Differences in MDS‐UPDRS Scores Based on Hoehn and Yahr Stage and Disease Duration

The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) is a newly developed tool to assess Parkinson's disease (PD). Changes in scores on the scale over the course of PD, including increasing disease duration and Hoehn and Yahr (HY) stages, have not been described. The objectives of this study were to analyze MDS‐UPDRS scores on Parts I through IV and their differences based on HY stage and disease duration in a large cohort of patients with PD.

Carmen Rodriguez-Blazquez | Pablo Martinez-Martin | Thomas Foltynie | Anette Schrag | Klaus Seppi | Werner Poewe | Eva Reiter | David A Gallagher | Pille Taba | Amin Cervantes-Arriaga | Jean-Christophe Corvol | Barbara C Tilley | Graziella Mangone | W. Poewe | G. Stebbins | T. Foltynie | C. Singer | C. Goetz | B. Tilley | P. Martínez-Martín | A. Schrag | J. Corvol | K. Seppi | M. Kurtis | O. Levin | C. Rodríguez-Blázquez | P. Taba | J. C. Martínez‐Castrillo | N. Kovács | I. Avilés-Olmos | L. Kadastik-Eerme | O. Gershanik | V. Datieva | M. Alvarez-Sanchez | T. Arakaki | A. Bergareche-Yarza | A. Chade | N. Garretto | A. Mendoza-Rodríguez | H. Moore | M. Rodríguez-Violante | Jing Huang | P. Valkovič | A. Cervantes-Arriaga | G. Mangone | E. Reiter | B. Pinter | C. Mueller | Christopher G Goetz | Iciar Aviles-Olmos | M. Skorvanek | Carlos Singer | Oscar Gershanik | Glenn T Stebbins | Norbert Kovacs | Christoph Mueller | Bernadette Pinter | Mario Alvarez-Sanchez | Tomoko Arakaki | Alberto Bergareche-Yarza | Anabel Chade | Nelida Garretto | Amelia Mendoza-Rodriguez | Mayela Rodriguez-Violante | Jing Huang | Matej Skorvanek | Oleg Levin | Zsuzsanna Aschermann | Eve Benchetrit | Charline Benoit | Florence Cormier | Veronika Datieva | Zuzana Gdovinova | Milan Grofik | Vladimir Han | Liis Kadastik-Eerme | Monica M Kurtis | Juan Carlos Martinez-Castrillo | Michal Minar | Henry P Moore | Mari Muldmaa | Karin Rallmann | Peter Valkovic | Z. Gdovinová | Z. Aschermann | M. Minár | M. Grofik | V. Han | D. Gallagher | Eve Benchetrit | Charline Benoit | F. Cormier | M. Muldmaa | Karin Rallmann | M. Škorvánek | M. Rodríguez‐Violante | Bernadette Pinter | Christoph Mueller | J. Martínez-Castrillo | E. Benchetrit | Anabel R. Chade | Henry P. Moore | Alberto Bergareche-Yarza | K. Rallmann | Florence Cormier

[1]  M. Hoehn,et al.  Parkinsonism , 1967, Neurology.

[2]  S. Fahn.  Members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale , 1987 .

[3]  N. Reynolds,et al.  Factor analysis of Parkinson's impairment. An evaluation of the final common pathway. , 1987, Archives of neurology.

[4]  J. Hughes,et al.  Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[5]  R. Fitzpatrick,et al.  The Parkinson's Disease Questionnaire (PDQ-39): development and validation of a Parkinson's disease summary index score. , 1997, Age and ageing.

[6]  A. Bonnet.  [The Unified Parkinson's Disease Rating Scale]. , 2000, Revue neurologique.

[7]  J. Unterrainer,et al.  Measuring the progression of idiopathic Parkinson's disease with [123I] β-CIT SPECT , 2000, Journal of Neural Transmission.

[8]  The Unified Parkinson's Disease Rating Scale (UPDRS): Status and recommendations , 2003, Movement disorders : official journal of the Movement Disorder Society.

[9]  W. Poewe,et al.  Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: Status and recommendations The Movement Disorder Society Task Force on rating scales for Parkinson's disease , 2004, Movement disorders : official journal of the Movement Disorder Society.

[10]  M. Hely,et al.  Sydney multicenter study of Parkinson's disease: Non‐L‐dopa–responsive problems dominate at 15 years , 2005, Movement disorders : official journal of the Movement Disorder Society.

[11]  W. Poewe,et al.  The natural history of parkinson's disease , 1998, Journal of neurology.

[12]  J. Jankovic,et al.  Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results , 2008, Movement disorders : official journal of the Movement Disorder Society.

[13]  C. Clarke,et al.  Systematic review of levodopa dose equivalency reporting in Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[14]  G. Stebbins,et al.  Expanded and independent validation of the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) , 2012, Journal of Neurology.

[15]  A. Albanese,et al.  Relationships between disability, quality of life and prevalence of nonmotor symptoms in Parkinson's disease. , 2012, Parkinsonism & related disorders.

[16]  P. Klivényi,et al.  [VALIDATION OF THE HUNGARIAN MDS-UPDRS: WHY DO WE NEED A NEW PARKINSON SCALE?]. , 2014, Ideggyogyaszati szemle.

[17]  A. Tóth,et al.  AZ MDS-UPDRS MAGYAR VALIDÁCIÓJA: MIÉRT SZÜKSÉGES ÚJABB PARKINSON-PONTOZÓSKÁLA? , 2014 .

[18]  Norbert Kovács,et al.  Minimal clinically important difference on the Motor Examination part of MDS-UPDRS. , 2015, Parkinsonism & related disorders.

[19]  K. Chaudhuri,et al.  The burden of non-motor symptoms in Parkinson's disease using a self-completed non-motor questionnaire: a simple grading system. , 2015, Parkinsonism & related disorders.

[20]  E. Tolosa,et al.  The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PD Study) , 2015, Movement disorders : official journal of the Movement Disorder Society.

[21]  Kallol Ray Chaudhuri,et al.  Parkinson's disease severity levels and MDS-Unified Parkinson's Disease Rating Scale. , 2015, Parkinsonism & related disorders.

[22]  Lynn Rochester,et al.  Progression of gait dysfunction in incident Parkinson's disease: Impact of medication and phenotype , 2015, Movement disorders : official journal of the Movement Disorder Society.