Phase I study of evofosfamide, an investigational hypoxia‐activated prodrug, in patients with advanced leukemia
暂无分享,去创建一个
M. Konopleva | M. Andreeff | H. Kantarjian | J. Cortes | G. Borthakur | E. Jabbour | S. Kroll | Deborah A. Thomas | S. Konoplev | T. Pearce | S. Faderl | Damian R Handisides | M. Richie | J. Cortes | K. Harutyunyan | T. Badar | J. Benito | D. Thomas | Damian R. Handisides | Karine G. Harutyunyan | Talha Badar | Damian R. Handisides
[1] J. Velez,et al. Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models , 2015, Clinical Cancer Research.
[2] M. Borad,et al. Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[3] K. Ganjoo,et al. Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[4] M. Wetzler,et al. Activity of the Hypoxia-Activated Prodrug, TH-302, in Preclinical Human Acute Myeloid Leukemia Models , 2013, Clinical Cancer Research.
[5] J. Laubach,et al. Phase I study of TH-302, an investigational hypoxia-targeted drug, and dexamethasone in patients with relapsed/refractory multiple myeloma. , 2013 .
[6] M. Konopleva,et al. Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment , 2012, Cancer biology & therapy.
[7] Damien J. Ferraro,et al. TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules , 2012, Cancer Chemotherapy and Pharmacology.
[8] Kyeong Lee,et al. Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. , 2012, European journal of medicinal chemistry.
[9] E. Ebert,et al. Gastrointestinal manifestations of leukemia , 2012, Journal of gastroenterology and hepatology.
[10] Charles P. Lin,et al. Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features. , 2011, Blood.
[11] D. Campana,et al. Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104 , 2011, PloS one.
[12] W. Wilson,et al. Targeting hypoxia in cancer therapy , 2011, Nature Reviews Cancer.
[13] K. Ganjoo,et al. A Phase I Study of the Safety and Pharmacokinetics of the Hypoxia-Activated Prodrug TH-302 in Combination with Doxorubicin in Patients with Advanced Soft Tissue Sarcoma , 2011, Oncology.
[14] P. Starostik,et al. Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia. , 2011, Leukemia research.
[15] Suzanne F. Jones,et al. Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of TH-302, a Hypoxia-Activated Prodrug, in Patients with Advanced Solid Malignancies , 2011, Clinical Cancer Research.
[16] C. Hart,et al. Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. , 2010, Blood.
[17] G. Semenza. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics , 2010, Oncogene.
[18] Bob Löwenberg,et al. Review Articles (434 articles) , 2008 .
[19] Jun O. Liu,et al. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells , 2009, Proceedings of the National Academy of Sciences.
[20] P. Jones,et al. Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study , 2008, Clinical Cancer Research.
[21] Rachelle S. Singleton,et al. Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104 , 2007, Clinical Cancer Research.
[22] M. Davila. Neutropenic enterocolitis: Current issues in diagnosis and management , 2007, Current infectious disease reports.
[23] R. Boyle,et al. Hypoxia: targeting the tumour. , 2006, Anti-cancer agents in medicinal chemistry.
[24] A. Harris,et al. Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] T. Sauerbruch,et al. Neutropenic enterocolitis in adults: systematic analysis of evidence quality , 2005, European journal of haematology.
[26] Y. Pommier,et al. Topoisomerase I-Mediated Inhibition of Hypoxia-Inducible Factor 1 , 2004, Cancer Research.
[27] C. Lottaz,et al. Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF , 2004, Leukemia.
[28] S. Kaufmann,et al. Neutropenic colitis after treatment of acute myelogenous leukemia with idarubicin and cytosine arabinoside. , 2002, Mayo Clinic proceedings.
[29] P. Iversen,et al. Increased cellular hypoxia and reduced proliferation of both normal and leukaemic cells during progression of acute myeloid leukaemia in rats , 2000, Cell proliferation.
[30] D A Hilton,et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. , 1999, Cancer research.
[31] C. Coleman,et al. Phase I trial of the hypoxic cell cytotoxin tirapazamine with concurrent radiation therapy in the treatment of refractory solid tumors. , 1999, International journal of radiation oncology, biology, physics.
[32] Durand Re. The influence of microenvironmental factors during cancer therapy. , 1994 .
[33] R. Durand. The influence of microenvironmental factors during cancer therapy. , 1994, In vivo.
[34] L. H. Gray,et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. , 1953, The British journal of radiology.