Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection

Diagnosis of EBV-driven T/NK-cell lymphoproliferative disorders and chronic active EBV diseases is often difficult. Fournier et al. report a flow-FISH cytometry assay allowing rapid identification of EBV-infected cells in blood and accurate diagnoses. It represents a powerful tool to study pathophysiological mechanisms of EBV-LPD.

[1]  Smita Y. Patel,et al.  Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation. , 2020, JCI insight.

[2]  S. Hue,et al.  Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach. , 2019, Pathology.

[3]  A. Fischer,et al.  Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells , 2019, The Journal of experimental medicine.

[4]  A. Fischer,et al.  Signaling pathways involved in the T‐cell‐mediated immunity against Epstein‐Barr virus: Lessons from genetic diseases , 2019, Immunological reviews.

[5]  S. Tsao,et al.  Epstein–Barr virus ncRNA from a nasopharyngeal carcinoma induces an inflammatory response that promotes virus production , 2019, Nature Microbiology.

[6]  F. Collins,et al.  Hydroa vacciniforme-like lymphoproliferative disorder: an EBV disease with a low risk of systemic illness in Caucasians. , 2019, Blood.

[7]  Jiali Cheng,et al.  Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases , 2019, Open forum infectious diseases.

[8]  L. Quintanilla‐Martinez,et al.  Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases , 2019, Front. Pediatr..

[9]  Y. Kwong,et al.  EBV Viral Loads in Diagnosis, Monitoring, and Response Assessment , 2019, Front. Oncol..

[10]  A. Arai.  Advances in the Study of Chronic Active Epstein-Barr Virus Infection: Clinical Features Under the 2016 WHO Classification and Mechanisms of Development , 2019, Front. Pediatr..

[11]  Masahiro Yoshida,et al.  Defective Epstein–Barr virus in chronic active infection and haematological malignancy , 2019, Nature Microbiology.

[12]  M. Inoue,et al.  Hematopoietic Stem Cell Transplantation for the Treatment of Epstein-Barr Virus-Associated T- or NK-Cell Lymphoproliferative Diseases and Associated Disorders , 2018, Front. Pediatr..

[13]  C. Bollard,et al.  How I treat T-cell chronic active Epstein-Barr virus disease. , 2018, Blood.

[14]  S. Latour,et al.  Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases , 2018, Front. Immunol..

[15]  D. Heo,et al.  CD21-independent Epstein-Barr virus entry into NK cells. , 2018, Cellular immunology.

[16]  Y. Oki,et al.  Novel Immunotherapy Options for Extranodal NK/T-Cell Lymphoma , 2018, Front. Oncol..

[17]  H. Tagawa,et al.  A distinct subtype of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features , 2017, Haematologica.

[18]  J. Todd,et al.  Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2 , 2017, JCI insight.

[19]  Robert E. White,et al.  Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression. , 2017, Cell host & microbe.

[20]  K. Kawa,et al.  How we treat chronic active Epstein–Barr virus infection , 2017, International Journal of Hematology.

[21]  S. Tangye,et al.  Human immunity against EBV—lessons from the clinic , 2017, The Journal of experimental medicine.

[22]  A. Fischer,et al.  Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection , 2017, The Journal of experimental medicine.

[23]  C. Rongyi,et al.  Hydroa vacciniforme-like lymphoma , 2016, QJM : monthly journal of the Association of Physicians.

[24]  M. Plummer,et al.  Global burden of cancers attributable to infections in 2012: a synthetic analysis. , 2016, The Lancet. Global health.

[25]  B. McFarlin,et al.  Measurement of Low‐Abundance Intracellular mRNA Using Amplified FISH Staining and Image‐Based Flow Cytometry , 2016, Current protocols in cytometry.

[26]  Sin-Ho Jung,et al.  A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis. , 2016, The Lancet. Oncology.

[27]  Thierry Fest,et al.  GenomicScape: An Easy-to-Use Web Tool for Gene Expression Data Analysis. Application to Investigate the Molecular Events in the Differentiation of B Cells into Plasma Cells , 2015, PLoS Comput. Biol..

[28]  M. Rowe,et al.  Unexpected patterns of Epstein–Barr virus transcription revealed by a High throughput PCR array for absolute quantification of viral mRNA , 2015, Virology.

[29]  A. Fischer,et al.  CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation , 2014, Nature.

[30]  T. Murata,et al.  Role of latent membrane protein 1 in chronic active Epstein–Barr virus infection-derived T/NK-cell proliferation , 2014, Cancer medicine.

[31]  L. Quintanilla‐Martinez,et al.  Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma. , 2013, Blood.

[32]  S. Tracy,et al.  The pathogenesis of Epstein-Barr virus persistent infection. , 2013, Current opinion in virology.

[33]  T. Kinoshita,et al.  Application of flow cytometric in situ hybridization assay to Epstein–Barr virus‐associated T/natural killer cell lymphoproliferative diseases , 2012, Cancer science.

[34]  T. Naoe,et al.  EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. , 2012, Blood.

[35]  D. Douek,et al.  Second messenger role for Mg2+ revealed by human T-cell immunodeficiency , 2011, Nature.

[36]  T. Cenci,et al.  The Viral Load of Epstein–Barr Virus (EBV) DNA in Peripheral Blood Predicts for Biological and Clinical Characteristics in Hodgkin Lymphoma , 2011, Clinical Cancer Research.

[37]  Y. Yamauchi,et al.  Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases. , 2009, The Journal of infectious diseases.

[38]  S. Tangye,et al.  Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients. , 2008, Blood.

[39]  T. Greenough,et al.  On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. , 2008, Blood.

[40]  Mark Ende,et al.  Hematopoietic stem-cell transplantation. , 2006, The New England journal of medicine.

[41]  S. Pittaluga,et al.  Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease. , 2006, The Journal of clinical investigation.

[42]  Richard C Brundage,et al.  A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis. , 2005, The Journal of infectious diseases.

[43]  T. Pawson,et al.  The Epstein-Barr Virus Protein, Latent Membrane Protein 2A, Co-opts Tyrosine Kinases Used by the T Cell Receptor* , 2005, Journal of Biological Chemistry.

[44]  L. Young,et al.  Epstein–Barr virus: 40 years on , 2004, Nature Reviews Cancer.

[45]  M. Gulley,et al.  Epstein-Barr Virus (EBV) DNA in Plasma Is Not Encapsidated in Patients With EBV-Related Malignancies , 2004, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[46]  D. Thorley-Lawson,et al.  Acute Infection with Epstein-Barr Virus Targets and Overwhelms the Peripheral Memory B-Cell Compartment with Resting, Latently Infected Cells , 2004, Journal of Virology.

[47]  E. Joly,et al.  What is trogocytosis and what is its purpose? , 2003, Nature Immunology.

[48]  P. Brousset,et al.  Acquisition of Viral Receptor by NK Cells Through Immunological Synapse1 , 2003, The Journal of Immunology.

[49]  R. Freeman,et al.  The dispersal of mucosal memory B cells: evidence from persistent EBV infection. , 2002, Immunity.

[50]  W. Hammerschmidt,et al.  The Epstein–Barr virus lytic program is controlled by the co‐operative functions of two transactivators , 2000, The EMBO journal.

[51]  D. Thorley-Lawson,et al.  A model for persistent infection with Epstein-Barr virus: the stealth virus of human B cells. , 1999, Life sciences.

[52]  R. Freeman,et al.  Epstein-Barr Virus–Infected Resting Memory B Cells, Not Proliferating Lymphoblasts, Accumulate in the Peripheral Blood of Immunosuppressed Patients , 1999, The Journal of experimental medicine.

[53]  L. Kunz-Schughart,et al.  Epstein-Barr Virus Small RNA (EBER) Genes: Differential Regulation during Lytic Viral Replication , 1998, Journal of Virology.

[54]  W. Hammerschmidt,et al.  Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[55]  J. Chan,et al.  Clarification of CD3 immunoreactivity in nasal T/natural killer cell lymphomas: the neoplastic cells are often CD3 epsilon+. , 1996, Blood.

[56]  U. Nater,et al.  Epstein-Barr virus. , 1991, The Journal of family practice.

[57]  L. Resnick,et al.  Epstein-Barr virus small nuclear RNAs are not expressed in permissively infected cells in AIDS-associated leukoplakia. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[58]  J. Steitz,et al.  Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[59]  R. Feederle,et al.  Epstein-Barr Virus: From the Detection of Sequence Polymorphisms to the Recognition of Viral Types. , 2015, Current topics in microbiology and immunology.

[60]  R. Advani,et al.  The World Health Organization Classification of Lymphoid Neoplasms , 2013 .

[61]  Y. Nishiyama,et al.  Quantitative analysis of Epstein-Barr virus (EBV)-related gene expression in patients with chronic active EBV infection. , 2010, The Journal of general virology.