A Hard Wired Model of Coupled Frontal Working memories for various Tasks

Abstract The majority of previous models of working memory (WM), rule production and strategy decisions have not taken into account the known anatomy of the human brain. Here, a simple hard wired neural network is developed which investigates the role of the dorsolateral prefrontal cortex (DLPFC), the ventrolateral pretroutal cortex (VL) and the Anterior Cingulate Gyrus (ACG), together with their associated basal ganglia-thalamocortical loops, in solving the classical delayed response task (DRS). Delayed visual matching (DRO) and the Wisconsin card sorting task (WCST). This is done by constraining the model by some of the known connectivity within these areas. Lesions are also applied to the model thereby providing possible interpretations for some of the deficits observed in various kinds of patients while performing those tasks.

[1]  G. E. Alexander,et al.  Functional architecture of basal ganglia circuits: neural substrates of parallel processing , 1990, Trends in Neurosciences.

[2]  Joel L. Davis,et al.  Adaptive Critics and the Basal Ganglia , 1995 .

[3]  R. Berndt,et al.  Neural Modeling of Brain and Cognitive Disorders , 1996 .

[4]  A. Benton,et al.  Frontal Lobe Function and Dysfunction , 1991 .

[5]  Garrett E. Alexander.  Basal ganglia , 1998 .

[6]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.

[7]  Edward E. Smith,et al.  Temporal dynamics of brain activation during a working memory task , 1997, Nature.

[8]  M. Petrides.  Comparative architectonic analysis of the human and the macaque frontal cortex , 1994 .

[9]  D. Joel,et al.  The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia , 1995, Behavioural Brain Research.

[10]  M. Raichle,et al.  The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[11]  M. Farah,et al.  A unified account of cognitive impairments following frontal lobe damage: the role of working memory in complex, organized behavior. , 1993, Journal of experimental psychology. General.

[12]  D. Weinberger,et al.  Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specificity. , 1988, Archives of general psychiatry.

[13]  J. Deniau,et al.  Disinhibition as a basic process in the expression of striatal functions , 1990, Trends in Neurosciences.

[14]  D. Zipser,et al.  A spiking network model of short-term active memory , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[15]  D. Weinberger,et al.  Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism. , 1988, Archives of general psychiatry.

[16]  Richard Coppola,et al.  Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study , 1995, Neuropsychologia.

[17]  Scott T. Grafton,et al.  Pallidotomy increases activity of motor association cortex in parkinson's disease: A positron emission tomographic study , 1995, Annals of neurology.

[18]  Kenji Doya,et al.  Reinforcement learning with multiple representations in the basal ganglia loops for sequential motor control , 1998, 1998 IEEE International Joint Conference on Neural Networks Proceedings. IEEE World Congress on Computational Intelligence (Cat. No.98CH36227).

[19]  ChrisD . Frith.  The Cognitive Neuropsychology of Schizophrenia , 1992 .

[20]  P. Goldman-Rakic,et al.  Dissociation of object and spatial processing domains in primate prefrontal cortex. , 1993, Science.

[21]  Jose L. Contreras-Vidal,et al.  A NEURAL NETWORK MODEL OF MOVEMENT PRODUCTION IN PARKINSON'S DISEASE AND HUNTINGTON'S DISEASE , 1996 .

[22]  Peter Ford Dominey,et al.  A Model of Corticostriatal Plasticity for Learning Oculomotor Associations and Sequences , 1995, Journal of Cognitive Neuroscience.

[23]  Alan C. Evans,et al.  Planning and Spatial Working Memory: a Positron Emission Tomography Study in Humans , 1996, The European journal of neuroscience.

[24]  C. Gerfen,et al.  The frontal cortex-basal ganglia system in primates. , 1996, Critical reviews in neurobiology.

[25]  F. Plum.  Handbook of Physiology. , 1960 .

[26]  P. Strick,et al.  Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. , 1994, Science.

[27]  R. O’Reilly,et al.  A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[28]  Adele Diamond,et al.  Guidelines for the study of brain-behavior relationships during development. , 1991 .

[29]  R. J. Dolan,et al.  Differential neural response to positive and negative feedback in planning and guessing tasks , 1997, Neuropsychologia.

[30]  Okihide Hikosaka,et al.  Role of basal ganglia in initiation of voluntary movements , 1988 .

[31]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.

[32]  P. Goldman-Rakic,et al.  Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[33]  Oury Monchi,et al.  Computational Neuroscience Models to Complement Brain Imaging Data for the Understanding of Working Memory Processes , 1998, NeuroImage.

[34]  John G. Taylor,et al.  Models of Coupled Anterior Working Memories for Frontal Tasks , 1997, NCPW.

[35]  Bernard Pillon,et al.  Cognitive deficits in Parkinson’s disease , 1996, Journal of Neurology.

[36]  Frank Roels,et al.  Autoradiographic localization of D1 and D2 dopamine receptors in the human brain , 1988, Neuroscience Letters.

[37]  J. Saint-Cyr,et al.  Frontal lobe dysfunction in Parkinson's disease. The cortical focus of neostriatal outflow. , 1986, Brain : a journal of neurology.

[38]  Patricia S. Goldman-Rakic,et al.  Toward a circuit model of working memory and the guidance of voluntary motor action , 1995 .

[39]  Daniel S. Levine,et al.  Modeling some effects of frontal lobe damage--Novelty and perseveration , 1989, Neural Networks.

[40]  D. Weinberger.  Implications of normal brain development for the pathogenesis of schizophrenia. , 1987, Archives of general psychiatry.

[41]  Jordan Grafman,et al.  Handbook of Neuropsychology , 1991 .