Gd‐Hybridized Plasmonic Au‐Nanocomposites Enhanced Tumor‐Interior Drug Permeability in Multimodal Imaging‐Guided Therapy

An original gadolinium-hybridized plasmonic gold nanocomposite is fabricated to provide an insightful and attractive strategy to overcome both the physiological and pathological barriers of tumor, and increase the transportation and permeability of imaging agents and drugs in tumor interior for achieving high-sensitive multimodal imaging and simultaneously improving the therapeutic efficacy of cancer.

[1]  Taeghwan Hyeon,et al.  Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. , 2009, Chemical Society reviews.

[2]  F. Cordelières,et al.  A guided tour into subcellular colocalization analysis in light microscopy , 2006, Journal of microscopy.

[3]  Ran Wei,et al.  Use of smart designed nanoparticles to impact cancer surgery , 2015 .

[4]  Gang Liu,et al.  Imaging-guided delivery of RNAi for anticancer treatment. , 2016, Advanced drug delivery reviews.

[5]  O. Tillement,et al.  Gadolinium-based nanoparticles for theranostic MRI-radiosensitization. , 2015, Nanomedicine.

[6]  Maurizio Fermeglia,et al.  Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance , 2015, Proceedings of the National Academy of Sciences.

[7]  H. W. Chalkley,et al.  Vasculae Reactions of Normal and Malignant Tissues in Vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic Transplants , 1945 .

[8]  A. S. Sobolev,et al.  Current Approaches for Improving Intratumoral Accumulation and Distribution of Nanomedicines , 2015, Theranostics.

[9]  M. Rabiet,et al.  Transmetallation of Gd-DTPA by Fe3+, Cu2+ and Zn2+ in water: batch experiments and coagulation-flocculation simulations. , 2014, Chemosphere.

[10]  Chunying Chen,et al.  Near‐Infrared Light‐Mediated Nanoplatforms for Cancer Thermo‐Chemotherapy and Optical Imaging , 2013, Advanced materials.

[11]  C. Brennan,et al.  A Brain Tumor Molecular Imaging Strategy Using A New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle , 2011, Nature Medicine.

[12]  Veit Rohde,et al.  Multiphoton excitation fluorescence microscopy of 5‐aminolevulinic acid induced fluorescence in experimental gliomas , 2008, Lasers in surgery and medicine.

[13]  Zhen Gu,et al.  Gel–Liposome‐Mediated Co‐Delivery of Anticancer Membrane‐Associated Proteins and Small‐Molecule Drugs for Enhanced Therapeutic Efficacy , 2014 .

[14]  Deirdre B. Cassidy,et al.  Revisiting the risks of MRI with Gadolinium based contrast agents—review of literature and guidelines , 2015, Insights into Imaging.

[15]  Yuanyi Zheng,et al.  A Versatile Nanotheranostic Agent for Efficient Dual‐Mode Imaging Guided Synergistic Chemo‐Thermal Tumor Therapy , 2015 .

[16]  Feng Gao,et al.  In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages. , 2010, ACS nano.

[17]  Z. Chai,et al.  Advanced nuclear analytical and related techniques for the growing challenges in nanotoxicology. , 2013, Chemical Society reviews.

[18]  C Zimmer,et al.  Pharmacokinetic analysis of glioma compartments with dynamic Gd-DTPA-enhanced magnetic resonance imaging. , 2000, Magnetic resonance imaging.

[19]  Paolo Decuzzi,et al.  Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy. , 2014, Small.

[20]  P. Singal,et al.  Doxorubicin-induced cardiomyopathy. , 1998, The New England journal of medicine.

[21]  Wanwan Li,et al.  Gold nanoparticles for photoacoustic imaging. , 2015, Nanomedicine.

[22]  Lothar Lilge,et al.  The Distribution of the Anticancer Drug Doxorubicin in Relation to Blood Vessels in Solid Tumors , 2005, Clinical Cancer Research.

[23]  M. Ferrari,et al.  Mild Hyperthermia Enhances Transport of Liposomal Gemcitabine and Improves In Vivo Therapeutic Response , 2015, Advanced healthcare materials.

[24]  B. Angelsen,et al.  Ultrasound-enhanced drug delivery in prostate cancer xenografts by nanoparticles stabilizing microbubbles. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[25]  Huang-Hao Yang,et al.  Co9Se8 Nanoplates as a New Theranostic Platform for Photoacoustic/Magnetic Resonance Dual‐Modal‐Imaging‐Guided Chemo‐Photothermal Combination Therapy , 2015, Advanced materials.

[26]  Taeghwan Hyeon,et al.  Nano‐Sized CT Contrast Agents , 2013, Advanced materials.

[27]  Jing Wang,et al.  Gold Nanorods Based Platforms for Light-Mediated Theranostics , 2013, Theranostics.

[28]  Kenneth W Dunn,et al.  A practical guide to evaluating colocalization in biological microscopy. , 2011, American journal of physiology. Cell physiology.

[29]  Yuliang Zhao,et al.  Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods. , 2014, Journal of the American Chemical Society.

[30]  Hua Ai,et al.  Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. , 2011, Accounts of chemical research.

[31]  M. Knauth,et al.  Low-field interventional MRI in neurosurgery: finding the right dose of contrast medium , 2001, Neuroradiology.

[32]  W. Tan,et al.  Fabrication of superstable gold nanorod–carbon nanocapsule as a molecule loading material , 2015 .

[33]  Dong Zhang,et al.  Colloids containing gadolinium-capped gold nanoparticles as high relaxivity dual-modality contrast agents for CT and MRI. , 2014, Colloids and surfaces. B, Biointerfaces.

[34]  Adam de la Zerda,et al.  A Comparison Between Time Domain and Spectral Imaging Systems for Imaging Quantum Dots in Small Living Animals , 2010, Molecular Imaging and Biology.

[35]  Yuliang Zhao,et al.  Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor , 2016 .

[36]  Hamidreza Ghandehari,et al.  Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors. , 2014, Nuclear medicine and biology.

[37]  P. Carmeliet,et al.  Heterogeneous vascular dependence of tumor cell populations. , 2001, The American journal of pathology.

[38]  Sangjin Park,et al.  Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. , 2007 .

[39]  Feng Zhao,et al.  Cancer therapy may get a boost from gold nanorods , 2015 .

[40]  Napoleone Ferrara,et al.  Angiogenesis as a therapeutic target , 2005, Nature.

[41]  Pengfei Wang,et al.  Gold nanorod@silica-carbon dots as multifunctional phototheranostics for fluorescence and photoacoustic imaging-guided synergistic photodynamic/photothermal therapy. , 2016, Nanoscale.

[42]  Mauro Ferrari,et al.  Tumor vascular permeabilization using localized mild hyperthermia to improve macromolecule transport. , 2014, Nanomedicine : nanotechnology, biology, and medicine.

[43]  Jing Wang,et al.  Mesoporous Silica‐Coated Gold Nanorods as a Light‐Mediated Multifunctional Theranostic Platform for Cancer Treatment , 2012, Advanced materials.

[44]  J. Willmann,et al.  Molecular ultrasound assessment of tumor angiogenesis , 2010, Angiogenesis.

[45]  Mauro Ferrari,et al.  Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast , 2010, Nature nanotechnology.