β-Klotho gene variation is associated with liver damage in children with NAFLD.

[1]  Sophie A. Montandon,et al.  β-Klotho deficiency shifts the gut-liver bile acid axis and induces hepatic alterations in mice. , 2018, American journal of physiology. Endocrinology and metabolism.

[2]  M. Kuro-o The Klotho proteins in health and disease , 2018, Nature Reviews Nephrology.

[3]  J. Trotter,et al.  NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial , 2018, The Lancet.

[4]  Rohit Kohli,et al.  The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids , 2018, Hepatology.

[5]  E. Pardon,et al.  Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling , 2018, Nature.

[6]  Klaudia Walter,et al.  The impact of rare and low-frequency genetic variants in common disease , 2017, Genome Biology.

[7]  Stephen J. Bruce,et al.  β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. , 2017, JCI insight.

[8]  R. Urtasun,et al.  Fibroblast Growth Factor 15/19 in Hepatocarcinogenesis , 2017, Digestive Diseases.

[9]  P. Dawson,et al.  Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives , 2016, Hepatology.

[10]  Luca Valenti,et al.  Genetics of nonalcoholic fatty liver disease. , 2016, Metabolism: clinical and experimental.

[11]  L. Henry,et al.  Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in the United States and the Rest of the World. , 2016, Clinics in liver disease.

[12]  A. McCullough,et al.  Natural History of Nonalcoholic Fatty Liver Disease , 2016, Digestive Diseases and Sciences.

[13]  M. Trauner,et al.  Nuclear Receptor Modulation for the Treatment of Nonalcoholic Fatty Liver Disease , 2016, Seminars in Liver Disease.

[14]  H. Hermanns,et al.  Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease. , 2015, Cytokine & growth factor reviews.

[15]  H. Scharnagl,et al.  Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease , 2015, Journal of pediatric gastroenterology and nutrition.

[16]  S. Kliewer,et al.  Bile Acids as Hormones: The FXR-FGF15/19 Pathway , 2015, Digestive Diseases.

[17]  B. Neuschwander‐Tetri,et al.  Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial , 2015, The Lancet.

[18]  J. Borén,et al.  Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease , 2015, Hepatology.

[19]  M. Yeh,et al.  Pathological features of fatty liver disease. , 2014, Gastroenterology.

[20]  Anne Tybjærg-Hansen,et al.  Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease , 2014, Nature Genetics.

[21]  A. Alisi,et al.  Commentary: FGF21 holds promises for treating obesity-related insulin resistance and hepatosteatosis. , 2014, Endocrinology.

[22]  Q. Anstee,et al.  The genetics of NAFLD , 2013, Nature Reviews Gastroenterology &Hepatology.

[23]  H. Tilg,et al.  Non-alcoholic steatohepatitis: a microbiota-driven disease , 2013, Trends in Endocrinology & Metabolism.

[24]  G. Tarantino,et al.  What does irritable bowel syndrome share with non-alcoholic fatty liver disease? , 2013, World journal of gastroenterology.

[25]  G. Bedogni,et al.  Association between Serum Atypical Fibroblast Growth Factors 21 and 19 and Pediatric Nonalcoholic Fatty Liver Disease , 2013, PloS one.

[26]  G. Svegliati-Baroni,et al.  A 360-degree overview of paediatric NAFLD: recent insights. , 2013, Journal of hepatology.

[27]  P. Edwards,et al.  Pleiotropic roles of bile acids in metabolism. , 2013, Cell metabolism.

[28]  A. Zinsmeister,et al.  A Klothoβ variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea. , 2011, Gastroenterology.

[29]  M. Trauner,et al.  Nuclear receptors in liver disease , 2011, Hepatology.

[30]  N. Itoh,et al.  Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. , 2011, Journal of biochemistry.

[31]  O. Cummings,et al.  Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. , 2010, Gastroenterology.

[32]  A. Alisi,et al.  I148M patatin‐like phospholipase domain‐containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease , 2010, Hepatology.

[33]  N. Itoh Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease , 2010, Cell and Tissue Research.

[34]  J. Chiang,et al.  Bile acids: regulation of synthesis , 2009, Journal of Lipid Research.

[35]  M. Kuro-o,et al.  The Klotho gene family as a regulator of endocrine fibroblast growth factors , 2009, Molecular and Cellular Endocrinology.

[36]  Alexander Pertsemlidis,et al.  Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease , 2008, Nature Genetics.

[37]  M. Kuro-o Endocrine FGFs and Klothos: emerging concepts , 2008, Trends in Endocrinology & Metabolism.

[38]  S. Kliewer,et al.  Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21* , 2007, Journal of Biological Chemistry.

[39]  S. Kliewer,et al.  Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. , 2005, Cell metabolism.

[40]  S. Kliewer,et al.  Weaving βKlotho into bile acid metabolism , 2005 .

[41]  O. Cummings,et al.  Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.

[42]  Stephen J. Bruce,et al.  b-Klotho deficiency protects against obesity through a crosstalk between liver , microbiota , and brown adipose tissue , 2018 .

[43]  Chou-Long Huang Regulation of ion channels by secreted Klotho. , 2012, Advances in experimental medicine and biology.

[44]  M. Mohammadi,et al.  The structural biology of the FGF19 subfamily. , 2012, Advances in experimental medicine and biology.