Interstitial pneumonitis after total body irradiation: effect of partial lung shielding

The potential beneficial effects of partial lung shielding were investigated in 44 patients conditioned by whole body radiotherapy as part of the conditioning for bone marrow transplantation (BMT). The first 23 patients were irradiated with fractionated total body irradiation (TBI) to a total dose of 12 Gy. In the second series of 21 patients a 50% transmission lung shield was utilized following 6 Gy TBI. This treatment was combined in the second group with four fractions of 1.5 Gy total lymphoid irradiation (TLI), given in 2 d. The rate of idiopathic interstitial pneumonitis (IP) was 26% in the first group, compared to none in the second.

[1]  U. Quast.  Total body irradiation—review of treatment techniquesin Europe , 1987 .

[2]  U. Quast.  Total body irradiation--review of treatment techniques in Europe. , 1987, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[3]  D. Engelhard,et al.  New approaches for the prevention of rejection and graft-vs.-host disease in clinical bone marrow transplantation. , 1986, Israel journal of medical sciences.

[4]  Z. Fuks,et al.  The use of total lymphoid irradiation for allogeneic bone marrow transplantation in animals and man , 1985, Survey of immunologic research.

[5]  G. Hale,et al.  ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1) , 1984, The Lancet.

[6]  R. Evans.  Radiobiological considerations in magna-field irradiation. , 1983, International journal of radiation oncology, biology, physics.

[7]  E. D. Tomas.  [Bone marrow transplantation in leukemia]. , 1983, Terapevticheskii arkhiv.

[8]  R. Storb,et al.  Marrow transplantation for acute nonlymphoblastic leukemic in first remission using fractionated or single-dose irradiation. , 1982, International journal of radiation oncology, biology, physics.

[9]  F. Khan,et al.  Radiobiological basis of total body irradiation with different dose rate and fractionation: repair capacity of hemopoietic cells. , 1981, International journal of radiation oncology, biology, physics.

[10]  J. Van Dyk,et al.  Idiopathic interstitial pneumonia following bone marrow transplantation: the relationship with total body irradiation. , 1981, International journal of radiation oncology, biology, physics.

[11]  P. Neiman,et al.  Marrow transplantation for acute nonlymphoblastic leukemia in first remission. , 1979, The New England journal of medicine.

[12]  S. Strober,et al.  Induction of allograft tolerance after total lymphoid irradiation (TLI): development of suppressor cells of the mixed leukocyte reaction (MLR). , 1979, Journal of immunology.

[13]  H. Withers,et al.  Radiobiological considerations in the use of total-body irradiation for bone-marrow transplantation. , 1979, Radiology.

[14]  P. Fitzpatrick,et al.  Radiation pneumonitis: experience following a large single dose of radiation. , 1978, International journal of radiation oncology, biology, physics.

[15]  B. Kavanagh.  Radiobiological considerations , 1977, Annals of the ICRP.

[16]  Z. Fuks,et al.  Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts , 1977, The Journal of experimental medicine.

[17]  R. Storb,et al.  Total-body irradiation in preparation for marrow engraftment. , 1976, Transplantation proceedings.

[18]  J. Boyd,et al.  The treatment of Hodgkin's disease. , 1966, Guy's Hospital reports.

[19]  J. McPhee,et al.  Pneumonitis following radiation therapy of cancer of the breast by tangenital technic. , 1955, Radiology.

[20]  Franz Wohlauer.  Der Einfluß der Röntgenstrahlen auf das Lungengewebe , 1909 .