carries four tissue terminals, each 2 μm in width. Both spontaneous and evoked potentials have been recorded from frog sciatic nerve. Developmental possibilities for the probe are fully discussed.

[1]  B Blum,et al.  A microdrive for the independent manipulation of four microelectrodes. , 1965, IEEE transactions on bio-medical engineering.

[2]  G M Clark,et al.  A multiple-electrode array for a cochlear implant , 1976, The Journal of Laryngology & Otology.

[3]  T B Fryer,et al.  A review of implant telemetry systems. , 1974, Biotelemetry.

[4]  K. Frank,et al.  CHAPTER 2 – MICROELECTRODES FOR RECORDING AND STIMULATION , 1964 .

[5]  G. Loeb,et al.  A miniature microelectrode array to monitor the bioelectric activity of cultured cells. , 1972, Experimental cell research.

[6]  K D Wise,et al.  An evaluation of photoengraved microelectrodes for extracellular single-unit recording. , 1973, IEEE transactions on bio-medical engineering.

[7]  M. Hatzakis,et al.  Electron Resists for Microcircuit and Mask Production , 1969 .

[8]  H. S. Gasser,et al.  Electrical Signs of Nervous Activity , 1937 .

[9]  D. Maydan,et al.  A Structural Investigation of the Laser Machining of Thin Bismuth Films , 1971 .

[10]  R. S. Pickard.  Printed circuit microelectrodes , 1979, Trends in Neurosciences.

[11]  D. Y. Solandt.  Electrical Signs Of Nervous Activity. By Joseph Erlanger and Herbert S. Gasser. (Philadelphia: University of Pennsylvania Press; London: Humphrey Milford, Oxford University Press, 1937.) , 1937 .

[12]  D. Robinson,et al.  The electrical properties of metal microelectrodes , 1968 .

[13]  M. Sonn,et al.  A prototype flexible microelectrode array for implant-prosthesis applications , 1974, Medical and biological engineering.

[14]  R. Stein,et al.  Regeneration Electrode Units: Implants for Recording from Single Peripheral Nerve Fibers in Freely Moving Animals , 1974, Science.

[15]  J. Skrzypek,et al.  Manufacture of Metal Microelectrodes with the Scanning Electron Microscope , 1975, IEEE Transactions on Biomedical Engineering.

[16]  Robin P. Michelson,et al.  The Results of Electrical Stimulation of the Cochlea in Human Sensory Deafness , 1971, The Annals of otology, rhinology, and laryngology.

[17]  K. Wise,et al.  An integrated-circuit approach to extracellular microelectrodes. , 1970, IEEE transactions on bio-medical engineering.

[18]  Seiki Harada,et al.  A Novel Planar Multilevel Interconnection Technology Utilizing Polyimide , 1973 .

[19]  R. Pickard,et al.  Printed circuit microelectrodes and their application to honeybee brain. , 1976, The Journal of experimental biology.

[20]  Edward L. McCaffery.  Laboratory preparation for macromolecular chemistry , 1970 .

[21]  K. Lehovec,et al.  Impedance of a semiconductor surface at flat band condition , 1965 .

[22]  B. Hille,et al.  Electrophysiology of the Peripheral Myelinated Nerve , 1976 .

[23]  Kensall D. Wise,et al.  A Low-Capacitance Multielectrode Probe for Use in Extracellular Neurophysiology , 1975, IEEE Transactions on Biomedical Engineering.

[24]  G. E. Loeb,et al.  Analysis and microelectronic design of tubular electrode arrays intended for chronic, multiple singleunit recording from captured nerve fibres , 1977, Medical and Biological Engineering and Computing.

[25]  Charles Nicholson,et al.  Intracellular Staining in Neurobiology , 1973, Springer Berlin Heidelberg.

[26]  P. Mill,et al.  Ventilatory muscle activity in restrained and free-swimming dragonfly larvae (Odonata: Anisoptera) , 1975, Journal of comparative physiology.

[27]  G R Hanna,et al.  A rapid and simple method for the fabrication of arrays of recording electrodes. , 1968, Electroencephalography and clinical neurophysiology.

[28]  Anthony M. Dymond,et al.  Characteristics of the Metal-Tissue Interface of Stimulation Electrodes , 1976, IEEE Transactions on Biomedical Engineering.

[29]  P.E.K. Donaldson.  Experimental visual prosthesis , 1973 .