Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF.
暂无分享,去创建一个
[1] C. Schmitt,et al. Oncogene-induced senescence: putting the brakes on tumor development. , 2006, Cancer research.
[2] R. Deberardinis,et al. Autophagy in metazoans: cell survival in the land of plenty , 2005, Nature Reviews Molecular Cell Biology.
[3] C. Springer,et al. V599EB-RAF is an Oncogene in Melanocytes , 2004, Cancer Research.
[4] E. Morselli,et al. Life, death and burial: multifaceted impact of autophagy. , 2008, Biochemical Society transactions.
[5] G. Evan,et al. Distinct thresholds govern Myc's biological output in vivo. , 2008, Cancer cell.
[6] Michael R. Green,et al. Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7 , 2008, Cell.
[7] P. Uribe,et al. Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi. , 2006, The Journal of investigative dermatology.
[8] S. Levison,et al. Neural Stem Cells in the Subventricular Zone are Resilient to Hypoxia/Ischemia whereas Progenitors are Vulnerable , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[9] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[10] Soldano Ferrone,et al. Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity. , 2006, Cancer research.
[11] M. Jäättelä,et al. Autophagy: An emerging target for cancer therapy , 2008, Autophagy.
[12] P. Sutphin,et al. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. , 2008, Cancer cell.
[13] David P. Davis,et al. Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. , 2006, Cancer research.
[14] E. Morselli,et al. Control of autophagy by oncogenes and tumor suppressor genes , 2009, Cell Death and Differentiation.
[15] R L Kassel,et al. An endotoxin-induced serum factor that causes necrosis of tumors. , 1975, Proceedings of the National Academy of Sciences of the United States of America.
[16] Yonghong Xiao,et al. GOLPH3 modulates mTOR signaling and rapamycin sensitivity in cancer , 2009, Nature.
[17] P. Codogno,et al. Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells* , 2000, The Journal of Biological Chemistry.
[18] L. Zon,et al. BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma , 2005, Current Biology.
[19] Lewis A. Chodosh,et al. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis , 2007, Nature Cell Biology.
[20] D. Tuveson,et al. C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). , 2009, Molecular cell.
[21] Baolin Wu,et al. Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. , 2008, Cancer cell.
[22] M. Gordon. In Melanoma, RAS Mutations Are Accompanied by Switching Signaling from BRAF to CRAF and Disrupted Cyclic AMP Signaling , 2008 .
[23] W. White,et al. Expression of microtubule-associated protein 2 in benign and malignant melanocytes: implications for differentiation and progression of cutaneous melanoma. , 2001, The American journal of pathology.
[24] F. Lozupone,et al. Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma , 2006, Oncogene.
[25] Takeshi Noda,et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.
[26] Timothy Cash,et al. Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent* , 2004, Journal of Biological Chemistry.
[27] D. Peeper,et al. Cellular senescence in vivo: a barrier to tumorigenesis. , 2008, Current opinion in cell biology.
[28] M. Serrano,et al. A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. , 2007, Genes & development.
[29] Joseph Avruch,et al. Rheb Binds and Regulates the mTOR Kinase , 2005, Current Biology.
[30] S. Pattingre,et al. Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells* , 2003, The Journal of Biological Chemistry.
[31] Govind Bhagat,et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. , 2003, The Journal of clinical investigation.
[32] Gerard Manning,et al. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. , 2009, Cancer research.
[33] S. Lowe,et al. Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.
[34] C. Johannessen,et al. A negative feedback signaling network underlies oncogene-induced senescence. , 2006, Cancer cell.
[35] J. J. van den Oord,et al. Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma. , 2001, The Journal of investigative dermatology.
[36] J. Shay,et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi , 2005, Nature.
[37] S. Furuta,et al. Ras is involved in the negative control of autophagy through the class I PI3-kinase , 2004, Oncogene.
[38] T. Pier,et al. Protein Expression of Matriptase and its Cognate Inhibitor HAI-1 in Human Prostate Cancer: A Tissue Microarray and Automated Quantitative Analysis , 2009, Applied immunohistochemistry & molecular morphology : AIMM.
[39] M. Ratain,et al. Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis , 2006, British Journal of Cancer.
[40] Todd R. Golub,et al. BRAF mutation predicts sensitivity to MEK inhibition , 2006, Nature.
[41] K. Guan,et al. Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? , 2006, Oncogene.
[42] Hong Wu,et al. mTOR is activated in the majority of malignant melanomas. , 2008, The Journal of investigative dermatology.