Recent advances from the National Cancer Institute Alliance for Nanotechnology in Cancer.

Nanotechnology will have great impact on how cancer is diagnosed and treated in the future. New technologies to detect and image cancerous changes and materials that enable new methods of cancer treatment will radically alter patient outcomes. The National Cancer Institute (NCI) Alliance for Nanotechnology in Cancer sponsors research in cancer prevention, diagnosis, and therapy and promotes translation of basic science discoveries into clinical practice. The Fourth Annual NCI Alliance Principal Investigator Meeting was held in Manhattan Beach, California October 20-22, 2009. Presented here are highlights from the research presentations at the meeting, in the areas of in vitro diagnostics, targeted delivery of anticancer and contrast enhancement agents, and nanotherapeutics and therapeutic monitoring.

[1]  L. Hood,et al.  Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood , 2008, Nature Biotechnology.

[2]  Mark E. Davis,et al.  Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles. , 2007, Bioconjugate chemistry.

[3]  Roger Y Tsien,et al.  In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. , 2009, Integrative biology : quantitative biosciences from nano to macro.

[4]  T. Odom,et al.  Selective functionalization and spectral identification of gold nanopyramids , 2007 .

[5]  L. Tanoue,et al.  Detection of Mutations in EGFR in Circulating Lung-Cancer Cells , 2010 .

[6]  Roger Y Tsien,et al.  Tumor imaging by means of proteolytic activation of cell-penetrating peptides. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Shiladitya Sengupta,et al.  Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system , 2005, Nature.

[8]  Jeunghoon Lee,et al.  Tailoring the structure of nanopyramids for optimal heat generation. , 2009, Nano letters.

[9]  Erkki Ruoslahti,et al.  Tissue-penetrating delivery of compounds and nanoparticles into tumors. , 2009, Cancer cell.

[10]  T. Odom,et al.  Pyramids: a platform for designing multifunctional plasmonic particles. , 2008, Accounts of chemical research.

[11]  S. Digumarthy,et al.  Isolation of rare circulating tumour cells in cancer patients by microchip technology , 2007, Nature.

[12]  Gabriel A Kwong,et al.  Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells. , 2009, Journal of the American Chemical Society.

[13]  Gabriel A Kwong,et al.  DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins. , 2007, Journal of the American Chemical Society.

[14]  S. Bhatia,et al.  Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging , 2008, Advanced materials.

[15]  M. Ferrari.  Cancer nanotechnology: opportunities and challenges , 2005, Nature Reviews Cancer.

[16]  Tayyaba Hasan,et al.  In vivo Optical Molecular Imaging of Vascular Endothelial Growth Factor for Monitoring Cancer Treatment , 2008, Clinical Cancer Research.

[17]  E. Ruoslahti,et al.  C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration , 2009, Proceedings of the National Academy of Sciences.