Preclinical activity of LBH 589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia
暂无分享,去创建一个
J. Cigudosa | J. Martinez-Climent | F. Prósper | J. Martín-Subero | M. Calasanz | X. Agirre | J. Ribera | G. Abizanda | A. Vilas-Zornoza | L. Gárate | J. Rifón | J. Román-Gómez | E. S. José-Enériz | C. Moreno | M. Blanco-Prieto | P. Río | E. Miranda | Victor | Segura | A. D. M. Rodríguez | Jose A. García de | Jalón | Cristina Moreno | A. Rodriguez | J. Román-Gómez
[1] J. Minna,et al. ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia , 2013, Oncogene.
[2] J. Martinez-Climent,et al. Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma. , 2010, Blood.
[3] A. Hall,et al. NFkappaB modulators in a model of glucocorticoid resistant, childhood acute lymphoblastic leukemia. , 2010, Leukemia research.
[4] A. Statnikov,et al. The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia. , 2010, Cancer cell.
[5] T. Holyoake,et al. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. , 2010, Cancer cell.
[6] S. Richards,et al. Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial. , 2010, The Lancet. Oncology.
[7] P. Atadja,et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma , 2010, Haematologica.
[8] Yiguo Jiang,et al. MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.
[9] G. Garcia-Manero,et al. Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. , 2010, Blood.
[10] M. Dobbelstein,et al. E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis , 2010, Cell Death and Differentiation.
[11] J. Esteve,et al. Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial , 2010, Haematologica.
[12] Peter A. Jones,et al. Epigenetics in cancer. , 2010, Carcinogenesis.
[13] Susan Groshen,et al. DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines , 2009, BMC Medical Genomics.
[14] C. Pui. Toward a total cure for acute lymphoblastic leukemia. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[15] Qiang Yu,et al. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. , 2009, Genes & development.
[16] J. Fletcher,et al. Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. , 2009, Cancer research.
[17] P. Atadja,et al. The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines , 2009, The Journal of pathology.
[18] J. Martinez-Climent,et al. Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia. , 2009, European journal of cancer.
[19] S. Bates,et al. Epigenetic Modifiers: Basic Understanding and Clinical Development , 2009, Clinical Cancer Research.
[20] R. Johnstone,et al. Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors. , 2009, Future oncology.
[21] R. Siebert,et al. Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. , 2009, Cancer research.
[22] R. Crazzolara,et al. Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. , 2009, Blood.
[23] C. Richard,et al. Successful induction therapy with decitabine in refractory childhood acute lymphoblastic leukemia , 2009, Leukemia.
[24] R. Siebert,et al. Epigenetic regulation of microRNAs in acute lymphoblastic leukemia. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] H. Kantarjian,et al. Epigenetics of acute lymphocytic leukemia. , 2009, Seminars in hematology.
[26] Iannis Aifantis,et al. γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia , 2009, Nature Medicine.
[27] A. Younes. Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma. , 2009, Hematology. American Society of Hematology. Education Program.
[28] G. Garcia-Manero. Demethylating agents in myeloid malignancies , 2008, Current opinion in oncology.
[29] A. Rossi,et al. The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer. , 2008, Critical reviews in oncology/hematology.
[30] L. Poling,et al. Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage , 2008, Pigment cell & melanoma research.
[31] J. Sarkaria,et al. Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. , 2008, Neuro-oncology.
[32] Leslie L Robison,et al. Acute lymphoblastic leukaemia , 2018, Radiopaedia.org.
[33] Terence P. Speed,et al. Estimation and assessment of raw copy numbers at the single locus level , 2008, Bioinform..
[34] S. Harrison,et al. The potential of histone deacetylase inhibitors for the treatment of multiple myeloma , 2008, Leukemia & lymphoma.
[35] P. Atadja,et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. , 2007, Blood.
[36] J. Issa,et al. Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia , 2008, Leukemia.
[37] F. Prósper,et al. Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. , 2007, Blood.
[38] J. Davis. Bioinformatics and Computational Biology Solutions Using R and Bioconductor , 2007 .
[39] Juan F. García,et al. Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. , 2007, Blood.
[40] P. Atadja,et al. Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells. , 2006, Blood.
[41] R. Siebert,et al. Partial uniparental disomy: a recurrent genetic mechanism alternative to chromosomal deletion in malignant lymphoma , 2006, Leukemia.
[42] Z. Szallasi,et al. Reliability and reproducibility issues in DNA microarray measurements. , 2006, Trends in genetics : TIG.
[43] H. G. Einsiedel,et al. Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia , 2006, Leukemia.
[44] S. Armstrong,et al. Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. , 2005, Blood.
[45] J. Hayes,et al. Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair. , 2005, Molecular cell.
[46] H. Koeffler,et al. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. , 2005, Experimental hematology.
[47] R. Lock,et al. Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. , 2004, Blood.
[48] Gordon K Smyth,et al. Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .
[49] K. Becker,et al. Analysis of microarray data using Z score transformation. , 2003, The Journal of molecular diagnostics : JMD.
[50] Rafael A Irizarry,et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.