Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

[1]  J. Buchner,et al.  The HSP90 chaperone machinery , 2017, Nature Reviews Molecular Cell Biology.

[2]  N. Tanaka,et al.  Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. , 2017, Biochemical and biophysical research communications.

[3]  Wei He,et al.  Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells. , 2016, International journal of oncology.

[4]  J. Yates,et al.  Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death , 2016, The Journal of cell biology.

[5]  Xiaoming Jiang,et al.  Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer , 2016, Autophagy.

[6]  A. Jemal,et al.  Cancer statistics, 2016 , 2016, CA: a cancer journal for clinicians.

[7]  Sen Zhang,et al.  Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways. , 2014, Current cancer drug targets.

[8]  F. Taylor,et al.  Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. , 2014, Biochemical pharmacology.

[9]  F. Beuschlein,et al.  Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells , 2013, International journal of oncology.

[10]  C. Young,et al.  Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells , 2013, Cell Death and Disease.

[11]  Chien-Feng Li,et al.  Autophagy is involved in endogenous and NVP-AUY922-induced KIT degradation in gastrointestinal stromal tumors , 2013, Autophagy.

[12]  T. Hughes,et al.  Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice. , 2013, Biochemical and biophysical research communications.

[13]  P. Filipcik,et al.  Intracellular degradation of misfolded tau protein induced by geldanamycin is associated with activation of proteasome. , 2012, Journal of Alzheimer's disease : JAD.

[14]  T. Saha LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy , 2012, Autophagy.

[15]  Qiuyun Liu,et al.  SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. , 2012, Cancer letters.

[16]  J. Tam,et al.  Role of Chaperone Mediated Autophagy (CMA) in the Degradation of Misfolded N-CoR Protein in Non-Small Cell Lung Cancer (NSCLC) Cells , 2011, PloS one.

[17]  T. Johansen,et al.  Following autophagy step by step , 2011, BMC Biology.

[18]  H. Friess,et al.  Insulin-like growth factor signaling as a therapeutic target in pancreatic cancer. , 2011, Anti-cancer agents in medicinal chemistry.

[19]  G. Giaccone,et al.  Heat Shock Protein 90-Sheltered Overexpression of Insulin-Like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors , 2011, Clinical Cancer Research.

[20]  Wenming Li,et al.  Chaperone-mediated autophagy: machinery, regulation and biological consequences , 2011, Cellular and Molecular Life Sciences.

[21]  A. Pandiella,et al.  Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis. , 2010, Leukemia research.

[22]  Tao Zhang,et al.  Withaferin A targets heat shock protein 90 in pancreatic cancer cells. , 2010, Biochemical pharmacology.

[23]  C. Richter-Landsberg,et al.  17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy , 2010, PloS one.

[24]  Y. Li,et al.  Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy , 2009, The Journal of cell biology.

[25]  T. Gasiewicz,et al.  (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor. , 2009, Biochemistry.

[26]  A. Cuervo,et al.  Methods to monitor chaperone-mediated autophagy. , 2009, Methods in enzymology.

[27]  Keiji Tanaka,et al.  Hsp90-mediated Assembly of the 26 S Proteasome Is Involved in Major Histocompatibility Complex Class I Antigen Processing* , 2008, Journal of Biological Chemistry.

[28]  W. Pratt,et al.  The Hsp90 Chaperone Machinery Regulates Signaling by Modulating Ligand Binding Clefts* , 2008, Journal of Biological Chemistry.

[29]  M. Pollak Targeting insulin and insulin-like growth factor signalling in oncology. , 2008, Current opinion in pharmacology.

[30]  A. Cuervo,et al.  The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane , 2008, Molecular and Cellular Biology.

[31]  F. Chang,et al.  Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins* , 2008, Journal of Biological Chemistry.

[32]  A. Cuervo,et al.  Chaperone-mediated autophagy. , 2008, Methods in molecular biology.

[33]  O. Stoeltzing,et al.  Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription 3/Hypoxia-Inducible Factor-1α Autocrine Loop, and Reduces Orthotopic Tumor Growth , 2007, Clinical Cancer Research.

[34]  D. Stolz,et al.  Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. , 2007, The American journal of pathology.

[35]  D. Rubinsztein,et al.  Potential therapeutic applications of autophagy , 2007, Nature Reviews Drug Discovery.

[36]  A. Cuervo,et al.  Consequences of the selective blockage of chaperone-mediated autophagy. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[37]  D. Klionsky,et al.  Autophagy: molecular machinery for self-eating , 2005, Cell Death and Differentiation.

[38]  Takeshi Tokuhisa,et al.  The role of autophagy during the early neonatal starvation period , 2004, Nature.

[39]  J. Dice,et al.  Mechanisms of chaperone-mediated autophagy. , 2004, The international journal of biochemistry & cell biology.

[40]  A. Cuervo,et al.  Activation of chaperone-mediated autophagy during oxidative stress. , 2004, Molecular biology of the cell.

[41]  Daniel J Klionsky,et al.  Development by self-digestion: molecular mechanisms and biological functions of autophagy. , 2004, Developmental cell.

[42]  K. Prasad,et al.  Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability. , 2004, Cancer letters.

[43]  L. Neckers,et al.  Heat shock protein 90 as a molecular target for cancer therapeutics. , 2003, Cancer cell.

[44]  G. Mills,et al.  Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. , 2002, Molecular cancer therapeutics.

[45]  C. Sawyers,et al.  The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.

[46]  G. M. Di Guglielmo,et al.  Inhibition of Endosomal Insulin-like Growth Factor-I Processing by Cysteine Proteinase Inhibitors Blocks Receptor-mediated Functions* , 2001, The Journal of Biological Chemistry.

[47]  David M. Smith,et al.  Ester Bond-containing Tea Polyphenols Potently Inhibit Proteasome Activity in Vitro and in Vivo * , 2001, The Journal of Biological Chemistry.

[48]  Takeshi Noda,et al.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.

[49]  A. Klippel,et al.  Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt , 1997, Molecular and cellular biology.

[50]  M. Korc,et al.  Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. , 1995, Cancer research.

[51]  C T Roberts,et al.  Molecular and cellular aspects of the insulin-like growth factor I receptor. , 1995, Endocrine reviews.

[52]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[53]  J. Dice,et al.  Peptide sequences that target proteins for enhanced degradation during serum withdrawal. , 1988, The Journal of biological chemistry.

[54]  C Collins,et al.  Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. , 1986, The EMBO journal.