The emergence of genomic psychology

To say that psychology was born out of biology is not a huge overstatement. Many of the founders of modern psychology were trained in medicine, physiology or the natural sciences, and regarded psychology as the physiology of behaviour. Wilhelm Wundt, who founded modern experimental and cognitive psychology, and published the Principles of Physiological Psychology in 1874, studied medicine and worked as an assistant to the physicist Herrmann von Helmholtz. William James, who is widely regarded as a founder of psychology in the USA, earned a medical degree and, in 1890, published the influential Principles of Psychology , which starts with a chapter on brain function. Ivan Pavlov, whose work in the 1890s on the conditioning of reflexes in dogs gave rise to behaviourism, received his doctorate in the natural sciences. ![][1] Given its roots in the biological sciences, it is not surprising that psychology has absorbed many technical innovations from biological research, although their incorporation has been confined largely to the subfield of biological psychology. This has changed notably over the past 15 years, as investigators have begun to use non‐invasive functional neuroimaging technologies to study human behaviour and psychological processes. Today, this type of analysis cuts across all domains of psychology—clinical, cognitive, developmental and social/health—and represents the lowest level of the reductionist ladder, as it descends from behaviour to neurons. Here, I suggest that the field of psychology is about to undergo another transformation that will affect all of its subfields, and that will push analyses further down to the level of the genome. This transformation is inspired by genomics—defined as the molecular study of the entire genome, as opposed to the genetics of single genes—and by the interactions among genes, and those between genes and the environment. Genomics is more powerful than quantitative genetics—which has produced studies based on … [1]: /embed/graphic-1.gif

[1]  M. Burmeister,et al.  Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits , 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[2]  P Riederer,et al.  Allelic Variation of Human Serotonin Transporter Gene Expression , 1996, Journal of neurochemistry.

[3]  N. Martin,et al.  The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression , 2005, Psychological Medicine.

[4]  Lin He,et al.  Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). , 2006, Human molecular genetics.

[5]  H Völzke,et al.  Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden , 2005, Molecular Psychiatry.

[6]  M. Munafo,et al.  Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis , 2005, Molecular Psychiatry.

[7]  L. Passamonti,et al.  Monoamine Oxidase-A Genetic Variations Influence Brain Activity Associated with Inhibitory Control: New Insight into the Neural Correlates of Impulsivity , 2006, Biological Psychiatry.

[8]  F. Crawford,et al.  DRD4 and novelty seeking: results of meta-analyses. , 2002, American journal of medical genetics.

[9]  A. Meyer-Lindenberg,et al.  5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression , 2005, Nature Neuroscience.

[10]  R Plomin,et al.  Gene–environment interaction analysis of serotonin system markers with adolescent depression , 2004, Molecular Psychiatry.

[11]  R. Plomin,et al.  Genetics and Psychology: Beyond Heritability , 2001 .

[12]  F. Bloom,et al.  Synaptic organization of serotonin‐immunoreactive fibers in primary visual cortex of the macaque monkey , 1988, The Journal of comparative neurology.

[13]  R. Plomin,et al.  Why are Children in the Same Family So Different? Nonshared Environment a Decade Later , 2001, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[14]  D. Posthuma,et al.  Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families , 2006, Genes, Brain and Behavior.

[15]  Mary L Marazita,et al.  Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis , 2002, Psychiatric genetics.

[16]  Brien Riley,et al.  The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. , 2005, Archives of general psychiatry.

[17]  H. V. Van Tol,et al.  Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants , 1995, Journal of neurochemistry.

[18]  P. Sham,et al.  A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds. , 2005, Journal of child psychology and psychiatry, and allied disciplines.

[19]  J. Flint,et al.  Social Adversity, the Serotonin Transporter (5-HTTLPR) Polymorphism and Major Depressive Disorder , 2006, Biological Psychiatry.

[20]  G. Parker,et al.  Personality as a Vulnerability Factor to Depression , 1991, British Journal of Psychiatry.

[21]  R Todd Constable,et al.  Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  K. Lesch,et al.  Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region , 1996, Science.

[23]  Eliza Congdon,et al.  Neural correlates of epigenesis , 2006, Proceedings of the National Academy of Sciences.

[24]  D. Murphy,et al.  Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking , 1996, Nature Genetics.

[25]  David Coghill,et al.  The genetics of attention-deficit/hyperactivity disorder , 2009, Expert review of neurotherapeutics.

[26]  Mats Fredrikson,et al.  Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia , 2004, Neuroscience Letters.

[27]  Michael F Egan,et al.  A susceptibility gene for affective disorders and the response of the human amygdala. , 2005, Archives of general psychiatry.

[28]  Michael J Meaney,et al.  Epigenetic programming by maternal behavior , 2004, Nature Neuroscience.

[29]  P. Gorwood,et al.  Méta-analyse des gènes candidats dans le trouble déficit attentionnel avec hyperactivité (TDAH) , 2005 .

[30]  Ahmad R. Hariri,et al.  Serotonin Transporter Genotype (5-HTTLPR): Effects of Neutral and Undefined Conditions on Amygdala Activation , 2007, Biological Psychiatry.

[31]  John A. Detre,et al.  Genetic Variation in Serotonin Transporter Alters Resting Brain Function in Healthy Individuals , 2007, Biological Psychiatry.

[32]  M. Egan,et al.  The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function , 2003, Cell.

[33]  R. Busch,et al.  A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety , 2004, Molecular Psychiatry.

[34]  A. Caspi,et al.  Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , 2003, Science.

[35]  M. Egan,et al.  Serotonin Transporter Genetic Variation and the Response of the Human Amygdala , 2002, Science.

[36]  R. Ebstein,et al.  Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking , 1996, Nature Genetics.

[37]  A. Meyer-Lindenberg,et al.  Prefrontal-Hippocampal Coupling During Memory Processing Is Modulated by COMT Val158Met Genotype , 2006, Biological Psychiatry.

[38]  D. Posthuma,et al.  The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts , 2006, Molecular Psychiatry.

[39]  A. Kluger,et al.  A meta-analysis of the association between DRD4 polymorphism and novelty seeking , 2002, Molecular Psychiatry.

[40]  R. Plomin,et al.  A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability , 2004, Molecular Psychiatry.

[41]  R. Letz,et al.  Examination of the Effect of the Polymorphic CGG Repeat in the FMR1 Gene on Cognitive Performance , 2005, Behavior genetics.

[42]  John H Krystal,et al.  Social supports and serotonin transporter gene moderate depression in maltreated children. , 2004, Proceedings of the National Academy of Sciences of the United States of America.